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Visualization of Alzheimer's Disease Related alpha-/beta-/gamma-Secretase Ternary Complex by Bimolecular Fluorescence Complementation Based Fluorescence Resonance Energy Transfer
期刊论文
FRONTIERS IN MOLECULAR NEUROSCIENCE, 2018, 卷号: 11, 期号: 1, 页码: 431
作者:
Wang, Xin
;
Pei, Gang
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/04/28
Amyloid Precursor Protein
Beta-secretase
App
Site
Cleavage
Adam10
Bace1
Localization
Dimerization
Endocytosis
Amyloid beta: structure, biology and structure-based therapeutic development
期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 9, 页码: 1205-1235
作者:
Chen, Guo-fang
;
Xu, Ting-hai
;
Yan, Yan
;
Zhou, Yu-ren
;
Jiang, Yi
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2019/01/08
amyloid beta peptide
amyloid precursor protein
Alzheimer's disease
neurodegenerative diseases
drug discovery
amyloidbetastructurebiologyandstructurebasedtherapeuticdevelopment
期刊论文
actapharmacologicasinica, 2017, 卷号: 38, 期号: 9, 页码: 1205
作者:
Chen Guofang
;
Xu Tinghai
;
Yan Yan
;
Zhou Yuren
;
Jiang Yi
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2020/07/01
BLOOD-BRAIN-BARRIER
INSULIN-DEGRADING ENZYME
SOLID-STATE NMR
NICOTINIC ACETYLCHOLINE-RECEPTORS
METABOTROPIC GLUTAMATE RECEPTORS
ATOMIC-FORCE MICROSCOPY
GAMMA-SECRETASE COMPLEX
SMOOTH-MUSCLE-CELLS
AMELIORATES MEMORY IMPAIRMENT
ENDOTHELIN-CONVERTING ENZYME
amyloid beta peptide
amyloid precursor protein
Alzheimer's disease
neurodegenerative diseases
drug discovery
Fluorescent turn-on determination of the activity of peptidases using peptide templated gold nanoclusters
期刊论文
Microchimica Acta, 2016, 卷号: 183, 期号: 2, 页码: 605-610
作者:
Luo, Junjun
;
Rasooly, Avraham
;
Wang, Liqiang
;
Zeng, Ke
;
Shen, Congcong
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/03
beta-Secretases
APP cleaving enzyme
BACE1
beta-amyloid precursor protein
Transmission electron microscopy
Fluorometry
Trafficking regulation of proteins in Alzheimer's disease
期刊论文
http://dx.doi.org/10.1186/1750-1326-9-6, 2014
Jiang, Shangtong
;
Li, Yanfang
;
Zhang, Xian
;
Bu, Guojun
;
Xu, Huaxi
;
Zhang, Yun-wu
;
卜国军
;
许华曦
;
张云武
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2015/07/22
AMYLOID PRECURSOR PROTEIN
TRANS-GOLGI NETWORK
GAMMA-SECRETASE ACTIVITY
SORTILIN-RELATED RECEPTOR
BETA PEPTIDE GENERATION
NECROSIS-FACTOR-ALPHA
INTRACELLULAR TRAFFICKING
ENDOPLASMIC-RETICULUM
APOLIPOPROTEIN-E
CLEAVING ENZYME
Increased expression of reticulon 3 in neurons leads to reduced axonal transport of beta site amyloid precursor protein-cleaving enzyme 1.
期刊论文
Journal of Biological Chemistry, 2013, 卷号: 288, 期号: 42, 页码: 30236-30245
作者:
Deng, Minzi
;
He, Wanxia
;
Tan, Ya
;
Han, Hailong
;
Hu, Xiangyou
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/12/03
Alzheimer Disease
Amyloid Precursor Protein
Axonal Transport
BACE1
Confocal Microscopy
Kymograph
RTN3
Secretases
Synapses
Synaptic Localization
An enzyme-linked immunosorbent assay to compare the affinity of chemical compounds for beta-amyloid peptide as a monomer
期刊论文
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2010, 卷号: 396, 期号: 5, 页码: 1745-1754
作者:
Jiang, Chunyi
;
Feng, Yu
;
Huang, Xiaotong
;
Xu, Yechun
;
Zhang, Yaping
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
Enzyme-linked immunosorbent assay
beta-Amyloid peptide
Binding affinity
Inhibitor
Bcl-x(L)
Regulation of beta cleavage of amyloid precursor protein
期刊论文
NEUROSCIENCE BULLETIN, 2010, 卷号: 26, 期号: 5, 页码: 417-427
Wang, Jun-Feng
;
Lu, Rui
;
Wang, Yi-Zheng
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2012/07/13
Alzheimer's disease
amyloid beta peptide
amyloid precursor protein
beta secretase
APP TRANSGENIC MICE
ALZHEIMERS-DISEASE
A-BETA
SECRETASE ACTIVITY
PLAQUE-FORMATION
GAMMA-SECRETASE
GENE-EXPRESSION
IN-VIVO
BACE1
BRAIN
A GPCR/secretase complex regulates beta- and gamma-secretase specificity for A beta production and contributes to AD pathogenesis
期刊论文
CELL RESEARCH, 2010, 卷号: 20, 期号: 2, 页码: 138-153
作者:
Teng, L
;
Zhao, J
;
Wang, FF
;
Ma, L
;
Pei, G
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2015/07/22
G protein-coupled receptor
Alzheimer's disease
BACE
gamma-secretase
Notch
Intracellular Trafficking of Presenilin 1 Is Regulated by beta-Amyloid Precursor Protein and Phospholipase D1
期刊论文
http://dx.doi.org/10.1074/jbc.M808497200, 2009
Liu, Yun
;
Zhang, Yun-wu
;
Wang, Xin
;
Zhang, Han
;
You, Xiaoqing
;
Liao, Francesca-Fang
;
Xu, Huaxi
;
章慧
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2013/12/12
FAMILIAL ALZHEIMERS-DISEASE
TRANS-GOLGI NETWORK
GAMMA-SECRETASE COMPLEX
AXONAL-TRANSPORT
ANTEROGRADE TRANSPORT
CELLULAR MECHANISMS
MAMMALIAN-CELLS
CLEAVING ENZYME
DISTINCT SITES
APP
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