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科研机构
上海药物研究所 [8]
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期刊论文 [8]
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2021 [1]
2018 [1]
2017 [2]
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A 36-week multicenter, randomized, double-blind, placebo-controlled, parallel-group, phase 3 clinical trial of sodium oligomannate for mild-to-moderate Alzheimer’s dementia
期刊论文
Alzheimer's Research & Therapy, 2021, 卷号: 13, 期号: 1
作者:
Xiao,Shifu
;
Chan,Piu
;
Wang,Tao
;
Hong,Zhen
;
Wang,Shuzhen
收藏
  |  
浏览/下载:157/0
  |  
提交时间:2021/05/24
Sodium oligomannate
Efficacy
Safety
Alzheimer’s disease
Clinical trial
Identification and Characterizations of Novel, Selective Histone Methyltransferase SET7 Inhibitors by Scaffold Hopping- and 2D-Molecular Fingerprint-Based Similarity Search
期刊论文
MOLECULES, 2018, 卷号: 23, 期号: 3
作者:
Ding, Hong
;
Lu, Wen Chao
;
Hu, Jun Chi
;
Liu, Yu-Chih
;
Zhang, Chen Hua
收藏
  |  
浏览/下载:53/0
  |  
提交时间:2019/01/08
SET7
inhibitor
similarity search
ligand-based drug design
chemical biology probe
Identification of mitoxantrone as a new inhibitor of ROS1 fusion protein in non-small cell lung cancer cells
期刊论文
MEDCHEMCOMM, 2017, 卷号: 8, 期号: 3, 页码: 621-624
作者:
Luo, Lian-Xiang
;
Fan, Xing-Xing
;
Li, Ying
;
Peng, Xia
;
Ji, Yin-Chun
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
Novel PARP1/2 inhibitor mefuparib hydrochloride elicits potent in vitro and in vivo anticancer activity, characteristic of high tissue distribution
期刊论文
ONCOTARGET, 2017, 卷号: 8, 期号: 3, 页码: 4156-4168
作者:
He, Jin-Xue
;
Wang, Meng
;
Huan, Xia-Juan
;
Chen, Chuan-Huizi
;
Song, Shan-Shan
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2019/01/08
MPH
PARP inhibitor
homologous recombination
antitumor activity
synthetic lethality
NMR-based platform for fragment-based lead discovery used in screening BRD4-targeted compounds
期刊论文
ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 7, 页码: 984-993
作者:
Yu, Jun-lan
;
Chen, Tian-tian
;
Zhou, Chen
;
Lian, Fu-lin
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/01/08
fragment-based lead discovery
NMR
bromodomain
BRD4 inhibitors
Cordyceps sinensis protects against liver and heart injuries in a rat model of chronic kidney disease: a metabolomic analysis
期刊论文
ACTA PHARMACOLOGICA SINICA, 2014, 卷号: 35, 期号: 5, 页码: 697-706
作者:
Liu, Xia
;
Zhong, Fang
;
Tang, Xu-long
;
Lian, Fu-lin
;
Zhou, Qiao
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
Cordyceps sinensis
chronic kidney disease
liver injury
heart injury
metabolomics
nuclear magnetic resonance
traditional Chinese medicine
H-1-NMR-based metabonomic analysis of metabolic profiling in diabetic nephropathy rats induced by streptozotocin
期刊论文
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2011, 卷号: 300, 期号: 4, 页码: F947-F956
作者:
Zhao, Liangcai
;
Gao, Hongchang
;
Lian, Fulin
;
Liu, Xia
;
Zhao, Yongxiang
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/01/08
nuclear magnetic resonance
metabonomics
pathogenic process
energy metabolism
Quantitative determination of 14 major constituents in the herbal preparation Luan-Pao-Prescription using HPLC coupled with photodiode array detection
期刊论文
CHROMATOGRAPHIA, 2007, 卷号: 66, 期号: 3-4, 页码: 267-270
作者:
Zhang, Jin-qiang
;
Wang, Xiao-ming
;
Lu, Zhi-qiang
;
Huang, Hui-lian
;
Chen, Guang-tong
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
column liquid chromatography
Luan-pao-prescription
quality control
traditional Chinese medicine
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