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科研机构
中南大学 [4]
南华大学 [3]
华中师范大学 [2]
复旦大学上海医学院 [2]
上海药物研究所 [1]
武汉轻工大学 [1]
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期刊论文 [14]
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W2476 represses TXNIP transcription via dephosphorylation of FOXO1 at Ser319
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2021, 页码: 11
作者:
Zhong, Li
;
Liu, Qing
;
Liu, Qiaofeng
;
Zhang, Shikai
;
Cao, Yongbing
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2021/05/24
chromatin immunoprecipitation
diabetes
transcription
TXNIP
W2476
Forkhead box D1 promotes proliferation and suppresses apoptosis via regulating polo-like kinase 2 in colorectal cancer
期刊论文
BIOMEDICINE & PHARMACOTHERAPY, 2018, 卷号: 103
作者:
Han, Tao
;
Lin, Jie
;
Wang, Yannan
;
Fan, Qihao
;
Sun, Haojie
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/12/05
Dietary supplementation of A-type procyanidins from litchi pericarp improves glucose homeostasis by modulating mTOR signaling and oxidative stress in diabetic ICR mice
期刊论文
Journal of Functional Foods, 2018, 卷号: 44, 页码: 155-165
作者:
Li, Xiaopeng
;
Wu, Qian
;
Sui, Yong
;
Li, Shuyi
;
Xie, Bijun
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2019/12/27
A-type procyanidins
Oxidative stress
Glucose homeostasis
Type 2 diabetes
mTOR
ACC1
acetyl coenzyme A carboxylase 1
ACL
ATP-citrate lyase
ALT
alanine aminotransferase
AST
aspartate aminotransferase
AUC
area under curve
BAT
brown adipose tissue
FAS
fatty acid synthase
FFA
free fatty acid
FoxO3a
Forkhead box O3a
FoxO1a
Forkhead box O3a
PKCβ
protein kinase C β
mTOR
mechanistic target of rapamycin
HDL
high-density lipoprotein
GHbA1c
glycated hemoglobin A1c
GK
glucokinase
G-6-Pase
glucose-6-phosphatase
GLP-1
glucagon-like peptide-1
GSH-PX
total glutathione peroxidase
HOMA-IR
homeostatic model assessment of insulin resistance
LDHA
lactate dehydrogenase
LDL
low-density lipoprotein
LPOPC
oligomeric procyanidins of litchi pericarp
MDA
malondialdehyde
MnSOD
manganese superoxide dismutase
mTOR
mechanistic target of rapamycin
OGTT
oral glucose tolerance test
PDH
pyruvate dehydrogenase
PEPCK
phosphoenolpyruvate carboxykinase
PFK
phosphofructokinase
PK
pyruvate kinase
PKCβ
protein kinase C β
PPG
postprandial blood glucose
S6K1
S6 Kinase 1
PKCβ
protein kinase C β
RTK
receptor tyrosine kinase
SREBP-1c
sterol regulatory element-binding protein 1c
ACL
ATP-citrate lyase
ACC1
acetyl coenzyme A carboxylase 1
FAS
fatty acid synthase
SCD1
stearoyl CoA desaturase 1
STZ
streptozotocin
S6K1
S6 kinase 1
PPG
postprandial blood glucose
ROS
reactive oxygen species
TC
total cholesterol
TG
triacylglycerol
STZ
streptozotocin
T-AOC
total antioxidant capacity
T-SOD
total superoxide dismutase
UCP-1
uncoupling protein 1
WAT
white adipose tissue
XOS
xylo-oligosaccharides
Metformin, beyond an insulin sensitizer, targeting heart and pancreatic β cells
期刊论文
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2017, 卷号: 1863, 期号: 8, 页码: 1984-1990
作者:
Yang, Xin
;
Xu, Zhipeng
;
Zhang, Chunlan
;
Cai, Zixin
;
Zhang, Jingjing*
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2019/12/03
A1c
glycated hemoglobin
AACE
American Association of Clinical Endocrinologists
ACC
acetyl-CoA carboxylase
ADA
American Diabetes Association
Akt/PKB
tyrosine kinase/protein kinase B
AMP
adenosine monophosphate
AMPK
adenosine monophosphate-activated protein
Ang II
angiotensin II
ATP
adenosine triphosphate
BAT
brown adipose tissue
CHOP
CEBP-homologous protein
CEBP
CCAAT enhancer binding protein
CoA
coenzyme A
DPP
Diabetes Prevention Program
EASD
European Association for the Study of Diabetes
eNOS
endothelial nitric oxide synthase
ER
endoplasmic reticulum
