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Signaling profiles in HEK 293T cells co-expressing GLP-1 and GIP receptors
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 8
作者:
Wang, Yu-zhe
;
Yang, De-hua
;
Wang, Ming-wei
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/11/04
glucagon-like peptide-1 receptor
glucose-dependent insulinotropic peptide receptor
peptide 19
LY3298176
heteromerization
type 2 diabetes
Design, synthesis and pharmacological evaluation of tricyclic derivatives as selective RXFP4 agonists
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 110, 页码: 17
作者:
Lin, Lin
;
Lin, Guangyao
;
Zhou, Qingtong
;
Bathgate, Ross A. D.
;
Gong, Grace Qun
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2021/08/17
Synthesis
Structure-activity relationship
Relaxin family peptide receptor 4
Selective agonist
Molecular docking
Evaluation of biased agonism mediated by dual agonists of the GLP-1 and glucagon receptors
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2020, 卷号: 180, 页码: 16
作者:
Darbalaei, Sanaz
;
Yuliantie, Elita
;
Dai, Antao
;
Chang, Rulue
;
Zhao, Peishen
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2020/12/21
G protein-coupled receptor
Glucagon-like peptide-1 receptor
Glucagon receptor
Biased agonism
Unimolecular dual agonist
Cryo-electron microscopy structure of the glucagon receptor with a dual-agonist peptide
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 卷号: 295, 期号: 28, 页码: 9313-9325
作者:
Chang, Rulue
;
Zhang, Xin
;
Qiao, Anna
;
Dai, Antao
;
Belousoff, Matthew J.
收藏
  |  
浏览/下载:85/0
  |  
提交时间:2020/12/24
glucagon receptor
glucagon-like peptide-1 receptor
dual agonist
cryo-electron microscopy
single particle analysis
structure-function
structural biology
peptide 15 (P15)
metabolic disorder
G protein?coupled receptor (GPCR)
glucagon
GLP-1 receptor
Pharmacological characterization of mono-, dual- and tri-peptidic agonists at GIP and GLP-1 receptors
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2020, 卷号: 177, 页码: 13
作者:
Yuliantie, Elita
;
Darbalaei, Sanaz
;
Dai, Antao
;
Zhao, Peishen
;
Yang, Dehua
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2020/12/24
G protein-coupled receptor
Glucose-dependent insulinotropic peptide receptor
Glucagon-like peptide-1 receptor
Biased agonist
GPCR signaling
Recent advances in dopaminergic strategies for the treatment of Parkinson's disease
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 12
作者:
Mao, Qi
;
Qin, Wang-zhi
;
Zhang, Ao
;
Ye, Na
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2020/07/01
Parkinson's disease
dopamine
D-1 receptor
D-2 receptor
allosteric modulator
neuroprotection
multitarget
drug discovery and development
neurodegenerative diseases
Discovery of betulinaldehyde as a natural ROR gamma t agonist
期刊论文
FITOTERAPIA, 2019, 卷号: 137, 页码: 8
作者:
Yang, Feng
;
Zhang, Ruihan
;
Ni, Dongxuan
;
Luo, Xiaomin
;
Chen, Shijie
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2020/07/01
ROR gamma t
Receptor agonist
Triterpenoids
Alpha screen
Molecular docking
Structure of the glucagon receptor in complex with a glucagon analogue
期刊论文
NATURE, 2018, 卷号: 553, 期号: 7686, 页码: 106-+
作者:
Zhang, Haonan
;
Qiao, Anna
;
Yang, Linlin
;
Van Eps, Ned
;
Frederiksen, Klaus S.
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2019/01/08
Cefminox, a Dual Agonist of Prostacyclin Receptor and Peroxisome Proliferator-Activated Receptor-Gamma Identified by Virtual Screening, Has Therapeutic Efficacy against Hypoxia-Induced Pulmonary Hypertension in Rats
期刊论文
FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9
作者:
Xia, Jingwen
;
Yang, Li
;
Dong, Liang
;
Niu, Mengjie
;
Zhang, Shengli
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/12/05
hypoxia-induced pulmonary hypertension
prostacyclin receptor
peroxisome proliferator-activated receptor-gamma
phosphatase and tensin homolog
cyclic adenosine monophosphate
Cefminox, a Dual Agonist of Prostacyclin Receptor and Peroxisome Proliferator-Activated Receptor-Gamma Identified by Virtual Screening, Has Therapeutic Efficacy against Hypoxia-Induced Pulmonary Hypertension in Rats
期刊论文
FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9
作者:
Xia, Jingwen
;
Yang, Li
;
Dong, Liang
;
Niu, Mengjie
;
Zhang, Shengli
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/11/26
prostacyclin receptor
phosphatase and tensin homolog
cyclic adenosine monophosphate
peroxisome proliferator-activated receptor-gamma
hypoxia-induced pulmonary hypertension
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