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Synthesis and Biological Activities of Dihydrooxazolo[5,4-d]- pyrrolo[1,2-a]pyrimidinones
期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2022, 卷号: 42, 期号: 2, 页码: 543-556
作者:
Zeng, Y (Zeng Yan) [1] , [2]
;
Nie, LF (Nie Lifei) [1]
;
Niu, C (Niu Chao) [1]
;
Mamatjan, A (Mamatjan Aytilla) [1] , [2]
;
Bozorov, K (Bozorov Khurshed) [1]
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2022/05/17
oxazopyrimidinone
synthesis
bioisosterism
anticancer activity
antimicrobial activity
structure-activity relationships (SARs)
Ropivacaine suppresses tumor biological characteristics of human hepatocellular carcinoma via inhibiting IGF-1R/PI3K/AKT/mTOR signaling axis
期刊论文
BIOENGINEERED, 2021, 卷号: 12
作者:
Zhang, Runze
;
Lian, Yanhong
;
Xie, Kangjie
;
Cai, Yunfang
;
Pan, Yafei
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  |  
浏览/下载:39/0
  |  
提交时间:2022/01/10
Ropivacaine
hepatocellular carcinoma
IGF-1R
IGF1R-PI3K-AKT-mTOR signaling
cell cycle
epithelial-mesenchymal transition
Design, synthesis and biological evaluation of novel thiohydantoin derivatives as potent androgen receptor antagonists for the treatment of prostate cancer
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 31, 页码: 13
作者:
Wang, Ao
;
Wang, Yawan
;
Meng, Xin
;
Yang, Yushe
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2021/05/24
Androgen receptor
Novel thiohydantoin derivatives
Androgen receptor antagonists
Prostate cancer
Erectsterates A and B, a pair of novel highly degraded steroid derivatives from the South China Sea soft coral Sinularia erecta
期刊论文
STEROIDS, 2020, 卷号: 161, 页码: 5
作者:
Liu, Jiao
;
Wu, Xin
;
Yang, Min
;
Gu, Yu-Cheng
;
Yao, Li-Gong
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2020/12/24
Sinularia erecta
Steroidal derivative
Cytotoxicity
Baeyer-Villiger oxidation
Design, synthesis and biological evaluation of the thioether-containing lenalidomide analogs with anti-proliferative activities
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 176, 页码: 419-430
作者:
Xiao, Donghuai
;
Wang, Yu-jie
;
Hu, Xiao-bei
;
Kan, Wei-juan
;
Zhang, Qiumeng
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2020/07/01
Lenalidomide
Thioether
Anti-Tumor
Structural modification
Selective ERK1/2 agonists isolated from Melia azedarach with potent anti-leukemic activity
期刊论文
BMC Cancer, 2019, 卷号: 19, 期号: 1
作者:
Wang,Ning
;
Fan,Yanhua
;
Yuan,Chun-Mao
;
Song,Jialei
;
Yao,Yao
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  |  
浏览/下载:86/0
  |  
提交时间:2019/08/13
Cancer
Leukemia
Chinese medicinal plant
Melia azedarach
Drug screen
ERK1/2 agonists
Differentiation
Apoptosis
One Pot and Metal-Free Approach to 3-(2-Hydroxybenzoyl)-1-aza-anthraquinones
期刊论文
MOLECULES, 2019, 卷号: 24, 期号: 16, 页码: 12
作者:
Yuan, Jiaqi
;
He, Qian
;
Song, Shanshan
;
Zhang, Xiaofei
;
Miao, Zehong
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2020/07/01
3-(2-hydroxybenzoyl)-1-aza-anthraquinones
chromones
anti-proliferation agent
Pyrazolo[4,3-b]pyrimido[4,5-e][1,4]diazepine derivatives as new multi-targeted inhibitors of Aurora A/B and KDR
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 158, 页码: 428-441
作者:
Zhang, Qiumeng
;
Shen, Qianqian
;
Gao, Lixin
;
Tong, Linjiang
;
Li, Jia
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2019/01/08
Aurora A
Aurora B
KDR
Multi-targeted
Anticancer
Heterocyclic
Screening for anti-proliferative and anti-inflammatory components from Rhamnus davurica Pall. using bio-affinity ultrafiltration with multiple drug targets
期刊论文
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2018, 卷号: 410, 期号: 15, 页码: 3587-3595
作者:
Guo, Mingquan
;
Wu, Jianlin
;
Chen, Guilin
;
Li, Na
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2018/12/29
Rhamnus davurica
Bio-affinity ultrafiltration
Anti-inflammation
Anti-proliferative
Discovery of novel 2,4-diarylaminopyrimidine derivatives as potent and selective epidermal growth factor receptor (EGFR) inhibitors against L858R/T790M resistance mutation
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 152, 页码: 298-306
作者:
Yan, Qi
;
Chen, Yuzhe
;
Tang, Baiyou
;
Xiao, Qiang
;
Qu, Rong
收藏
  |  
浏览/下载:82/0
  |  
提交时间:2019/01/08
EGFR inhibitors
Pyrimidine derivatives
Mutant selective inhibitors
AZD9291
T790M
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