FDA
Food and Drug Administration
FFA
free fatty acid
FOXO1
forkhead box protein O1
G6P
glucose 6-phosphate
GDM
gestational diabetes mellitus
GIPR
glucose-dependent insulinotropic polypeptide receptor
GLP-1R
glucagon-like peptide-1 receptor
GLUT1
glucose transporter-1
GLUT4
glucose transporter type 4
GLUTs
glucose transporters
G6P
glucose 6-phosphate, glucose transporter-1
GPR40
G protein-coupled receptor 40
HbA1c
hemoglobin A1c
HGP
hepatic glucose production
HSL
hormone sensitive lipase
IL-6
interleukin 6
INS-1
insulinoma cells in rat
IR
insulin resistance
IRS-1
insulin receptor substrate 1
JNK
c-Jun. N-terminal kinase
Kir6.2
inwardly rectifying potassium/kalium channel
LDs
lipid droplets
LDL
low density lipoprotein
LV
left ventricular
MIN6 cells
mouse insulinoma cells
MAPK
mitogen-activated protein kinases
mPTP
mitochondrial permeability transition pore opening
mTOR
mammalian target of rapamycin
NADPH
nicotinamide adenine dinucleotide phosphate
NF-kappaB
nuclear factors-kappa B
NIT-1 cells
insulinoma cells
p70S6K
p70 ribosomal S6 kinase
PA
palmitic acid
NOS
NADPH oxidase
p38 MAPK
p38 mitogen-activated protein kinase
PA
palmitic acid
PCOS
polycystic ovary syndrome
PGC-1α
peroxisome proliferator-activated receptor-g coactivator-1α
PI3K
phosphatidylinositol 3-kinase
PKB
protein kinase B
PKC
protein kinase C
PPARα
peroxisome-proliferator activated receptor α
PTP
permeability transition pore
RCT
randomized controlled trial
RISK
reperfusion injury salvage kinase
ROS
reactive oxygen species
SERCA2
reticulum sarcoplasmic Ca2 +-ATPase
RISK
reperfusion injury salvage kinase
Smad3
mothers against decapentaplegic homolog 3
SRC-2
steroid receptor coactivator 2
T1DM
Type 1 diabetes mellitus
T2DM
Type 2 diabetes mellitus
TGFβ1
transforming growth factor β1
TLR4
Toll-like receptor
TNF-α
tumor necrosis factor α
TR4
testicular receptor 4
UKPDS
United Kingdom Prospective Diabetes Study
VLDL
very low density lipoprotein
Metformin
Pancreatic β Cells
Heart failure
Insulin sensitizer
The role of miRNA-223 in cancer: Function, diagnosis and therapy
期刊论文
Gene, 2017, 卷号: 616, 页码: 1-7
作者:
Gao, Yunliang
;
Lin, Le
;
Li, Tao
;
Yang, Jinrui*
;
Wei, Yongbao*
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/12/03
miRNAs
MicroRNAs
UTR
The 3′ untranslated region
oncomiRs
Oncogenic miRNAs
miR-223
miRNA-223
T-ALL
T-cell acute lymphoblastic leukemia
AML
Acute myeloid leukemia
NSCLC
Nonsmall cell lung cancer
C/EBP
CCAAT-enhancer-binding protein
NFI-A
Nuclear factor I-A
HSP90B1
Heat Shock Protein 90 kDa Beta Family Member 1
IGF-1R
Insulin-like growth factor-1 receptor
FOXO1
Transcription factor Forkhead box O1
NPC
Nasopharyngeal carcinoma
EMT
Epithelial-to-mesenchymal transformation
Mef2c
Myocyte enhancer factor 2c
EBV
Epstein–Barr virus
JMML
Juvenile myelomonocytic leukemia
EPB41L3
Erythrocyte membrane protein band 4.1-like 3
HCC
Hepatocellular carcinoma
miR-223
Cancer
Biological function
Oncogene
Tumor promoter
Biomarker
Oncotherapy
Myocardin: A novel player in atherosclerosis
期刊论文
Atherosclerosis, 2017, 卷号: 257, 页码: 266-278
作者:
Xia, Xiao-Dan
;
Zhou, Zhen
;
Yu, Xiao-Hua
;
Zheng, Xi-Long
;
Tang, Chao-Ke*
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2019/12/27
Myocardin
Atherosclerosis
Inflammation
Lipid metabolism
VSMC
Abca1
MYOCD
Myocardin
AS
atherosclerosis
SRF
serum response factor
VSMC
vascular smooth muscle cell
Mrtf-A/B
Myocardin-related transcription factors A/B
Mamstr
Mef2-activating SAP transcriptional protein
SAP domain
scaffold attachment factors A and B (SAF-A and -B), Acinus, and PIAS
MADS
MCM1, Agamous, Deficiens, SRF-box transcription factor
TAD
transactivation domain
NTD
N-terminal domain
Arp5
actin-related protein 5
