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科研机构
上海药物研究所 [4]
四川大学 [1]
内容类型
期刊论文 [5]
发表日期
2011 [1]
2010 [2]
2009 [2]
学科主题
Pharmacolo... [1]
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An Examination of the Potential Effect of Lipids on the First-Pass Metabolism of the Lipophilic Drug Anethol Trithione
期刊论文
JOURNAL OF PHARMACEUTICAL SCIENCES, 2011, 卷号: 100, 期号: 11, 页码: 5048-5058
作者:
Yu, Hong-Zhen
;
Han, Si-Fei
;
Li, Ping
;
Zhu, Chun-Liu
;
Zhang, Xin-Xin
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/01/08
anethol trithione
medium chain triglycerides
first-pass metabolism
hepatic metabolism
nonlinear pharmacokinetics
dose proportionality
drug metabolizing enzymes
inhibition
formulation
lipids
Design, Synthesis and Biological Evaluation of Lipophilic Analogs of Anethol Trithione
期刊论文
Letters in Drug Design & Discovery, 2010, 卷号: Vol.7 No.10, 页码: 747-753
作者:
Xiao-Cen Li
;
Wei Fan
;
Li Hai
;
Shan Qian
;
Qui-Qi Xiao and Mei Guan
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/03/26
Synthesis
Anethol
trithione
Lipophilicity
Bioavailability
Prodrugs
ATT
glutamyl
cysteine
synthetase
glutathione
GSH
IR
HNMR
ESI-MS
pyridine
hydrochloride
HPLC
alanine
transaminases
aspartate
transaminases
AST
Acute
Toxicity
Test
maximum
tolerated
dose
YRT-3
melting
point
apparatus
IR
spectra
Perkin-Elmer983
NMR
spectra
INOVA400
Bruker
AC-E200
Agilent
1946B
ESI-MS
instrument
5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione
4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl
acetate
4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl
propionate
(E)-4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl
but-2-enoate
4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl
isobutyrate
4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl
benzoate
4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl
2-phenylacetate
4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl
stearate
4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl
pivalate
4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl
cinnamate
4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl
2-fluorobenzoate
4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl
4-chlorobenzoate
4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl
3-phenylpropanoate
4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl
3,3-diphenylpropan-oate
(3-thioxo-3H-1,2-dithiol-5-yl)phenyl
1,2,3,4-tetrahydro-naphthalene-1-carboxylate
(3o)
4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl
5,6,7,8-tetrahydro-naphthalene-1-carboxylate
SPD-10A
variable
UV-VIS
detector
ODS
column
ICR
mice
Preparation of anethol trithione-phospholipid complex and studies on its pharmacokinetics in rats
期刊论文
Journal of Shenyang Pharmaceutical University, 2010, 卷号: 27, 期号: 3, 页码: 168-173
作者:
YAO Ting-ting
;
GAN Yong
;
HAN Si-fei
;
ZHU Chun-liu
;
HU Shen-ye
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  |  
浏览/下载:12/0
  |  
提交时间:2019/01/08
anethol trithione
phospholipid complex
pharmacokinetics
Lipid-based formulations to enhance oral bioavailability of the poorly water-soluble drug anethol trithione: Effects of lipid composition and formulation
期刊论文
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2009, 卷号: 379, 期号: 1, 页码: 18-24
作者:
Han, Si-fei
;
Yao, Ting-ting
;
Zhang, Xin-xin
;
Gan, Li
;
Zhu, Chunliu
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
Anethol trithione
Lipid formulation
Lipid digestion
Intestinal absorption
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