Poly(ADP-ribose) polymerase inhibitors as promising cancer therapeutics

doi:10.1038/aps.2010.103

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	Poly(ADP-ribose) polymerase inhibitors as promising cancer therapeutics
	He, Jin-xue 1; Yang, Chun-hao2 ; Miao, Ze-hong 1
刊名	ACTA PHARMACOLOGICA SINICA
	2010-09
卷号	31 期号:9 页码:1172-1180
关键词	poly(ADP-ribose) polymerase inhibitor DNA repair BRCA1/2 anticancer agents homologous recombination
ISSN号	1671-4083
DOI	10.1038/aps.2010.103
文献子类	Review
英文摘要	The year of 2005 was a watershed in the history of poly(ADP-ribose) polymerase (PARP) inhibitors due to the important findings of selective killing in BRCA-deficient cancers by PARP inhibition. The findings made PARP inhibition one of the most promising new therapeutic approaches to cancers, especially to those with specific defects. With AZD2281 and BSI-201 entering phase III clinical trials, the final application of PARP inhibitors in clinic would come true soon. This current paper will review the major advances in targeting PARP for cancer therapy and discuss the existing questions, the answers to which may influence the future of PARP inhibitors as cancer therapeutics.
资助项目	National Natural Science Foundation of China (NSFC)[30772588] ; National Natural Science Foundation of China (NSFC)[30721005] ; National Science & Technology of China[2009ZX09301-001] ; Science and Technology Commission of Shanghai Municipality (STCSM)[08DZ1980200]
WOS关键词	DNA-REPAIR ; PARP INHIBITORS ; CATALYTIC FRAGMENT ; TELOMERE LENGTH ; MAMMARY-TUMORS ; MUTANT-CELLS ; DAMAGE ; TRF1 ; COMBINATION ; DEFICIENCY
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
CSCD记录号	CSCD:3989620
出版者	ACTA PHARMACOLOGICA SINICA
WOS记录号	WOS:000281562900024
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/278782]
专题	药理学第一研究室中科院受体结构与功能重点实验室新药研究国家重点实验室药物化学研究室
通讯作者	Miao, Ze-hong
作者单位	1.Chinese Acad Sci, Div Antitumor Pharmacol, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Dept Med Chem, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	He, Jin-xue,Yang, Chun-hao,Miao, Ze-hong. Poly(ADP-ribose) polymerase inhibitors as promising cancer therapeutics[J]. ACTA PHARMACOLOGICA SINICA,2010,31(9):1172-1180.
APA	He, Jin-xue,Yang, Chun-hao,&Miao, Ze-hong.(2010).Poly(ADP-ribose) polymerase inhibitors as promising cancer therapeutics.ACTA PHARMACOLOGICA SINICA,31(9),1172-1180.
MLA	He, Jin-xue,et al."Poly(ADP-ribose) polymerase inhibitors as promising cancer therapeutics".ACTA PHARMACOLOGICA SINICA 31.9(2010):1172-1180.