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JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers
期刊论文
CANCER LETTERS, 2024, 卷号: 582, 页码: 15
作者:
Lu, Xuxiu
;
Yu, Rilei
;
Li, Zhen
;
Yang, Mengke
;
Dai, Jiajia
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2024/04/07
Acquired resistance
Cancer
NSCLC
JC-010a
SHP2
Profiling Receptor Tyrosine Kinase Fusions in Chinese Breast Cancers
期刊论文
FRONTIERS IN ONCOLOGY, 2021, 卷号: 11
作者:
Tao, Zhonghua
;
Liu, Jianxia
;
Li, Ting
;
Xu, Hong
;
Chen, Kai
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2022/01/10
receptor tyrosine kinase
gene fusion
genomic rearrangments
breast cancer
next-generation sequencing
Activation and function of receptor tyrosine kinases in human clear cell renal cell carcinomas
期刊论文
BMC CANCER, 2019, 卷号: 19, 期号: 1, 页码: 13
作者:
Zhang, Qing
;
Liu, Jian-He
;
Liu, Jing-Li
;
Qi, Chun-Ting
;
Yan, Lei
收藏
  |  
浏览/下载:61/0
  |  
提交时间:2020/07/01
Receptor tyrosine kinases (RTKs)
Activation and function
Clear cell renal cell carcinomas (ccRCCs)
Targeted therapy
PDGFR beta
Stroma cells
Survivin-targeting miR-542-3p overcomes HER3 signaling-induced chemoresistance and enhances the antitumor activity of paclitaxel against HER2-overexpressing breast cancer
期刊论文
Cancer Letters, 2018, 卷号: 420, 页码: 97-108
作者:
Lyu, Hui
;
Wang, Shuiliang
;
Huang, Jingcao
;
Wang, Bolun
;
He, Zhimin
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/12/03
HER3
Survivin
miRNA
Paclitaxel resistance
Breast cancer
RTKs
Receptor tyrosine kinases
PI-3K
Phosphoinositide 3-kinase
CHX
Cycloheximide
ELISA
Enzyme-linked immunosorbent assay
IHC
Immunohistochemistry
i.p.
Intraperitoneal
Concomitant inhibition of receptor tyrosine kinases and downstream AKT synergistically inhibited growth of KRAS/BRAF mutant colorectal cancer cells
期刊论文
ONCOTARGET, 2017, 卷号: 8, 期号: 3, 页码: 5003-5015
作者:
Song, Qiaoling
;
Sun, Xiaoxiao
;
Guo, Hui
;
Yu, Qiang
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
receptor tyrosine kinases
AKT
colorectal cancer
drug combination
RAS/RAF
Integration of Receptor Tyrosine Kinases Determines Sensitivity to PI3K alpha-selective Inhibitors in Breast Cancer
期刊论文
THERANOSTICS, 2017, 卷号: 7, 期号: 4, 页码: 974-986
作者:
Xu, Yi-chao
;
Wang, Xiang
;
Chen, Yi
;
Chen, Si-meng
;
Yang, Xin-ying
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
BYL719
PI3K
ERK
receptor tyrosine kinase
breast cancer
predictive biomarker
Receptor Tyrosine Kinase Phosphorylation Pattern-Based Multidrug Combination Is an Effective Approach for Personalized Cancer Treatment
期刊论文
MOLECULAR CANCER THERAPEUTICS, 2016, 卷号: 15, 期号: 10, 页码: 2508-2520
作者:
Sun, Xiaoxiao
;
Song, Qiaoling
;
He, Li
;
Yan, Lei
;
Liu, Jingli
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
Co-expression modules of NF1, PTEN and sprouty enable distinction of adult diffuse gliomas according to pathway activities of receptor tyrosine kinases
期刊论文
ONCOTARGET, 2016
Zhang, Wanyu
;
Lv, Yuhong
;
Xue, Yang
;
Wu, Chenxing
;
Yao, Kun
;
Zhang, Chuanbao
;
Jin, Qiang
;
Huang, Rong
;
Li, Jiuyi
;
Sun, Yingyu
;
Su, Xiaodong
;
Jiang, Tao
;
Fan, Xiaolong
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2017/12/04
glioma
molecular classification
receptor tyrosine kinase
HUMAN GLIOBLASTOMA CELLS
HIGH-GRADE GLIOMA
TUMOR ANGIOGENESIS
MALIGNANT GLIOMAS
HUMAN-DISEASE
EXPRESSION
PROGRESSION
LANDSCAPE
PDGFRA
EGFR
EphA7 modulates apical constriction of hindbrain neuroepithelium during neurulation in Xenopus
期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2016, 卷号: 479, 期号: X, 页码: 759-765
作者:
Wang XL
;
Sun J
;
Li CC
;
Mao BY[*]
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2016/10/17
Apical constriction
EphA7
Focal adhesion kinase
Neurulation
Xenopus
MicroRNAs in tumor angiogenesis
期刊论文
LIFE SCIENCES, 2015, 卷号: 136, 页码: 28-35
作者:
Wang, WF
;
Zhang, ED
;
Lin, CJ
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2017/01/13
Tumor angiogenesis
MicroRNAs
Vascular endothelial growth factor (VEGF)
Thrombospondin-1 (TSP-1)
Receptor tyrosine kinases (RTKs)
Hypoxia inducible factor (HIF)
Reactive oxygen species (ROS)
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