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上海药物研究所 [108]
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期刊论文 [108]
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Acetylcholinesterase-independent protective effects of huperzine A against iron overload-induced oxidative damage and aberrant iron metabolism signaling in rat cortical neurons
期刊论文
ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 11, 页码: 1391-1400
作者:
Tao, Ling-xue
;
Huang, Xiao-tian
;
Chen, Yu-ting
;
Tang, Xi-can
;
Zhang, Hai-yan
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
Alzheimer's disease
huperzine A
iron
reactive oxygen species
mitochondria dysfunction
acetylcholinesterase
Reducing iron in the brain: a novel pharmacologic mechanism of huperzine A in the treatment of Alzheimer's disease
期刊论文
NEUROBIOLOGY OF AGING, 2014, 卷号: 35, 期号: 5, 页码: 1045-1054
作者:
Huang, Xiao-Tian
;
Qian, Zhong-Ming
;
He, Xuan
;
Gong, Qi
;
Wu, Ka-Chun
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
Huperzine A
Alzheimer's disease
Brain iron
Transferrin receptor 1
Double transgenic APPswe/PS1dE9 mice (APP/PS mice)
The neuronal amyloid precursor protein (APP)
Phase I study on the pharmacokinetics and tolerance of ZT-1, a prodrug of huperzine A, for the treatment of Alzheimer's disease
期刊论文
ACTA PHARMACOLOGICA SINICA, 2013, 卷号: 34, 期号: 7, 页码: 976-982
作者:
Jia, Jing-ying
;
Zhao, Qian-hua
;
Liu, Yun
;
Gui, Yu-zhou
;
Liu, Gang-yi
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/01/08
ZT-1
huperzine A
prodrug
AChE inhibitor
drug tolerance
pharmacokinetics
Alzheimer's disease
Quantitative proteomic analysis reveals the neuroprotective effects of huperzine A for amyloid beta treated neuroblastoma N2a cells
期刊论文
PROTEOMICS, 2013, 卷号: 13, 期号: 8, 页码: 1314-1324
作者:
Tao, Yimin
;
Fang, Li
;
Yang, Yiming
;
Jiang, Hualiang
;
Yang, Huaiyu
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
Alzheimer's disease
Animal proteomics
LC-MS
MS
Huperzine A
p53
Determination of Huperzine A and Huperzine B in Huperzia serrata collected at diffefent collecting times by HPLC
期刊论文
China Journal of Traditional Chinese Medicine and Pharmacy, 2013, 卷号: 28, 期号: 2, 页码: 504-506
作者:
Zhou Xiaolei
;
Yuan Jingquan
;
Wang Shuo
;
Yan Zhigang
;
Feng Shixin
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2019/01/08
Huperzia serrata
Different season of harvesting
Huperzine A
Huperzine B
HPLC
phaseistudyonthepharmacokineticsandtoleranceofzt1aprodrugofhuperzineaforthetreatmentofalzheimersdisease
期刊论文
actapharmacologicasinica, 2013, 卷号: 34, 期号: 7, 页码: 976
作者:
Jia Jingying
;
Zhao Qianhua
;
Liu Yun
;
Gui Yuzhou
;
Liu Gangyi
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2020/07/01
CHOLINESTERASE INHIBITOR
CHOLINERGIC HYPOTHESIS
PROGRESS
RAT
MEDICINE
VITRO
DRUG
ZT-1
huperzine A
prodrug
AChE inhibitor
drug tolerance
pharmacokinetics
Alzheimer's disease
New insights into huperzine A for the treatment of Alzheimer's disease
期刊论文
ACTA PHARMACOLOGICA SINICA, 2012, 卷号: 33, 期号: 9, 页码: 1170-1175
作者:
Zhang, Hai-yan
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
Alzheimer's disease
huperzine A
acetylcholinesterase
mitochondrion
controlled release
Huperzine A Alleviates Synaptic Deficits and Modulates Amyloidogenic and Nonamyloidogenic Pathways in APPswe/PS1dE9 Transgenic Mice
期刊论文
JOURNAL OF NEUROSCIENCE RESEARCH, 2012, 卷号: 90, 期号: 2, 页码: 508-517
作者:
Wang, Ying
;
Tang, Xi Can
;
Zhang, Hai Yan
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
Alzheimer's disease
huperzine A
beta-amyloid
ADAM10
BACE1
Decreased Accumulation of Subcellular Amyloid-beta with Improved Mitochondrial Function Mediates the Neuroprotective Effect of Huperzine A
期刊论文
JOURNAL OF ALZHEIMERS DISEASE, 2012, 卷号: 31, 期号: 1, 页码: 131-142
作者:
Yang, Ling
;
Ye, Chun-yan
;
Huang, Xiao-tian
;
Tang, Xi-can
;
Zhang, Hai-yan
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/01/08
Alzheimer's disease
amyloid-beta peptide
huperzine A
mitochondrial dysfunction
oligomer
Simultaneous determination of huperzine A and huperzine B in different parts of Huperzia serrata from different habitats by HPLC
期刊论文
Chinese Journal of Pharmaceutical Analysis, 2012, 卷号: 32, 期号: 9, 页码: 1541
作者:
Yuan Jingquan
;
Zhou Xiaolei
;
Wang Shuo
;
Yan Zhigang
;
Feng Shixin
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2019/01/08
Huperzia serrata
Qiancengta
huperzine A
huperzine B
HPLC
composition analysis of root,leaf and stem
traditional Chinese medicine quality control
different habitats quality evaluation
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