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科研机构
上海药物研究所 [10]
内容类型
期刊论文 [10]
发表日期
2021 [10]
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发表日期:2021
专题:上海药物研究所
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Acceptor engineering of small-molecule fluorophores for NIR-II fluorescence and photoacoustic imaging
期刊论文
JOURNAL OF MATERIALS CHEMISTRY B, 2021, 卷号: 9, 期号: 48, 页码: 9951-9960
作者:
Li, Yaxi
;
Zhou, Hongli
;
Bi, Renzhe
;
Li, Xiuting
;
Zha, Menglei
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2022/01/04
Identification of phosphodiesterase-4 as the therapeutic target of arctigenin in alleviating psoriatic skin inflammation
期刊论文
JOURNAL OF ADVANCED RESEARCH, 2021, 卷号: 33, 页码: 241-251
作者:
Li, Heng
;
Zhang, Xianglei
;
Xiang, Caigui
;
Feng, Chunlan
;
Fan, Chen
收藏
  |  
浏览/下载:88/0
  |  
提交时间:2021/11/04
PDE4
Arctigenin
Psoriasis
Inflammation
Unusual polyoxygenated casbane diterpenoids from the South China Sea soft coral Sinularia erecta
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 114, 页码: 8
作者:
Liu, Jiao
;
Wu, Meng-Jun
;
Li, Heng
;
Wang, Hong
;
Tang, Wei
收藏
  |  
浏览/下载:66/0
  |  
提交时间:2021/11/04
Soft coral
Sinularia erecta
Casbane
Stereochemistry
Anti-inflammatory activity
Sinueretone A, a Diterpenoid with Unprecedented Tricyclo[12.1.0.0(5,9)] pentadecane Carbon Scaffold from the South China Sea Soft Coral Sinularia erecta
期刊论文
JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 86, 期号: 16, 页码: 10975-10981
作者:
Liu, Jiao
;
Li, Heng
;
Wu, Meng-Jun
;
Tang, Wei
;
Wang, Jian-Rong
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2021/11/04
Blockade of TLRs-triggered macrophage activation by caffeic acid exerted protective effects on experimental ulcerative colitis
期刊论文
CELLULAR IMMUNOLOGY, 2021, 卷号: 365, 页码: 10
作者:
Xiang, Caigui
;
Liu, Moting
;
Lu, Qiukai
;
Fan, Chen
;
Lu, Huimin
收藏
  |  
浏览/下载:60/0
  |  
提交时间:2021/08/17
Ulcerative colitis
Caffeic acid
Toll-like receptors
Macrophages
Diversity-oriented synthesis of cembranoid derivatives as potential anti-inflammatory agents
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 111, 页码: 8
作者:
Zhang, Cong
;
Li, Heng
;
Liu, Jin
;
Liu, Moting
;
Zhang, Hao
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2021/08/17
Marine natural product
Cembranoid
Anti-inflammation
molecular docking
structuremodification
Structure Activity Relationship
Discovery of a novel, potent and selective small-molecule inhibitor of PD-1/PD-L1 interaction with robust in vivo anti-tumour efficacy
期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2021, 页码: 20
作者:
Liu, Chenglong
;
Zhou, Feilong
;
Yan, Ziqin
;
Shen, Lian
;
Zhang, Xichen
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2021/06/11
immunotherapy
PD-1/PD-L1
TGF-beta
tumour immune microenvironment
Aristolochic acid I promoted clonal expansion but did not induce hepatocellular carcinoma in adult rats
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 12
作者:
Liu, Yong-zhen
;
Lu, Heng-lei
;
Qi, Xin-ming
;
Xing, Guo-zhen
;
Wang, Xin
收藏
  |  
浏览/下载:72/0
  |  
提交时间:2021/05/24
aristolochic acid I
glutathione S-transferase placental form-positive foci
clonal expansion
hepatocellular carcinoma
medium-term rat liver bioassay
DNA adducts
Structural insights into the human D1 and D2 dopamine receptor signaling complexes
期刊论文
CELL, 2021, 卷号: 184, 期号: 4, 页码: 931-+
作者:
Zhuang, Youwen
;
Xu, Peiyu
;
Mao, Chunyou
;
Wang, Lei
;
Krumm, Brian
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/05/24
Design, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 211, 页码: 20
作者:
Zhang, Rui
;
Li, Heng
;
Zhang, Xianglei
;
Li, Jian
;
Su, Haixia
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2021/05/24
PDE4 inhibitors
Tetrahydroisoquinoline
Antipsoriasis
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