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CORC

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Lead discovery, chemical optimization, and biological evaluation studies of novel histone methyltransferase SET7 small-molecule inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 9, 页码: 10
作者:  Hou, Zeng;  Min, Wenjian;  Zhang, Rukang;  Niu, Ao;  Li, Yuanqing
收藏  |  浏览/下载：46/0  |  提交时间：2020/07/01
Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses 期刊论文
NATURE COMMUNICATIONS, 2019, 卷号: 10
作者:  Jiang, Yuhang;  Li, Cuifeng;  Wu, Qian;  An, Peng;  Huang, Laiquan
收藏  |  浏览/下载：62/0  |  提交时间：2019/12/05
Arabidopsis histone H3K4 demethylase JMJ17 functions in dehydration stress response 期刊论文
NEW PHYTOLOGIST, 2019, 卷号: 223, 期号: 3, 页码: 1372-1387
作者:  Huang, Shuangzhan;  Zhang, Ai;  Jin, Jing Bo;  Zhao, Bo;  Wang, Tian-Jing
收藏  |  浏览/下载：24/0  |  提交时间：2022/01/06
Discovery of KDM5A inhibitors: Homology modeling, virtual screening and structure-activity relationship analysis. 期刊论文
Bioorg Med Chem Lett, 2016, 卷号: Vol.26 No.9, 页码: 2284-2288
作者:  Wu, Xiaoai;  Fang, Zhen;  Yang, Bo;  Zhong, Lei;  Yang, Qiuyuan
收藏  |  浏览/下载：5/0  |  提交时间：2019/02/27
Epigenetic targets and drug discovery Part 2: Histone demethylation and DNA methylation 期刊论文
Pharmacology and Therapeutics, 2015, 卷号: 151, 页码: 121-140
作者:  Liu, Ke;  Liu, Yanli;  Lau, Johnathan L;  Min, Jinrong*
收藏  |  浏览/下载：13/0  |  提交时间：2019/12/23
Histone demethylation  DNA methylation  Inhibitor  Chemical probe  Drug discovery  LSD  lysine-specific histone demethylase  HDAC  histone deacetylase  REST  REST corepressor  DNMT  DNA methyltransferase  MAO  monoamine oxidase  AML  acute myeloid leukemia  KDM  lysine-specific demethylase  MLL  mixed lineage leukemia  FAD  flavin adenine dinucleotide  PCPA  trans-2-phenylcyclopropylamine  2,4-PDCA  2, 4-pyridinedicarboxylic acid  PHD  plant homeobox domain  SCLC  small cell lung cancer  JHDMs  JmjC-domain-containing histone demethylases  NOG  N-oxalylglycine  IOX1  5-carboxy-8-hydroxyquinoline  MDS  myelodysplastic syndrome  2-OG, 2-oxoglutarate or  α-ketoglutarate  G9a  euchromatic histone-lysine N-methyltransferase 2  CoREST complex  restin corepressor complex  SAH  S-adenosyl-l-homocysteine  l  SWI complex  ATP dependent chromatin remodeling complexes  Pan-Histone Demethylase Inhibitor  the inhibitor can simultaneously inhibit both LSDs and JHDMs  LSC colony  leukemic stem cell colony  Pan JmjC domain-containing demethylase inhibitor  the inhibitor can simultaneously inhibit all the members of JHDMs  E2F1  E2F transcription factor 1  E2F2  E2F transcription factor 2  RCC  renal cell carcinoma  
The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B 期刊论文
PROTEIN & CELL, 2014, 卷号: 5, 期号: 11, 页码: 837-850
作者:  Zhang, Yan;  Yang, Huirong;  Guo, Xue;  Rong, Naiyan;  Song, Yujiao
收藏  |  浏览/下载：22/0  |  提交时间：2015/06/24
The DNA methylation landscape of human early embryos 期刊论文
nature, 2014
Guo, Hongshan; Zhu, Ping; Yan, Liying; Li, Rong; Hu, Boqiang; Lian, Ying; Yan, Jie; Ren, Xiulian; Lin, Shengli; Li, Junsheng; Jin, Xiaohu; Shi, Xiaodan; Liu, Ping; Wang, Xiaoye; Wang, Wei; Wei, Yuan; Li, Xianlong; Guo, Fan; Wu, Xinglong; Fan, Xiaoying; Yong, Jun; Wen, Lu; Xie, Sunney X.; Tang, Fuchou; Qiao, Jie
收藏  |  浏览/下载：2/0  |  提交时间：2015/11/13
Pluripotent Stem Cell Protein Sox2 Confers Sensitivity to LSD1 Inhibition in Cancer Cells 期刊论文
cell reports, 2013
Zhang, Xiaoming; Lu, Fei; Wang, Jing; Yin, Feng; Xu, Zhengshuang; Qi, Dandan; Wu, Xianhui; Cao, Yuwen; Liang, Weihua; Liu, Yuqing; Sun, Hong; Ye, Tao; Zhang, Hui
收藏  |  浏览/下载：3/0  |  提交时间：2015/11/11
Prox1 Directly Interacts with LSD1 and Recruits the LSD1/NuRD Complex to Epigenetically Co-Repress CYP7A1 Transcription 期刊论文
PLOS ONE, 2013, 卷号: 8, 期号: 4, 页码: e62192-e62192
作者:  Ouyang, HF;  Qin, Y;  Liu, YF;  Xie, YH;  Liu, J
收藏  |  浏览/下载：22/0  |  提交时间：2015/07/22
Histone Lysine-specific Demethylase 1 (LSD1) Protein Is Involved in Sal-like Protein 4 (SALL4)-mediated Transcriptional Repression in Hematopoietic Stem Cells 期刊论文
2013, 卷号: 288, 期号: 48, 页码: 34719-34728
作者:  Liu, Li;  Souto, Joseph;  Liao, Wenbin;  Jiang, Yongping;  Li, Yangqiu
收藏  |  浏览/下载：2/0  |  提交时间：2020/01/13

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