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浏览/检索结果: 共39条，第1-10条 帮助 限定条件 发表日期：2021    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Theoretical study and application of 2-phenyl-1,3,4-thiadiazole derivatives with optical and inhibitory activity against SHP1 期刊论文 PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2021, 页码: 14 作者:  Zhang, Chun;  Sun, Yi-Tao;  Gao, Li-Xin;  Feng, Bo;  Yan, Xue 收藏  |  浏览/下载：21/0  |  提交时间：2022/01/18 Sublyratins A-O, Labdane-Type Diterpenoids from Croton sublyratus 期刊论文 JOURNAL OF NATURAL PRODUCTS, 2021, 卷号: 84, 期号: 11, 页码: 2971-2980 作者:  Qi, Jing-Jing;  Zhou, Jun-Su;  Zhang, Yan;  Fan, Yao-Yue;  Zhou, Bin 收藏  |  浏览/下载：19/0  |  提交时间：2022/01/18 Cryo-EM structures of PI3K alpha reveal conformational changes during inhibition and activation 期刊论文 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 卷号: 118, 期号: 45, 页码: 9 作者:  Liu, Xiao;  Yang, Su;  Hart, Jonathan R.;  Xu, Yingna;  Zou, Xinyu 收藏  |  浏览/下载：41/0  |  提交时间：2022/01/04 phosphoinositide 3-kinase (PI3K)  activation  inhibition  activity-dependent conformational changes   SNX10-mediated LPS sensing causes intestinal barrier dysfunction via a caspase-5-dependent signaling cascade 期刊论文 EMBO JOURNAL, 2021, 页码: 16 作者:  Wang, Xu;  Ni, Jiahui;  You, Yan;  Feng, Guize;  Zhang, Sulin 收藏  |  浏览/下载：38/0  |  提交时间：2021/12/16 E-cadherin  IBD  intestinal barrier function  LPS release  SNX10   Discovery and structure - activity relationship exploration of pyrazolo [1,5-a]pyrimidine derivatives as potent FLT3-ITD inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 48, 页码: 13 作者:  Chen, Yun;  Bai, Gang;  Li, Yan;  Ning, Yi;  Cao, Sufen 收藏  |  浏览/下载：32/0  |  提交时间：2021/12/01 FLT3  FLT3-ITD  Acute myeloid leukemia  Structure-activity relationships  Pyrazolo[1, 5-a]pyrimidine   Picomolar antimalarial agent from a Chinese medicinal plant 期刊论文 SCIENCE CHINA-CHEMISTRY, 2021, 页码: 5 作者:  Zhou, Bin;  Zimbres, Flavia M.;  Butler, Joshua H.;  Xu, Cheng-Hui;  Haney, Reagan S. 收藏  |  浏览/下载：62/0  |  提交时间：2021/12/01 medicinal plants  dimeric sesquiterpenoids  antimalarial agent  structure-activity relationship   Synthesis and bioactivity studies of covalent inhibitors derived from (-)-Chaetominine 期刊论文 JOURNAL OF MOLECULAR STRUCTURE, 2021, 卷号: 1241, 页码: 14 作者:  Zhou, Xian;  Feng, Xuexin;  Wang, Dachi;  Chen, Deheng;  Wu, Gaoxing 收藏  |  浏览/下载：86/0  |  提交时间：2021/08/17 Chaetominine  Cellular growth inhibition  Cancer cell line  Covalent warhead   Constitutive signal bias mediated by the human GHRHR splice variant 1 期刊论文 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 卷号: 118, 期号: 40, 页码: 10 作者:  Cong, Zhaotong;  Zhou, Fulai;  Zhang, Chao;  Zou, Xinyu;  Zhang, Huibing 收藏  |  浏览/下载：27/0  |  提交时间：2021/12/01 class B1 GPCR  receptor bias  cancer  cell proliferation   A validated HPLC-MS/MS method for determination of simmitecan and its metabolite chimmitecan in human plasma and its application to a pharmacokinetic study in Chinese patients with advanced solid tumor 期刊论文 JOURNAL OF SEPARATION SCIENCE, 2021, 页码: 8 作者:  Zhou, Jun;  Zhan, Yan;  Zhong, Dafang;  Chen, Xiaoyan;  Zhang, Yifan 收藏  |  浏览/下载：74/0  |  提交时间：2021/11/04 chimmitecan  mass spectrometry  pharmacokinetics  simmitecan  solid tumors   Structural mechanism of calcium-mediated hormone recognition and G beta interaction by the human melanocortin-1 receptor 期刊论文 CELL RESEARCH, 2021, 页码: 11 作者:  Ma, Shanshan;  Chen, Yan;  Dai, Antao;  Yin, Wanchao;  Guo, Jia 收藏  |  浏览/下载：24/0  |  提交时间：2021/11/04