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期刊论文 [48]
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Dezocine as a potent analgesic: overview of its pharmacological characterization
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 12
作者:
Ye, Rong-Rong
;
Jiang, Shuang
;
Xu, Xu
;
Lu, Yan
;
Wang, Yu-Jun
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2021/12/16
dezocine
opioid receptors
norepinephrine
serotonin transporter
postoperative pain
anesthesia
Novel selective kappa agonists SLL-039 and SLL-1206 produce potent antinociception with fewer sedation and aversion
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:
Wei, Yuan-yuan
;
Ma, Yan
;
Yao, Song-yu
;
Kong, Ling-hui
;
Liu, Xiao
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2021/11/04
kappa-opioid receptor agonist
4,5-expoxymorphinan
antinociception
conditioned place aversion
sedation
U50,488H
morphine
Nor-BNI
beta-FNA
Discovery of an M-Substituted N-Cyclopropylmethyl-7 alpha-phenyl-6,14-endoethanotetrahydronorthebaine as a Selective, Potent, and Orally Active kappa-Opioid Receptor Agonist with an Improved Central Nervous System Safety Profile
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 16, 页码: 12414-12433
作者:
He, Qian
;
Wei, Yuanyuan
;
Liu, Xiao
;
Ye, Rongrong
;
Kong, Linghui
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  |  
浏览/下载:90/0
  |  
提交时间:2021/11/04
Discovery of 3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxypheny1)-N-phenylpiperidine-1-carboxamide as novel potent analgesic
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 189, 页码: 14
作者:
Huang, Huoming
;
Wang, Wenli
;
Xu, Xuejun
;
Zhu, Chen
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  |  
浏览/下载:36/0
  |  
提交时间:2020/07/01
Selective MOR agonists
Antinociception
Analgesic
Opioids
Molecular mechanism
Discovery of a Highly Selective and Potent kappa Opioid Receptor Agonist from N-Cyclopropylmethyl-7 alpha-phenyl-6,14-endoethanotetrahydronorthebaines with Reduced Central Nervous System (CNS) Side Effects Navigated by the Message-Address Concept
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 24, 页码: 11054-11070
作者:
Xiao, Li
;
Wang, Yujun
;
Zhang, Mumei
;
Wu, Weiwei
;
Kong, Linghui
收藏
  |  
浏览/下载:93/0
  |  
提交时间:2020/07/01
Pharmacological Characterization of Dezocine, a Potent Analgesic Acting as a kappa Partial Agonist and mu Partial Agonist
期刊论文
SCIENTIFIC REPORTS, 2018, 卷号: 8
作者:
Wang, Yu-Hua
;
Chai, Jing-Rui
;
Xu, Xue-Jun
;
Ye, Ru-Feng
;
Zan, Gui-Ying
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  |  
浏览/下载:94/0
  |  
提交时间:2019/01/08
Porcine diazepam-binding inhibitor and bovine diazepam-binding inhibitor affect morphine antinociception via different receptors
期刊论文
蛋白质与细胞, 2017
Yu-Zhen Chen
;
Xiao-Cun Li
;
Zhen-Quan Guo
;
Song-Ping Liang
;
Cai-Hong Wu
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2017/12/03
inhibitor
diazepam-binding
Porcine
POLYPEPTIDE
Influences of Morphine on the Spontaneous and Evoked Excitatory Postsynaptic Currents in Lateral Amygdala of Rats
期刊论文
PHYSIOLOGICAL RESEARCH, 2016
Zhang, Jian-Jun
;
Liu, Xiao-Dong
;
Yu, Long-Chuan
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2017/12/03
Discharge frequency
Excitatory synaptic transmission
Evoked excitatory postsynaptic currents (eEPSCs)
Lateral amygdala
Morphine
Spontaneous excitatory postsynaptic currents (sEPSCs)
TAIL-FLICK REFLEX
CENTRAL NUCLEUS
BASOLATERAL AMYGDALA
RECEPTOR SUBUNIT
CORTEX
ANTINOCICEPTION
MICROINJECTION
CONTRIBUTES
INHIBITION
WITHDRAWAL
Influences of Morphine on the Spontaneous and Evoked Excitatory Postsynaptic Currents in Lateral Amygdala of Rats
期刊论文
PHYSIOLOGICAL RESEARCH, 2016
Zhang, Jian-Jun
;
Liu, Xiao-Dong
;
Yu, Long-Chuan
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2017/12/03
Discharge frequency
Excitatory synaptic transmission
Evoked excitatory postsynaptic currents (eEPSCs)
Lateral amygdala
Morphine
Spontaneous excitatory postsynaptic currents (sEPSCs)
TAIL-FLICK REFLEX
CENTRAL NUCLEUS
BASOLATERAL AMYGDALA
RECEPTOR SUBUNIT
CORTEX
ANTINOCICEPTION
MICROINJECTION
CONTRIBUTES
INHIBITION
WITHDRAWAL
Influences of Morphine on the Spontaneous and Evoked Excitatory Postsynaptic Currents in Lateral Amygdala of Rats
期刊论文
PHYSIOLOGICAL RESEARCH, 2016, 卷号: 65, 期号: 1, 页码: 165-169
作者:
Zhang, Jian-Jun
;
Liu, Xiao-Dong
;
Yu, Long-Chuan
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2016/07/14
Discharge frequency
Excitatory synaptic transmission
Evoked excitatory postsynaptic currents (eEPSCs)
Lateral amygdala
Morphine
Spontaneous excitatory postsynaptic currents (sEPSCs)
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