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上海药物研究所 [6]
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期刊论文 [12]
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Pamiparib Monotherapy for Patients with Germline BRCA1/2-Mutated Ovarian Cancer Previously Treated with at Least Two Lines of Chemotherapy: A Multicenter, Open-Label, Phase II Study
期刊论文
CLINICAL CANCER RESEARCH, 2022, 卷号: 28
作者:
Wu, Xiaohua
;
Zhu, Jianqing
;
Wang, Jing
;
Lin, Zhongqiu
;
Yin, Rutie
收藏
  |  
浏览/下载:105/0
  |  
提交时间:2022/03/28
Novel poly (ADP-ribose) polymerases inhibitor DHC-1 exhibits in vitro and in vivo anticancer activity on BRCA-deficient pancreatic cancer cells
期刊论文
FOOD AND CHEMICAL TOXICOLOGY, 2021, 卷号: 147, 页码: 10
作者:
Wu, Xiaochen
;
Li, Qiqi
;
Zhang, Fan
;
Wang, Lijun
;
Wang, Jun
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2021/04/21
PARP inhibitor
BRCA
Pancreatic cancer
TSL-1502, a glucuronide prodrug of a poly (ADP-ribose) polymerase (PARP) inhibitor, exhibits potent anti-tumor activity in preclinical models
期刊论文
AMERICAN JOURNAL OF CANCER RESEARCH, 2021, 卷号: 11, 期号: 4, 页码: 1632-1645
作者:
Wang, Lei
;
Zhu, Xi
;
Li, Lili
;
Li, Lin
;
Fu, Li
收藏
  |  
浏览/下载:77/0
  |  
提交时间:2021/06/11
PARP
DNA damage
hematologic toxicity
beta-glucuronidase
tumor selectivity
Identification of 2-substituted pyrrolo[1,2-b]pyridazine derivatives as new PARP-1 inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2021, 卷号: 31, 页码: 4
作者:
Xiang, Hao-Yue
;
Chen, Jian-Yang
;
Huan, Xia-Juan
;
Chen, Yi
;
Gao, Zhao-bing
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2021/05/24
Antiproliferative
Cancer
PARP inhibitors
Pyrrolo[12-b]pyridazine
Discovery and biological evaluation of N-(3-(7-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-methyl-2-oxo-2H-pyrimido[4,5-d][1,3]oxazin-1(4H)-yl)phenyl)acrylamide as potent Bruton's tyrosine kinase inhibitors
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 卷号: 41, 期号: 3, 页码: 415-422
作者:
Lai, Meng-zhen
;
Song, Pei-ran
;
Dou, Dou
;
Diao, Yan-yan
;
Tong, Lin-jiang
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2020/07/01
B cell receptor
Bruton's tyrosine kinase
ibrutinib
small-molecule inhibitor
B cell malignancies
discoveryandbiologicalevaluationofn372methoxy44methylpiperazin1ylphenylamino4methyl2oxo2hpyrimido45d13oxazin14hylphenylacrylamideaspotentbrutonstyrosinekinaseinhibitors
期刊论文
actapharmacologicasinica, 2020, 卷号: 41, 期号: 3, 页码: 415
作者:
Lai Mengzhen
;
Song Peiran
;
Dou Dou
;
Diao Yanyan
;
Tong Linjiang
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2020/07/01
B cell receptor
Bruton’s tyrosine kinase
ibrutinib
small-molecule inhibitor
B cell malignancies
PI3K alpha inhibitors sensitize esophageal squamous cell carcinoma to radiation by abrogating survival signals in tumor cells and tumor microenvironment
期刊论文
CANCER LETTERS, 2019, 卷号: 459, 页码: 145-155
作者:
Shi, Jia-jie
;
Xing, Hui
;
Wang, Yu-xiang
;
Zhang, Xi
;
Zhan, Qi-min
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2020/07/01
CYH33
Radiation
Synergism
ESCC
PI3K alpha
Identification of amentoflavone as a potent highly selective PARP-1 inhibitor and its potentiation on carboplatin in human non-small cell lung cancer
期刊论文
2018, 卷号: 50, 页码: 88
作者:
Hu Xiao-Long[1]
;
Feng, Jia-Hao[1]
;
Thi-Anh Pham[1]
;
Ma, Hai-Yan[1]
;
Ma, Ming-Xi[2]
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/23
Discovery of novel quinazoline-2,4(1H,3H)-dione derivatives as potent PARP-2 selective inhibitors
期刊论文
2017, 卷号: 25, 期号: 15, 页码: 4045-4054
作者:
Zhao, Hailong
;
Ji, Ming
;
Cui, Guonan
;
Zhou, Jie
;
Lai, Fangfang
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2020/01/04
Quinazoline-2
4(1H
3H)-dione
PARP-2 selective inhibitor
Anti-tumor agents
Poly(ADP-ribose) polymerase inhibitors as promising cancer therapeutics
期刊论文
ACTA PHARMACOLOGICA SINICA, 2010, 卷号: 31, 期号: 9, 页码: 1172-1180
作者:
He, Jin-xue
;
Yang, Chun-hao
;
Miao, Ze-hong
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
poly(ADP-ribose) polymerase inhibitor
DNA repair
BRCA1/2
anticancer agents
homologous recombination
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