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上海药物研究所 [19]
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期刊论文 [28]
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Discovery of chiral N-2 '-aryletheryl-1 '-alkoxy-ethyl substituted arylisoquinolones with anti-inflammatory activity from the nucleophilic addition reactions of the thiophenols and oxazolinium
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 222, 页码: 11
作者:
Li, Bo
;
Li, Heng
;
Zhu, Zhengdan
;
Xiang, Caigui
;
Xu, Zhijian
收藏
  |  
浏览/下载:105/0
  |  
提交时间:2021/11/04
Anti-inflammatory activity
TNF alpha
ER beta
IBD Arylisoquinolones
Discovery of novel ketoxime ether derivatives with potent FXR agonistic activity, oral effectiveness and high liver/blood ratio
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 43, 页码: 13
作者:
Tang, Xuehang
;
Ning, Mengmeng
;
Ye, Yangliang
;
Gu, Yipei
;
Yan, Hongyi
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2021/11/04
FXR agonist
Ketoxime ether
Target genes
Liver
blood ratio
Systemic activation
Myeloid Cell mPges-1 Deletion Attenuates Mortality Without Affecting Remodeling After Acute Myocardial Infarction in Mice
期刊论文
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2019, 卷号: 370, 页码: 18-24
作者:
Chen, Lihong
;
Yang, Guangrui
;
Jiang, Tingting
;
Tang, Soon Yew
;
Wang, Tao
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/02
PGE2,cardiovascular disease,macrophages,non-steroidal anti-inflammatory drugs (NSAIDs),prostaglandins
Unusual Cytotoxic Steroidal Saponins from the Gorgonian Astrogorgia dumbea
期刊论文
PLANTA MEDICA, 2016, 卷号: 82, 期号: 9-10, 页码: 882-887
作者:
Lu, Ya-Nan
;
Cui, Ping
;
Tian, Xiao-Qing
;
Lou, Li-Guang
;
Fan, Cheng-Qi
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/01/08
Astrogorgia dumbea
Plexauridae
steroidal saponin
astrogorgiosides A-C
cytotoxic activity
Discovery and SAR study of 3-(tert-butyl)-4-hydroxyphenyl benzoate and benzamide derivatives as novel farnesoid X receptor (FXR) antagonists
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2015, 卷号: 23, 期号: 19, 页码: 6427-6436
作者:
Song, Kebiao
;
Xu, Xing
;
Liu, Peng
;
Chen, Lili
;
Shen, Xu
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2019/01/08
FXR
FXR antagonist
SAR study
Non-steroidal
Discovery of New Non-Steroidal Farnesoid X Receptor Modulators Through 3D Shape Similarity Search and Structure-Based Virtual Screening
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2015, 卷号: 85, 期号: 4, 页码: 481-487
作者:
Wang, Lei
;
Si, Pei
;
Sheng, Yayun
;
Chen, Yingjie
;
Wan, Ping
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/01/08
farnesoid X receptor
modulators
similarity search
virtual screening
FXR antagonism of NSAIDs contributes to drug-induced liver injury identified by systems pharmacology approach
期刊论文
SCIENTIFIC REPORTS, 2015, 卷号: 5
作者:
Lu, Weiqiang
;
Cheng, Feixiong
;
Jiang, Jing
;
Zhang, Chen
;
Deng, Xiaokang
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/01/08
Effects of aspirin on immobile behavior and endocrine and immune changes in the forced swimming test: Comparison to fluoxetine and imipramine
期刊论文
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2014, 卷号: 124, 期号: 0, 页码: 361-366
作者:
Guan, Xi-ting
;
Shao, Feng
;
Xie, Xi
;
Chen, Lin
;
Wang, Weiwen
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2015/09/18
Aspirin
Antidepressant
Forced swimming test
Corticosterone
IL-6
TNF-alpha
Discovery and SAR study of hydroxyacetophenone derivatives as potent, non-steroidal farnesoid X receptor (FXR) antagonists
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 卷号: 22, 期号: 5, 页码: 1596-1607
作者:
Liu, Peng
;
Xu, Xing
;
Chen, Lili
;
Ma, Lei
;
Shen, Xu
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
FXR antagonist
SAR study
Hydroxyacetophenone derivatives
Non-steroidal
Effects of aspirin on immobile behavior and endocrine and immune changes in the forced swimming test: Comparison to fluoxetine and imipramine
期刊论文
pharmacology biochemistry and behavior, 2014
Guan, Xi-ting
;
Shao, Feng
;
Xie, Xi
;
Chen, Lin
;
Wang, Weiwen
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2015/11/11
Aspirin
Antidepressant
Forced swimming test
Corticosterone
IL-6
TNF-alpha
NECROSIS-FACTOR-ALPHA
STRESS-INDUCED INCREASE
MAJOR DEPRESSION
ACETYLSALICYLIC-ACID
ANTIDEPRESSANT TREATMENTS
INFLAMMATORY MARKERS
ANTIINFLAMMATORY DRUGS
DESIPRAMINE TREATMENT
REUPTAKE INHIBITORS
MONOAMINE REUPTAKE
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