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上海药物研究所 [3]
高能物理研究所 [1]
海洋研究所 [1]
武汉植物园 [1]
中南大学 [1]
复旦大学上海医学院 [1]
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期刊论文 [9]
学位论文 [1]
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2020 [2]
2017 [3]
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2015 [2]
2014 [2]
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主要研究方向::海洋... [1]
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Discovery of novel CBP bromodomain inhibitors through TR-FRET-based high-throughput screening
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 卷号: 41, 期号: 2, 页码: 286-292
作者:
Zhang, Feng-cai
;
Sun, Zhong-ya
;
Liao, Li-ping
;
Zuo, Yu
;
Zhang, Dan
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2020/07/01
CBP bromodomain
small-molecule inhibitor
high-throughput screening
TR-FRET
molecular modeling
human leukemia MV4-11 cells
discoveryofnovelcbpbromodomaininhibitorsthroughtrfretbasedhighthroughputscreening
期刊论文
actapharmacologicasinica, 2020, 卷号: 41, 期号: 2, 页码: 285
作者:
Zhang Fengcai
;
Sun Zhongya
;
Liao Liping
;
Zuo Yu
;
Zhang Dan
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2020/07/01
CBP bromodomain
small-molecule inhibitor
high-throughput screening
TR-FRET
molecular modeling
human leukemia MV4-11 cells
Virus-inspired self-assembled nanofibers with aggregation-induced emission for highly efficient and visible gene delivery
期刊论文
Acs applied materials & interfaces, 2017, 卷号: 9, 期号: 5, 页码: 4425-4432
作者:
Zhang, Chunqiu
;
Zhan, Tingbin
;
Jin, Shubin
;
Xue, Xiangdong
;
Yang, Xiaolong
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2019/04/23
Gene delivery
Peptide
Nanofibers
Transfection
Self-indicating
Metformin, beyond an insulin sensitizer, targeting heart and pancreatic β cells
期刊论文
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2017, 卷号: 1863, 期号: 8, 页码: 1984-1990
作者:
Yang, Xin
;
Xu, Zhipeng
;
Zhang, Chunlan
;
Cai, Zixin
;
Zhang, Jingjing*
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2019/12/03
A1c
glycated hemoglobin
AACE
American Association of Clinical Endocrinologists
ACC
acetyl-CoA carboxylase
ADA
American Diabetes Association
Akt/PKB
tyrosine kinase/protein kinase B
AMP
adenosine monophosphate
AMPK
adenosine monophosphate-activated protein
Ang II
angiotensin II
ATP
adenosine triphosphate
BAT
brown adipose tissue
CHOP
CEBP-homologous protein
CEBP
CCAAT enhancer binding protein
CoA
coenzyme A
DPP
Diabetes Prevention Program
EASD
European Association for the Study of Diabetes
eNOS
endothelial nitric oxide synthase
ER
endoplasmic reticulum
FDA
Food and Drug Administration
FFA
free fatty acid
FOXO1
forkhead box protein O1
G6P
glucose 6-phosphate
GDM
gestational diabetes mellitus
GIPR
glucose-dependent insulinotropic polypeptide receptor
GLP-1R
glucagon-like peptide-1 receptor
GLUT1
glucose transporter-1
GLUT4
glucose transporter type 4
GLUTs
glucose transporters
G6P
glucose 6-phosphate, glucose transporter-1
GPR40
G protein-coupled receptor 40
HbA1c
hemoglobin A1c
HGP
hepatic glucose production
HSL
hormone sensitive lipase
IL-6
interleukin 6
INS-1
insulinoma cells in rat
IR
insulin resistance
IRS-1
insulin receptor substrate 1
JNK
c-Jun. N-terminal kinase
Kir6.2
inwardly rectifying potassium/kalium channel
LDs
lipid droplets
LDL
low density lipoprotein
LV
left ventricular
MIN6 cells
mouse insulinoma cells
