Interspecies variation in phase I metabolism of bufalin in hepatic microsomes from mouse, rat, dog, minipig, monkey, and human

doi:10.3109/00498254.2015.1035359

	Interspecies variation in phase I metabolism of bufalin in hepatic microsomes from mouse, rat, dog, minipig, monkey, and human
	Dai, Zi-Ru 3; Yang, Ling 3; Zou, Li-Wei 3; Li, Wei 4; Ma, Xiao-Chi 5; Ge, Guang-Bo 3; Ning, Jing 2,3; Hou, Jie 1; Wang, Ping 3; Wu, Jing-Jing 3
刊名	XENOBIOTICA
	2015
卷号	45 期号:11 页码:954-960
关键词	3-oxidation 5 Beta-hydroxylation Bufalin Cytochrome P450 3a Species Differences
ISSN号	0049-8254
DOI	10.3109/00498254.2015.1035359
文献子类	Article
英文摘要	1. Bufalin (BF), one of the major bioactive compounds in traditional Chinese medicine (TCM) Chansu, has been found with various pharmacological and toxicological effects. This study aims to investigate the species differences in phase I metabolism of BF in hepatic microsomes from human and five common experimental animals.
WOS关键词	PERFORMANCE LIQUID-CHROMATOGRAPHY ; HUMAN CYTOCHROME-P450 ; MICROBIAL TRANSFORMATION ; SPECIES-DIFFERENCES ; CARDIAC-GLYCOSIDES ; DRUG-METABOLISM ; BUFADIENOLIDES ; INHIBITION ; LIVER ; VITRO
WOS研究方向	Pharmacology & Pharmacy ; Toxicology
语种	英语
出版者	TAYLOR & FRANCIS LTD
WOS记录号	WOS:000369949100002
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/171214]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Ma, Xiao-Chi
作者单位	1.Dalian Med Univ, Dept Biochem & Mol Biol, Dalian 116044, Peoples R China 2.Dalian Med Univ, Dalian 116044, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China 4.Yangzhou Univ, Coll Med, Yangzhou 225009, Jiangsu, Peoples R China 5.Dalian Med Univ, Res Inst Integrated Tradit & Western Med, Western 9 Lvshun South Rd, Dalian 116044, Peoples R China
推荐引用方式 GB/T 7714	Dai, Zi-Ru,Yang, Ling,Zou, Li-Wei,et al. Interspecies variation in phase I metabolism of bufalin in hepatic microsomes from mouse, rat, dog, minipig, monkey, and human[J]. XENOBIOTICA,2015,45(11):954-960.
APA	Dai, Zi-Ru.,Yang, Ling.,Zou, Li-Wei.,Li, Wei.,Ma, Xiao-Chi.,...&Wu, Jing-Jing.(2015).Interspecies variation in phase I metabolism of bufalin in hepatic microsomes from mouse, rat, dog, minipig, monkey, and human.XENOBIOTICA,45(11),954-960.
MLA	Dai, Zi-Ru,et al."Interspecies variation in phase I metabolism of bufalin in hepatic microsomes from mouse, rat, dog, minipig, monkey, and human".XENOBIOTICA 45.11(2015):954-960.