improvedsynthesisofrupintrivir

doi:10.1007/s11426-011-4478-5

	improvedsynthesisofrupintrivir
	Lin Daizong 1; Qian Wangke 2; Hilgenfeld Rolf 1; Jiang Hualiang 1; Chen Kaixian 1; Liu Hong 1
刊名	sciencechinachemistry
	2012
卷号	55 期号:6 页码:1101
关键词	RHINOVIRUS PROTEASE INHIBITOR STRUCTURE-BASED DESIGN BIOLOGICAL EVALUATION ENTEROVIRUS 71 INTERMEDIATE PROTEINASE EFFICIENT AG7088 rupintrivir AG7088 synthesis
ISSN号	1674-7291
DOI	10.1007/s11426-011-4478-5
英文摘要	An improved synthesis of rupintrivir (AG7088) was accomplished using three amino acids (l-glutamic acid, d-4-fluorophenylalanine, and l-valine) as the building blocks. The key fragment ketomethylene dipeptide isostere was constructed with the valine derivative and phenylpropionic acid derivative, followed by coupling with a lactam derivative and an isoxazole acid chloride to provide AG7088 totally in eight steps.
资助项目	[National Natural Science Foundation of China] ; [National Basic Research Program of China] ; [Chinese Academy of Sciences] ; [European Commission]
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/284800]
专题	中国科学院上海药物研究所
作者单位	1.中国科学院上海药物研究所 2.沈阳药科大学
推荐引用方式 GB/T 7714	Lin Daizong,Qian Wangke,Hilgenfeld Rolf,et al. improvedsynthesisofrupintrivir[J]. sciencechinachemistry,2012,55(6):1101.
APA	Lin Daizong,Qian Wangke,Hilgenfeld Rolf,Jiang Hualiang,Chen Kaixian,&Liu Hong.(2012).improvedsynthesisofrupintrivir.sciencechinachemistry,55(6),1101.
MLA	Lin Daizong,et al."improvedsynthesisofrupintrivir".sciencechinachemistry 55.6(2012):1101.