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浏览/检索结果: 共9条，第1-9条 帮助 限定条件 专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 DW14006 as a direct AMPK alpha 1 activator improves pathology of AD model mice by regulating microglial phagocytosis and neuroinflammation 期刊论文 BRAIN BEHAVIOR AND IMMUNITY, 2020, 卷号: 90, 页码: 55-69 作者:  Lv, Jianlu;  Wang, Wei;  Zhu, Xialin;  Xu, Xiaoju;  Yan, Qiuying 收藏  |  浏览/下载：33/0  |  提交时间：2020/12/21 Alzheimer'sdisease  Microglia  AMPK alpha 1  DW14006  Phagocytosis  Neuro-inflammation   Vincamine as a GPR40 agonist improves glucose homeostasis in type 2 diabetic mice 期刊论文 JOURNAL OF ENDOCRINOLOGY, 2019, 卷号: 240, 期号: 2, 页码: 195-214 作者:  Du, Te;  Yang, Liu;  Xu, Xu;  Shi, Xiaofan;  Xu, Xin 收藏  |  浏览/下载：105/0  |  提交时间：2019/01/08 vincamine  GPR40  beta-cell function  insulin secretion  type 2 diabetes   HS218 as an FXR antagonist suppresses gluconeogenesis by inhibiting FXR binding to PGC-1α promoter 期刊论文 Metabolism: clinical and experimental, 2018, 卷号: 85, 页码: 126-138 作者:  Xu, Xin;  Shi, Xiaofan;  Chen, Yidi;  Zhou, Tingting;  Wang, Jiaying 收藏  |  浏览/下载：73/0  |  提交时间：2019/01/08 HS218 as an FXR antagonist suppresses gluconeogenesis by inhibiting FXR binding to PGC-1 alpha promoter 期刊论文 METABOLISM-CLINICAL AND EXPERIMENTAL, 2018, 卷号: 85, 页码: 126-138 作者:  Xu, Xin;  Shi, Xiaofan;  Chen, Yidi;  Zhou, Tingting;  Wang, Jiaying 收藏  |  浏览/下载：5/0  |  提交时间：2020/07/01 T2DM  Gluconeogenesis  FXR antagonist  PGC-1 alpha  Drug lead compound   TSPA as a novel ATF6 alpha translocation inducer efficiently ameliorates insulin sensitivity restoration and glucose homeostasis in db/db mice 期刊论文 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 卷号: 499, 期号: 4, 页码: 948-953 作者:  Zhou, Tingting;  Cheng, Yanhua;  Yan, Wenzhong;  Shi, Xiaofan;  Xu, Xin 收藏  |  浏览/下载：35/0  |  提交时间：2019/01/08 ATF6 alpha  ER stress  insulin resistance  TSPA  T2DM   Discovery of cycloalkyl-fused N-thiazol-2-yl-benzamides as tissue non-specific glucokinase activators: Design, synthesis, and biological evaluation 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 139, 页码: 128-152 作者:  Wang, Zhengyu;  Shi, Xiaofan;  Zhang, Huan;  Yu, Liang;  Cheng, Yanhua 收藏  |  浏览/下载：35/0  |  提交时间：2019/01/08 Type 2 diabetes mellitus  Hypoglycemia  Dyslipidemia  Glucokinase activators  N-Thiazol-2-yl-benzamides   thamnoliavermicularisextractimproveslearningabilityinappps1transgenicmicebyamelioratingbothaandtaupathologies 期刊论文 actapharmacologicasinica, 2017, 卷号: 38, 期号: 1, 页码: 9 作者:  Li Cong;  Guo Xiaodan;  Lei Min;  Wu Jiayi;  Jin Jiazhen 收藏  |  浏览/下载：7/0  |  提交时间：2020/07/01 Alzheimer's disease  Thamnolia vermicularis  SH-SY5Y cells  APP/PS1 transgenic mice  senile plaque  cognition  amyloid-β  Tau  autophagy  BACE1  GSK3β  PI_3K   Thamnolia vermicularis extract improves learning ability in APP/PS1 transgenic mice by ameliorating both Aβ and Tau pathologies 期刊论文 Acta Pharmacologica Sinica, 2017, 卷号: 38, 期号: 1, 页码: 9 作者:  Li Cong;  Guo Xiaodan;  Lei Min;  Wu Jiayi;  Jin Jiazhen 收藏  |  浏览/下载：6/0  |  提交时间：2020/12/24 Alzheimer's disease  Thamnolia vermicularis  SH-SY5Y cells  APP/PS1 transgenic mice  senile plaque  cognition  amyloid-β  Tau  autophagy  BACE1  GSK3β  PI_3K   beta-Resorcylic macrolide and octahydronaphthalene derivatives from a seagrass-derived fungus Fusarium sp PSU-ES123 期刊论文 TETRAHEDRON, 2016, 卷号: 72, 期号: 41, 页码: 6421-6427 作者:  Saetang, Praphatsorn;  Rukachaisirikul, Vatcharin;  Phongpaichit, Souwalak;  Sakayaroj, Jariya;  Shi, Xiaofan 收藏  |  浏览/下载：16/0  |  提交时间：2019/01/08 beta-Resorcylic macrolide  Octahydronaphthalene derivative  Antifungal activity  Cytotoxic activity  Protection of pancreatic beta-cells