Regulation of beta cleavage of amyloid precursor protein

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	Regulation of beta cleavage of amyloid precursor protein
	Wang, Jun-Feng ; Lu, Rui ; Wang, Yi-Zheng
刊名	NEUROSCIENCE BULLETIN
	2010
卷号	26 期号:5 页码:417-427
关键词	Alzheimer's disease amyloid beta peptide amyloid precursor protein beta secretase APP TRANSGENIC MICE ALZHEIMERS-DISEASE A-BETA SECRETASE ACTIVITY PLAQUE-FORMATION GAMMA-SECRETASE GENE-EXPRESSION IN-VIVO BACE1 BRAIN
ISSN号	1673-7067
通讯作者	Wang, YZ (reprint author), Shanghai Inst Biol Sci, Inst Neurosci, Lab Neural Signal Transduct, State Key Lab Neurosci, Shanghai 200031, Peoples R China,yzwang@ion.ac.cn
英文摘要	Alzheimer's disease ranks the first cause for senile dementia. The amyloid cascade is proposed to contribute to the pathogenesis of this disease. In this cascade, amyloid beta peptide (A beta) is produced through a sequential cleavage of amyloid precursor protein (APP) by beta and gamma secretases, while its cleavage by alpha secretase precludes A beta production and generates neurotrophic sAPP alpha. Thus, enhancing alpha secretase activity or suppressing beta and gamma cleavage may reduce A beta formation and ameliorate the pathological process of the disease. Several regulatory mechanisms of APP cleavage have been established. The present review mainly summarizes the signaling pathways pertinent to the regulation of APP beta cleavage.
学科主题	Neurosciences & Neurology
收录类别	SCI
资助信息	National Natural Science Foundation of China[30711120566]
语种	英语
公开日期	2012-07-13
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1573]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Wang, Jun-Feng,Lu, Rui,Wang, Yi-Zheng. Regulation of beta cleavage of amyloid precursor protein[J]. NEUROSCIENCE BULLETIN,2010,26(5):417-427.
APA	Wang, Jun-Feng,Lu, Rui,&Wang, Yi-Zheng.(2010).Regulation of beta cleavage of amyloid precursor protein.NEUROSCIENCE BULLETIN,26(5),417-427.
MLA	Wang, Jun-Feng,et al."Regulation of beta cleavage of amyloid precursor protein".NEUROSCIENCE BULLETIN 26.5(2010):417-427.