New insights into huperzine A for the treatment of Alzheimer's disease

doi:10.1038/aps.2012.128

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第二研究室

	New insights into huperzine A for the treatment of Alzheimer's disease
	Zhang, Hai-yan
刊名	ACTA PHARMACOLOGICA SINICA
	2012-09
卷号	33 期号:9 页码:1170-1175
关键词	Alzheimer's disease huperzine A acetylcholinesterase mitochondrion controlled release
ISSN号	1671-4083
DOI	10.1038/aps.2012.128
文献子类	Article
英文摘要	Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). Accordingly, some new mechanisms of action for huperzine A have been discovered over the past decades. In addition to its AChE inhibitory effect, potent multifaceted neuroprotective effect through activating cholinergic system and directly acting on mitochondria have been explored. Moreover, in order to maximize the efficacy and safety of huperzine A therapy, great efforts have been made to optimize drug delivery system. In the present article, an attempt is made to discuss the current progress and future perspective for huperzine A therapy in AD.
资助项目	Ministry of Science and Technology of China[2011CB510004] ; National Natural Science Foundation of China[81173034] ; National Natural Science Foundation of China[81072646] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program" of China[2012ZX09301001001] ; SKLDR/SIMM Projects[SIM-M1105KF-04] ; Shanghai Science and Technology Development Funds, SA-SIBS Scholarship Program[10QA1408100]
WOS关键词	NERVE GROWTH-FACTOR ; AMYLOID PRECURSOR PROTEIN ; RAT CORTICAL-NEURONS ; ATTENUATES MITOCHONDRIAL DYSFUNCTION ; NICOTINIC ACETYLCHOLINE-RECEPTOR ; INDUCED OXIDATIVE INJURY ; A LOADED MICROSPHERES ; PC12 CELLS ; CEREBRAL-ISCHEMIA ; BETA-PEPTIDE
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
CSCD记录号	CSCD:4635868
出版者	ACTA PHARMACOLOGICA SINICA
WOS记录号	WOS:000308391000009
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277965]
专题	药理学第二研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Zhang, Hai-yan
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Hai-yan. New insights into huperzine A for the treatment of Alzheimer's disease[J]. ACTA PHARMACOLOGICA SINICA,2012,33(9):1170-1175.
APA	Zhang, Hai-yan.(2012).New insights into huperzine A for the treatment of Alzheimer's disease.ACTA PHARMACOLOGICA SINICA,33(9),1170-1175.
MLA	Zhang, Hai-yan."New insights into huperzine A for the treatment of Alzheimer's disease".ACTA PHARMACOLOGICA SINICA 33.9(2012):1170-1175.