Tead
TEA domain transcription factor
Foxo
forkhead transcription factor
Cdc7
cell division cycle 7
Mef2
myocyte-specific enhancer factor
Nfatc3
nuclear factor of activated T cells c3
hnRNPA1
heterogeneous nuclear ribonucleoprotein A1
Tet2
ten-eleven translocation-2
TGF-β
transforming growth factor-β
URR
upstream repressor region
Klf4
Kruppel-like factor4
PRR
platelet-derived growth factor-BB-responsive region
Pkcα
protein kinase C α
MSCs
mesenchymal stem cells
lncRNAs
long non-coding RNAs
MicroRNAs
small non-encoding RNAs
UTR
un-translated region
Abca1
ATP-binding cassette transporter A1
RCT
reverse cholesterol transport
Bridges between mitochondrial oxidative stress, ER stress and mTOR signaling in pancreatic β cells
期刊论文
Cellular Signalling, 2016, 卷号: 28, 期号: 8, 页码: 1099-1104
作者:
Wang, Jing
;
Yang, Xin
;
Zhang, Jingjing*
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/12/03
4E-BP1
4E binding protein
AMPK
AMP-activated protein kinase
ATF6
activating transcription factor 6
ATP
adenosine triphosphate
DEPTOR
DEP domain containing mTOR-interacting protein
CI
complexes I
CII
complex II
CIII
complex III
CIV
complex IV
CV
complex V
eIF2α
Eukaryotic Initiation Factor 2α
ER
Endoplasmic Reticulum
ERAD
ER-associated degradation
ERO1α
ER oxidoreductase 1 α
FoxO1
Forkhead box O1
GβL
G Protein β Subunit Like Protein
GRP78
78 kDa glucose-regulated protein precursor
GSIS
glucose-stimulated insulin secretion
IRE1
Inositol-requiring enzyme 1
IRS1
Insulin receptor substrate 1
IRS2
Insulin receptor substrate 2
mLST8
mammalian lethal with sec-13 protein 8
mSin1
the mammalian stress-activated MAP kinase-interaction protein 1
mtDNA
mitochondrial deoxyribonucleic acid
mTOR
mammalian TOR
mTORC1
mTOR complex 1
mTORC2
mTOR complex 2
NADPH oxidase
Nicotinamide adenine dinucleotide phosphate-oxidase
NOS
nitric oxide synthase
O2–·
superoxide anion
H2O2
hydrogen peroxide
OH·
hydroxyl radical
3O2
triplet-state molecular oxygen
OXPHOS
oxidative phosphorylation
CAT
catalase
GPx
glutathioneperoxidase
PERK
Protein kinase R-like endoplasmic reticulum kinase
PDI
ER protein disulfide isomerases
PI3K
the phosphoinositide3-kinase
PRAS40
40-kDa proline-rich Akt substrate
PRAS40
the 40-kDa proline-rich Akt substrate
PROTOR
the protein observed with RICTOR
RAPTOR
regulatory-associated protein of mTOR
RICTOR
The rapamycin-insensitive companion of mTOR
REDD1
DNA damage response 1
RNS
reactive nitrogen species
ROS
reactive oxygen species
RNS
reactive nitrogen species
S6K
S6 kinase
SOD
superoxidedismutase
T1DM
Type 1 diabetes mellitus
T2DM
Type 2 diabetes mellitus
TOR
the target of rapamycin
TSC2
Tuberous sclerosis 2
UPR
unfolded protein response
Mitochondrial oxidative stress
ER stress
mTOR
Pancreatic β cells
Epigenetic mechanisms: An emerging role in pathogenesis and its therapeutic potential in systemic sclerosis
期刊论文
The International Journal of Biochemistry & Cell Biology, 2015, 卷号: 67, 页码: 92-100
作者:
Luo, Yangyang
;
Wang, Yong
;
Shu, Ye
;
Lu, Qianjin
;
Xiao, Rong*
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/12/03
SSc
systemic sclerosis
SRC
scleroderma renal crisis
PAH
pulmonary arterial hypertension
SMR
standardized mortality ratio
DNMTs
DNA methyltransferases
SAM
S-adenosyl-methionine
5mC
5-methylcytosine
MBD
methyl-CpG-binding domain
Tet
ten–eleven translocation
HATs
histone acetyltransferases
HDACs
histone deacetylases
MiRNAs
microRNAs
MZ
monozygotic
DZ
dizygotic
MVECs
microvascular endothelial cells
FBs
fibroblasts
JAMs
junctional adhesion molecules
CTGF
connective tissue growth facto
TGF-β
transforming growth factor beta
CCN2
connective tissue growth factor
Fli1
Friend leukemia integration-1
TF
transcription factor
PECAM
