Cordyceps sinensis protects against liver and heart injuries in a rat model of chronic kidney disease: a metabolomic analysis

doi:10.1038/aps.2013.186

	Cordyceps sinensis protects against liver and heart injuries in a rat model of chronic kidney disease: a metabolomic analysis
	Liu, Xia2 ; Zhong, Fang 1; Tang, Xu-long 2; Lian, Fu-lin 2; Zhou, Qiao 1; Guo, Shan-mai 1; Liu, Jia-fu 3; Sun, Peng 2; Hao, Xu 1; Lu, Ying 1
刊名	ACTA PHARMACOLOGICA SINICA
	2014-05
卷号	35 期号:5 页码:697-706
关键词	Cordyceps sinensis chronic kidney disease liver injury heart injury metabolomics nuclear magnetic resonance traditional Chinese medicine
ISSN号	1671-4083
DOI	10.1038/aps.2013.186
文献子类	Article
英文摘要	Aim: To test the hypothesis that the traditional Chinese medicine Cordyceps sinensis could improve the metabolic function of extrarenal organs to achieve its anti-chronic kidney disease (CKD) effects. Methods: Male SD rats were divided into CKD rats (with 5/6-nephrectomy), CKD rats treated with Cordyceps sinensis (4 mg.kg(-1).d(-1), po), and sham-operated rats. After an 8-week treatment, metabolites were extracted from the hearts and livers of the rats, and then subjected to H-1-NMR-based metabolomic analysis. Results: Oxidative stress, energy metabolism, amino acid and protein metabolism and choline metabolism were considered as links between CKD and extrarenal organ dysfunction. Within the experimental period of 8 weeks, the metabolic disorders in the liver were more pronounced than in the heart, suggesting that CKD-related extrarenal organ dysfunctions occurred sequentially rather than simultaneously. Oral administration of Cordyceps sinensis exerted statistically significant rescue effects on the liver and heart by reversely regulating levels of those metabolites that are typically perturbed in CKD. Conclusion: Oral administration of Cordyceps sinensis significantly attenuates the liver and heart injuries in CKD rats. The H-1 NMR-based metabolomic approach has provided a systematic view for understanding of CKD and the drug treatment, which can also be used to elucidate the mechanisms of action of other traditional Chinese medicines.
资助项目	National Natural Science Foundation of China[30900662] ; Shanghai Foundation for Development of Science and Technology[08411965600] ; "100 Talents Program" of the Chinese Academy of Sciences[00000000]
WOS关键词	CHRONIC-RENAL-FAILURE ; UPLC Q-TOF/HSMS/MSE ; OXIDATIVE STRESS ; URINARY METABONOMICS ; H-1-NMR SPECTROSCOPY ; HEPATIC GLUTATHIONE ; PORIA-COCOS ; Q-TOF/MS ; TAURINE ; TISSUE
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
CSCD记录号	CSCD:5142660
出版者	ACTA PHARMACOLOGICA SINICA
WOS记录号	WOS:000335447000014
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277102]
专题	分析化学研究室药物安全性评价中心
通讯作者	Wang, Wei-ming
作者单位	1.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Nephrol, Shanghai 200025, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Analyt Chem, Shanghai 201203, Peoples R China; 3.Blood Ctr Wisconsin, Blood Res Inst, Milwaukee, WI 53226 USA
推荐引用方式 GB/T 7714	Liu, Xia,Zhong, Fang,Tang, Xu-long,et al. Cordyceps sinensis protects against liver and heart injuries in a rat model of chronic kidney disease: a metabolomic analysis[J]. ACTA PHARMACOLOGICA SINICA,2014,35(5):697-706.
APA	Liu, Xia.,Zhong, Fang.,Tang, Xu-long.,Lian, Fu-lin.,Zhou, Qiao.,...&Zhang, Nai-xia.(2014).Cordyceps sinensis protects against liver and heart injuries in a rat model of chronic kidney disease: a metabolomic analysis.ACTA PHARMACOLOGICA SINICA,35(5),697-706.
MLA	Liu, Xia,et al."Cordyceps sinensis protects against liver and heart injuries in a rat model of chronic kidney disease: a metabolomic analysis".ACTA PHARMACOLOGICA SINICA 35.5(2014):697-706.