Influences of Morphine on the Spontaneous and Evoked Excitatory Postsynaptic Currents in Lateral Amygdala of Rats

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	Influences of Morphine on the Spontaneous and Evoked Excitatory Postsynaptic Currents in Lateral Amygdala of Rats
	Zhang, Jian-Jun1,2,3 ; Liu, Xiao-Dong 2,3; Yu, Long-Chuan 2,3
刊名	PHYSIOLOGICAL RESEARCH
	2016
卷号	65 期号:1 页码:165-169
关键词	Discharge frequency Excitatory synaptic transmission Evoked excitatory postsynaptic currents (eEPSCs) Lateral amygdala Morphine Spontaneous excitatory postsynaptic currents (sEPSCs)
ISSN号	0862-8408
英文摘要	Acute morphine exposure induces antinociceptive activity, but the underlying mechanisms in the central nervous system are unclear. Using whole-cell patch clamp recordings, we explore the role of morphine in the modulation of excitatory synaptic transmission in lateral amygdala neurons of rats. The results demonstrate that perfusion of 10 mu M of morphine to the lateral amygdala inhibits the discharge frequency significantly. We further find that there are no significant influences of morphine on the amplitude of spontaneous excitatory postsynaptic currents (sEPSCs). Interestingly, morphine shows no marked influence on the evoked excitatory postsynaptic currents (eEPSCs) in the lateral amygdala neurons. These results indicate that acute morphine treatment plays an important role in the modulation on the excitatory synaptic transmission in lateral amygdala neurons of rats.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Physiology
研究领域[WOS]	Physiology
关键词[WOS]	TAIL-FLICK REFLEX ; CENTRAL NUCLEUS ; BASOLATERAL AMYGDALA ; RECEPTOR SUBUNIT ; CORTEX ; ANTINOCICEPTION ; MICROINJECTION ; CONTRIBUTES ; INHIBITION ; WITHDRAWAL
收录类别	SCI
语种	英语
WOS记录号	WOS:000377529800017
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/19953]
专题	心理研究所_中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Peking Univ, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100871, Peoples R China 3.Peking Univ, Neurobiol Lab, Coll Life Sci, Beijing 100871, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Jian-Jun,Liu, Xiao-Dong,Yu, Long-Chuan. Influences of Morphine on the Spontaneous and Evoked Excitatory Postsynaptic Currents in Lateral Amygdala of Rats[J]. PHYSIOLOGICAL RESEARCH,2016,65(1):165-169.
APA	Zhang, Jian-Jun,Liu, Xiao-Dong,&Yu, Long-Chuan.(2016).Influences of Morphine on the Spontaneous and Evoked Excitatory Postsynaptic Currents in Lateral Amygdala of Rats.PHYSIOLOGICAL RESEARCH,65(1),165-169.
MLA	Zhang, Jian-Jun,et al."Influences of Morphine on the Spontaneous and Evoked Excitatory Postsynaptic Currents in Lateral Amygdala of Rats".PHYSIOLOGICAL RESEARCH 65.1(2016):165-169.