Modulation of Carbon Nanotubes' Perturbation to the Metabolic Activity of CYP3A4 in the Liver

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Modulation of Carbon Nanotubes' Perturbation to the Metabolic Activity of CYP3A4 in the Liver
	Zhang, Yi; Wang, Yabin; Liu, Aijuan; Xu, Sherry Li; Zhao, Bin; Zhang, Yi; Zou, Hanfa; Wang, Wenyi; Zhu, Hao; Yan, Bing
刊名	ADVANCED FUNCTIONAL MATERIALS
	2016-02-09
卷号	26 期号:6 页码:841-850
关键词	combinatorial chemistry CYP450 functionalized MWCNTs human liver microsome pharmacophores
英文摘要	The liver plays an important role in metabolizing foreign materials, such as drugs. The high accumulation of carbon nanotubes and other hydrophobic nanoparticles in the liver has raised concerns that nanoparticles may interfere with liver metabolic function. We report here that carbon nanotubes enter hepatic cells after intravenous introduction and interact with CYP enzymes, including CYP3A4. Surface chemical modifications alter the carbon nanotubes' interactions with CYP450 enzymes in human liver microsomes. They enhance, inhibit, or have no effect on the enzymatic function of CYP3A4. Using a cheminformatics analysis, certain chemical structures are identified on the surface of the carbon nanotubes that induce an enzyme inhibitory effect or prevent disruption of CYP3A4 enzymes.
收录类别	SCI
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/35897]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Zhang, Yi,Wang, Yabin,Liu, Aijuan,et al. Modulation of Carbon Nanotubes' Perturbation to the Metabolic Activity of CYP3A4 in the Liver[J]. ADVANCED FUNCTIONAL MATERIALS,2016,26(6):841-850.
APA	Zhang, Yi.,Wang, Yabin.,Liu, Aijuan.,Xu, Sherry Li.,Zhao, Bin.,...&Yan, Bing.(2016).Modulation of Carbon Nanotubes' Perturbation to the Metabolic Activity of CYP3A4 in the Liver.ADVANCED FUNCTIONAL MATERIALS,26(6),841-850.
MLA	Zhang, Yi,et al."Modulation of Carbon Nanotubes' Perturbation to the Metabolic Activity of CYP3A4 in the Liver".ADVANCED FUNCTIONAL MATERIALS 26.6(2016):841-850.