MAPK
mitogen-activated protein kinases
mPTP
mitochondrial permeability transition pore opening
mTOR
mammalian target of rapamycin
NADPH
nicotinamide adenine dinucleotide phosphate
NF-kappaB
nuclear factors-kappa B
NIT-1 cells
insulinoma cells
p70S6K
p70 ribosomal S6 kinase
PA
palmitic acid
NOS
NADPH oxidase
p38 MAPK
p38 mitogen-activated protein kinase
PA
palmitic acid
PCOS
polycystic ovary syndrome
PGC-1α
peroxisome proliferator-activated receptor-g coactivator-1α
PI3K
phosphatidylinositol 3-kinase
PKB
protein kinase B
PKC
protein kinase C
PPARα
peroxisome-proliferator activated receptor α
PTP
permeability transition pore
RCT
randomized controlled trial
RISK
reperfusion injury salvage kinase
ROS
reactive oxygen species
SERCA2
reticulum sarcoplasmic Ca2 +-ATPase
RISK
reperfusion injury salvage kinase
Smad3
mothers against decapentaplegic homolog 3
SRC-2
steroid receptor coactivator 2
T1DM
Type 1 diabetes mellitus
T2DM
Type 2 diabetes mellitus
TGFβ1
transforming growth factor β1
TLR4
Toll-like receptor
TNF-α
tumor necrosis factor α
TR4
testicular receptor 4
UKPDS
United Kingdom Prospective Diabetes Study
VLDL
very low density lipoprotein
Metformin
Pancreatic β Cells
Heart failure
Insulin sensitizer
Effect of flexible linker length on the activity of fusion protein 4-coumaroyl-CoA ligase:: stilbene synthase
期刊论文
MOLECULAR BIOSYSTEMS, 2017, 卷号: 13, 期号: 3, 页码: 598-606
作者:
Guo, HL
;
Yang, YD
;
Xue, FY
;
Zhang, H
;
Huang, TR
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2017/12/31
Molecular basis of antibody binding to mucin glycopeptides in lung cancer
期刊论文
INTERNATIONAL JOURNAL OF ONCOLOGY, 2016, 卷号: 48, 期号: 2, 页码: 587-594
作者:
Qu, Jin
;
Yu, Hongtao
;
Li, Fenge
;
Zhang, Chunlei
;
Trad, Ahmad
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
lung cancer
glycoproteome
glycopeptidome
monoclonal antibody
mucin
Tn antigen
sialyl-Tn antigen
cancer biomarkers
cancer vaccine
immunotherapy
immunodiagnosis
immunomonitoring
长牡蛎甲状腺激素及其信号通路关键基因的功能研究
学位论文
博士, 北京: 中国科学院大学, 2015
作者:
黄雯
收藏
  |  
浏览/下载:81/0
  |  
提交时间:2015/06/05
长牡蛎
甲状腺激素
核受体
A pH-responsive cell-penetrating peptide-modified liposomes with active recognizing of integrin alpha(v)beta(3) for the treatment of melanoma
期刊论文
JOURNAL OF CONTROLLED RELEASE, 2015, 卷号: 217
作者:
Shi, Kairong
;
Li, Jianping
;
Cao, Zhonglian
;
Yang, Ping
;
Qiu, Yue
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/19
TR peptide
TH peptide
c(RGDfK) peptide
Integrin alpha(v)beta(3)-overexpessing B16F10
Tumor therapy
Cell Membrane Tracker Based on Restriction of Intramolecular Rotation
期刊论文
ACS APPLIED MATERIALS & INTERFACES, 2014, 卷号: 6, 页码: 8971-8975
作者:
Zhang, Chunqiu
;
Jin, Shubin
;
Yang, Keni
;
Xue, Xiangdong
;
Li, Zhipeng
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2018/07/05
Cell Membrane
Tracker
Tetraphenylethylene (Tpe)
Restriction Of Intramolecular Rotation (Rir)
A C-Terminal Proline-Rich Sequence Simultaneously Broadens the Optimal Temperature and pH Ranges and Improves the Catalytic Efficiency of Glycosyl Hydrolase Family 10 Ruminal Xylanases
期刊论文
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2014, 卷号: 80, 期号: 11, 页码: 3426-3432
作者:
Li, Zhongyuan
;
Xue, Xianli
;
Zhao, Heng
;
Yang, Peilong
;
Luo, Huiying
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2016/06/23
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