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上海药物研究所 [10]
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期刊论文 [28]
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Small molecule IVQ, as a prodrug of gluconeogenesis inhibitor QVO, efficiently ameliorates glucose homeostasis in type 2 diabetic mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 9, 页码: 1193-1204
作者:
Zhou, Ting-ting
;
Zhao, Tong
;
Ma, Fei
;
Zhang, Yi-nan
;
Jiang, Jing
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2020/07/01
type 2 diabetes mellitus
hepatic gluconeogenesis
AMPK signaling pathway
(E)-3-(2-(quinoline-4-yl)vinyl)-1H-indol-6-ol (QVO)
4-[2-(1H-indol-3-yl)vinyl]quinoline (IVQ)
prodrug
Cytochrome P450 3A Enzymes Are Key Contributors for Hepatic Metabolism of Bufotalin, a Natural Constitute in Chinese Medicine Chansu
期刊论文
FRONTIERS IN PHARMACOLOGY, 2019, 卷号: 10, 页码: 10
作者:
Ma, Hong-Ping
;
Dai, Zi-Ru
;
Ning, Jing
;
Sun, Gui-Bo
;
Wang, Ping
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  |  
浏览/下载:70/0
  |  
提交时间:2019/06/20
bufotalin
cytochrome P450 3A (CYP3A)
hydroxylation
human liver microsomes (HLMs)
docking simulations
Cytochrome p450 3a enzymes are key contributors for hepatic metabolism of bufotalin, a natural constitute in chinese medicine chansu
期刊论文
Frontiers in pharmacology, 2019, 卷号: 10, 页码: 10
作者:
Dai, Zi-Ru
;
Ning, Jing
;
Sun, Gui-Bo
;
Wang, Ping
;
Zhang, Feng
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  |  
浏览/下载:90/0
  |  
提交时间:2019/05/08
Bufotalin
Cytochrome p450 3a (cyp3a)
Hydroxylation
Human liver microsomes (hlms)
Docking simulations
Inhibition of human CYP3A4 and CYP3A5 enzymes by gomisin C and gomisin G, two lignan analogs derived from Schisandra chinensis
期刊论文
FITOTERAPIA, 2017, 卷号: 119, 页码: 26-31
作者:
Zhao, Jin
;
Sun, Tao
;
Wu, Jing-Jing
;
Cao, Yun-Feng
;
Fang, Zhong-Ze
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2017/10/29
Gomisin c
Gomisin g
Cyp3a4
Cyp3a5
Inhibition
Herb-drug Interactions
Characterization of Phase I Metabolism of Resibufogenin and Evaluation of the Metabolic Effects on Its Antitumor Activity and Toxicity
期刊论文
drug metabolism and disposition, 2015, 卷号: 43, 期号: 3, 页码: 299-308
作者:
Ning, Jing
;
Yu, Zhen-Long
;
Hu, Liang-Hai
;
Wang, Chao
;
Huo, Xiao-Kui
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2015/11/17
Interspecies variation in phase I metabolism of bufalin in hepatic microsomes from mouse, rat, dog, minipig, monkey, and human
期刊论文
XENOBIOTICA, 2015, 卷号: 45, 期号: 11, 页码: 954-960
作者:
Dai, Zi-Ru
;
Yang, Ling
;
Zou, Li-Wei
;
Li, Wei
;
Ma, Xiao-Chi
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/06/20
3-oxidation
5 Beta-hydroxylation
Bufalin
Cytochrome P450 3a
Species Differences
A Formal Synthesis of Betamethasone
期刊论文
Chin. J. Chem., 2015, 卷号: 33, 期号: 6, 页码: 637-642
作者:
Wang SS(王莎莎)
;
Shi Y(史勇)
;
Tian WS(田伟生)
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2016/12/06
Expression, crystallization and preliminary crystallographic data analysis of VioD, a hydroxylase in the violacein-biosynthesis pathway
期刊论文
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2015, 卷号: 71, 页码: 149—152
作者:
Ran, TT
;
Gao, MX
;
Wei, QE
;
He, JH
;
Tang, L
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2015/12/09
CHROMOBACTERIUM-VIOLACEUM
JANTHINOBACTERIUM-LIVIDUM
HETEROLOGOUS EXPRESSION
GENE-CLUSTER
REARRANGEMENT
TRYPANOCIDE
TRYPTOPHAN
MOLECULE
CLONING
Gene cloning, sequence analysis, and expression profiles of a novel beta-ring carotenoid hydroxylase gene from the photoheterotrophic green alga Chlorella kessleri
期刊论文
MOLECULAR BIOLOGY REPORTS, 2014, 卷号: 41, 期号: 11, 页码: 7103-7113
作者:
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2015/07/30
Carotenoid hydroxylase
Chlorella kessleri
Gene cloning
High light
Photoheterotrophic
Facile preparation of Sn-beta zeolites by post-synthesis (isomorphous substitution) method for isomerization of glucose to fructose
期刊论文
chinese journal of catalysis, 2014, 卷号: 35, 期号: 5, 页码: 723-732
作者:
Liu, Min
;
Jia, Songyan
;
Li, Changzeng
;
Zhang, Anfeng
;
Song, Chunshan
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2015/11/17
Sn-beta
Isomorphous substitution
Glucose
Isomerization
Fructose
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