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科研机构
上海药物研究所 [11]
内容类型
期刊论文 [11]
发表日期
2020 [6]
2018 [4]
2011 [1]
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Large-scale Generation of Functional and Transplantable Hepatocytes and Cholangiocytes from Human Endoderm Stem Cells
期刊论文
CELL REPORTS, 2020, 卷号: 33, 期号: 10, 页码: 24
作者:
Feng, Sisi
;
Wu, Jiaying
;
Qiu, Wei-Lin
;
Yang, Li
;
Deng, Xiaogang
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2021/05/24
DW14006 as a direct AMPK alpha 1 activator improves pathology of AD model mice by regulating microglial phagocytosis and neuroinflammation
期刊论文
BRAIN BEHAVIOR AND IMMUNITY, 2020, 卷号: 90, 页码: 55-69
作者:
Lv, Jianlu
;
Wang, Wei
;
Zhu, Xialin
;
Xu, Xiaoju
;
Yan, Qiuying
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/12/21
Alzheimer'sdisease
Microglia
AMPK alpha 1
DW14006
Phagocytosis
Neuro-inflammation
Antispasmodic Drug Drofenine as an Inhibitor of Kv2.1 Channel Ameliorates Peripheral Neuropathy in Diabetic Mice
期刊论文
ISCIENCE, 2020, 卷号: 23, 期号: 10, 页码: 56
作者:
Xu, Xiaoju
;
Xu, Xu
;
Hao, Yanping
;
Zhu, Xialin
;
Lu, Jian
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2021/05/24
DW14006 as a Direct AMPK alpha Activator Ameliorates Diabetic Peripheral Neuropathy in Mice
期刊论文
DIABETES, 2020, 卷号: 69, 期号: 9, 页码: 1974-1988
作者:
Xu, Xu
;
Wang, Wei
;
Wang, Zhengyu
;
Lv, Jianlu
;
Xu, Xiaoju
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/12/24
Discovery of nitazoxanide-based derivatives as autophagy activators for the treatment of Alzheimer's disease
期刊论文
ACTA PHARMACEUTICA SINICA B, 2020, 卷号: 10, 期号: 4, 页码: 646-666
作者:
Li, Xiaokang
;
Lu, Jian
;
Xu, Yixiang
;
Wang, Jiaying
;
Qiu, Xiaoxia
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2020/07/01
Alzheimer's disease
Autophagy
Nitazoxanide
beta-amyloid
Tau protein
Design, synthesis and biological evaluation of vincamine derivatives as potential pancreatic beta-cells protective agents for the treatment of type 2 diabetes mellitus
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 188, 页码: 17
作者:
Wang, Junwei
;
Lv, Xue
;
Xu, Jiawen
;
Liu, Xinpeng
;
Du, Te
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2020/07/01
Type 2 diabetes mellitus
Pancreatic beta-cells protective agents
Vincamine derivatives
Structural modifications
Structure-activity relationships
A preclinical overview of metformin for the treatment of type 2 diabetes
期刊论文
BIOMEDICINE & PHARMACOTHERAPY, 2018, 卷号: 106, 页码: 1227-1235
作者:
Zhou, Tingting
;
Xu, Xin
;
Du, Mengfan
;
Zhao, Tong
;
Wang, Jiaying
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2019/01/08
Gluconeogenesis
Insulin sensitivity
Mechanism
Metformin
Type 2 diabetes (T2D)
HS218 as an FXR antagonist suppresses gluconeogenesis by inhibiting FXR binding to PGC-1α promoter
期刊论文
Metabolism: clinical and experimental, 2018, 卷号: 85, 页码: 126-138
作者:
Xu, Xin
;
Shi, Xiaofan
;
Chen, Yidi
;
Zhou, Tingting
;
Wang, Jiaying
收藏
  |  
浏览/下载:69/0
  |  
提交时间:2019/01/08
HS218 as an FXR antagonist suppresses gluconeogenesis by inhibiting FXR binding to PGC-1 alpha promoter
期刊论文
METABOLISM-CLINICAL AND EXPERIMENTAL, 2018, 卷号: 85, 页码: 126-138
作者:
Xu, Xin
;
Shi, Xiaofan
;
Chen, Yidi
;
Zhou, Tingting
;
Wang, Jiaying
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2020/07/01
T2DM
Gluconeogenesis
FXR antagonist
PGC-1 alpha
Drug lead compound
Protopanaxadiol derivative DDPU improves behavior and cognitive deficit in AD mice involving regulation of both ER stress and autophagy
期刊论文
NEUROPHARMACOLOGY, 2018, 卷号: 130, 页码: 77-91
作者:
Guo, Xiaodan
;
Lv, Jianlu
;
Lu, Jian
;
Fan, Lei
;
Huang, Xi
收藏
  |  
浏览/下载:54/0
  |  
提交时间:2019/01/08
Alzheimer's disease
Ginseng
Autophagy
BACE1
ER stress
Amyloid beta
Apoptosis
APP/PS1 transgenic mice
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