Amyloid precursor protein  endothelial dysfunction  lung microcirculation  neuroinflammation  reactive nitrogen species  

nerve  regeneration  neurodegenerative  disease  Alzheimer’s  disease  RETINA  amyloid-β  β-site  amyloid  precursor  protein  cleaving  enzyme  APP/PS-1  transgenic  mouse  neural  regeneration  nerve regeneration neurodegenerative disease Alzheimer＇s disease retina amyloid-β β-site amyloid precursor protein cleaving enzyme 1 APP/PS-1 transgenic mouse neural regeneration  

Amyloid precursor protein  Alzheimer&apos  Yeast two-hybrid screening  Cell death  Pelizaeus-Merzbacher disease  PELIZAEUS-MERZBACHER DISEASE  APP-BINDING  SURFACE  FLRT3  CELL  OUTGROWTH  ADHESION  NEURONS  SYSTEM  FE65  s disease  

Chirality  Clausenamide  Dementia  Long-term potentiation  Signaling pathway  Calcium  6-OHDA  6-hydroxyldopamine  ACE  acetylcholinesterase  ACh  acetylcholine  AD  Alzheimer's disease  AUC0–12 h  0–12 h area under curve  APP  amyloid precursor protein  APV  R-2-amino-5-phosphonopentanoate  AUC0−∝  whole area under curve  BBB  blood–brain barrier  BDNF  brain-derived neurotrophic factor  CaM  calmodulin  CaMKII  calmodulin kinase II  ChAT  choline acetyltransferase  CREB  cAMP responding element binding  CHM  Chinese herbal medicine  clau  clausenamide  CL  clearance  Cmax  maximum concentration  CDK-5  cyclin-dependent kinase-5  DM  diabetes mellitus  DAG  diacylglycerol  ER  endoplasmic reticulum  ERK  extracellular signal-regulated kinases  GSK-3  glycogen synthase kinase-3  IP3  inositol triphosphate  LTP  long term potentiation  MWM  Morris water maze  NGF  nerve growth factor  NMDA  N-Methyl-D-aspartate  D  nNOS  neural nitric oxide synthase  PAT  passive avoidance tasks  Pir  piracetam  PLC  phospholipase C  PP1  phosphate 1  PKC  protein kinase C  tmax  time of peak concentration  t1/2α  absorption half-life  t1/2β  elimination half-life  Tau  microtubule-associated proteins  TCM  traditional Chinese medicine  Vd  apparent volume of distribution  VDCC  voltage-dependent calcium channel