platelet/endothelial cell adhesion molecule
PDGF
platelet derived growth factor
S1P1
sphingosin 1 phosphate
CXCL5
CXC chemokine ligand-5
BMPs
bone morphogenetic proteins
BMPRII
bone morphogenetic protein type II receptor
ET-1
endotheline-1
uPA
urokinase-type plasminogen activator
MBD
methyl-CpG-binding domain protein
ICAM
intercellular adhesion molecule
KLF5
Kruppel-like factor 5
Tregs
regulatory T cells
Runx1
Runt-related transcription factor 1
FOXP3
forkhead box protein 3 gene
ECM
extra cellular matrix
PDGF
platelet-derived growth factor
dSSc
diffuse systemic sclerosis
lSSc
limited systemic sclerosis
PCAF
protein-associated factor
Egr-1
early growth response 1
DDR2
discoidin domain receptor 2
TAB1
TGF-β activated kinase 1 binding protein 1
BAFF
B cell-activating factor
TSP-2
thrombospondin-2
MRTSS
Modified Rodnan total skin score
SDAI
Valentini scleroderma disease activity index
HC
healthy controls
SLE
systemic lupus erythematosus
SSD
scleroderma spectrum disorder
MTX
methylaminopterin
CYC
cyclophosphamide
MMF
mycophenolate mofetil
ACE
angiotensin converting enzyme
NO
nitric oxide
Systemic sclerosis
Epigenetic mechanisms
Biomarker
Therapy
Mammalian Sterile 20-like Kinase 1 (Mst1) Enhances the Stability of Forkhead Box P3 (Foxp3) and the Function of Regulatory T Cells by Modulating Foxp3 Acetylation
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 卷号: 290, 期号: 52
作者:
Li, Jiang
;
Du, Xingrong
;
Shi, Hao
;
Deng, Kejing
;
Chi, Hongbo
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/19
Apolipoprotein M
期刊论文
Clinica chimica acta, international journal of clinical chemistry, 2015, 卷号: 446, 页码: 21-29
作者:
Ren, Kun
;
Tang, Zhen-Li
;
Jiang, Yue
;
Tan, Yan-Mei
;
Yi, Guang-Hui*
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/12/27
apo
apolipoprotein
HDL
high-density lipoprotein
HNF-1α,4α
hepatocyte nuclear factor-1α,4α
LRH-1
liver receptor homolog-1
Foxa2
forkhead box A2
PAF
platelet activating factor
LXR
liver X receptor
RXR
retinoid X receptor
FXR
farnesoid X receptor
SHP
small heterodimer partner
S1P
Sphingosine-1-Phosphate
CVD
cardiovascular disease
HDL-C
HDL cholesterol
RCT
reverse cholesterol transport
MHC
major histocompatibility complex class III
TNF
tumor necrosis factor
HRP
haptoglobin-related protein
PON-I
paraoxonase-1
SNP
single nucleotide polymorphism
T1,2D
type 1,2 diabetes
RA
rheumatoid arthritis
ABCA1
ATP-binding cassette transporter A1
PPAR-γ
peroxisome proliferator-activated receptor γ
IL
interleukin
ABCG
ATP-binding cassette sub-family G
CETP
cholesteryl ester transfer protein
SR-B1
scavenger receptor class B member 1
MODY3
maturity-onset diabetes of the young type 3
MUP
major urinary protein
RBP
retinol binding protein
RAR
retinoic acid receptor
TR
thyroid hormone receptor
PI3K
phosphatidylinositol 3-kinase
DHC
dihydrocapsaicin
HRE
hormone response element
IGF-1
insulin-like growth factors
PAF-R
platelet activating factor receptor
TGF-α,β
transforming growth factor-α,β
EGF
epidermal growth factor
HGF
hepatic growth factor
VLDL
very low-density lipoprotein
LDL
low-density lipoprotein
ldlr
LDL receptor
ldlr−/−
LDL-receptor deficient
LCAT
lecithin-cholesterol acyltransferase
CE
cholesteryl ester
TC
total cholesterol
LDL-C
LDL cholesterol
VLDL-C
VLDL cholesterol
CHD
coronary heart disease
Mets
metabolic syndrome
S1PR
S1P receptor
NF-κB
nuclear factor-κB
NO
nitrogen oxide
eNOS
endothelial nitric oxide synthase
apoM-TgN mice
mice overexpressing human apoM by approximately two-fold
apoM-TgH mice
mice overexpressing human apoM by approximately ten-fold
apoM−/− mice
apoM-null mice
apoE−/−
apoE-null mice
Apolipoprotein M
Regulation
Function
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