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科研机构
上海药物研究所 [12]
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期刊论文 [12]
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2021 [1]
2018 [1]
2017 [1]
2015 [2]
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内容类型:期刊论文
专题:上海药物研究所
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Antibodies Against Pseudomonas aeruginosa Alkaline Protease Directly Enhance Disruption of Neutrophil Extracellular Traps Mediated by This Enzyme
期刊论文
FRONTIERS IN IMMUNOLOGY, 2021, 卷号: 12, 页码: 16
作者:
Jing, Chendi
;
Liu, Chenghua
;
Liu, Yu
;
Feng, Ruli
;
Cao, Run
收藏
  |  
浏览/下载:70/0
  |  
提交时间:2021/05/24
Pseudomonas aeruginosa
alkaline protease
alkaline protease inhibitor
neutrophil extracellular traps
antibody-dependent enhancement
Exploring molecular mechanism of allosteric inhibitor to relieve drug resistance of multiple mutations in HIV-1 protease by enhanced conformational sampling
期刊论文
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2018, 卷号: 86, 期号: 12, 页码: 1294-1305
作者:
Chen, Jianzhong
;
Peng, Cheng
;
Wang, Jinan
;
Zhu, Weiliang
收藏
  |  
浏览/下载:60/0
  |  
提交时间:2019/01/08
allosteric inhibitor
HIV-1 protease
MM-GBSA
normal mode analysis
REMD
The Second-generation of Highly Potent Hepatitis C Virus (HCV) NS3/4A Protease Inhibitors: Evolutionary Design Based on Tailor-made Amino Acids, Synthesis and Major Features of Bio-activity
期刊论文
CURRENT PHARMACEUTICAL DESIGN, 2017, 卷号: 23, 期号: 30, 页码: 4493-4554
作者:
Wang, Shuni
;
Wang, Yibing
;
Wang, Jiang
;
Sato, Tatsunori
;
Izawa, Kunisuke
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2019/01/08
Hepatitis C virus (HCV)
pandemic
direct-acting antiviral agents (DAAs)
NS3/4A protease inhibitor
tailor-made amino acids
structure-activity relationship (SAR)
asymmetric synthesis
ring-closing metathesis (RCM)
Enhancement of cellular uptake, transport and oral absorption of protease inhibitor saquinavir by nanocrystal formulation
期刊论文
ACTA PHARMACOLOGICA SINICA, 2015, 卷号: 36, 期号: 9, 页码: 1151-1160
作者:
He, Yuan
;
Xia, Deng-ning
;
Li, Qiu-xia
;
Tao, Jin-song
;
Gan, Yong
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
saquinavir
protease inhibitor
nanocrystals
Caco-2 cell monolayer
intestinal mucosa
pharmacokinetics
enhancementofcellularuptaketransportandoralabsorptionofproteaseinhibitorsaquinavirbynanocrystalformulation
期刊论文
actapharmacologicasinica, 2015, 卷号: 36, 期号: 9, 页码: 1151
作者:
He Yuan
;
Xia Dengning
;
Li Qiuxia
;
Tao Jinsong
;
Gan Yong
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2020/07/01
NITRENDIPINE NANOCRYSTALS
P-GLYCOPROTEIN
NANOPARTICLES
BIOAVAILABILITY
CELLS
STABILITY
DELIVERY
DRUGS
FATE
saquinavir
protease inhibitor
nanocrystals
Caco-2 cell monolayer
intestinal mucosa
pharmacokinetics
Application of a cell-based protease assay for testing inhibitors of picornavirus 3C proteases
期刊论文
ANTIVIRAL RESEARCH, 2014, 卷号: 103, 页码: 17-24
作者:
van der Linden, Lonneke
;
Ulferts, Rachel
;
Nabuurs, Sander B.
;
Kusov, Yuri
;
Liu, Hong
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/01/08
Cell-based assay
Protease
3C(pro)
Picornavirus
Inhibitor
improvedsynthesisofrupintrivir
期刊论文
sciencechinachemistry, 2012, 卷号: 55, 期号: 6, 页码: 1101
作者:
Lin Daizong
;
Qian Wangke
;
Hilgenfeld Rolf
;
Jiang Hualiang
;
Chen Kaixian
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2020/07/01
RHINOVIRUS PROTEASE INHIBITOR
STRUCTURE-BASED DESIGN
BIOLOGICAL EVALUATION
ENTEROVIRUS 71
INTERMEDIATE
PROTEINASE
EFFICIENT
AG7088
rupintrivir
AG7088
synthesis
Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease
期刊论文
ANTIVIRAL RESEARCH, 2011, 卷号: 92, 期号: 2, 页码: 204-212
作者:
Zhu, Lili
;
George, Shyla
;
Schmidt, Marco F.
;
Al-Gharabli, Samer I.
;
Rademann, Joerg
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/01/08
Aldehyde inhibitor
Antiviral drug design
Cysteine protease
Methionine-aspartic acid interaction
X-ray crystallography
Design and synthesis of cinanserin analogs as severe acute respiratory syndrome coronavirus 3CL protease inhibitors
期刊论文
CHEMICAL & PHARMACEUTICAL BULLETIN, 2008, 卷号: 56, 期号: 10, 页码: 1400-1405
作者:
Yang, Qiangang
;
Chen, Lill
;
He, Xuchang
;
Gao, Zhenting
;
Bai, Donglu
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
SARS coronavirus 3CL protease
cinanserin analogs
inhibitor
fluorescence resonance energy transfer-based assay
Synthesis and SAR studies on hyperin and its analogues as 3CL protease inhibitors of human coronavirus 229E
期刊论文
Chinese Journal of Medicinal Chemistry, 2007, 卷号: 17, 期号: 5, 页码: 288-294
作者:
JIA Qi
;
LI Jian
;
CHEN Lili
;
LIU Xiaofeng
;
TAN Hongsheng
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
hyperin
human coronavirus 229E
3CL protease inhibitor
SAR
surface plasmon resonance
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