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浏览/检索结果: 共10条，第1-10条 帮助 限定条件 发表日期：2020    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Development of Bisindole-Substituted Aminopyrazoles as Novel GSK-3 beta Inhibitors with Suppressive Effects against Microglial Inflammation and Oxidative Neurotoxicity 期刊论文 ACS CHEMICAL NEUROSCIENCE, 2020, 卷号: 11, 期号: 20, 页码: 3398-3408 作者:  Liu, Jian-Guo;  Zhao, Danfeng;  Gong, Qi;  Bao, Fengxia;  Chen, Wen-Wen 收藏  |  浏览/下载：16/0  |  提交时间：2021/05/24 Glycogen synthase kinase-3  bisindole-substituted aminopyrazoles  Alzheimer's disease  oxidative neurotoxicity  microglial inflammation   An exosome-like programmable-bioactivating paclitaxel prodrug nanoplatform for enhanced breast cancer metastasis inhibition 期刊论文 BIOMATERIALS, 2020, 卷号: 257, 页码: 13 作者:  Wang, Kaiyuan;  Ye, Hao;  Zhang, Xuanbo;  Wang, Xia;  Yang, Bin 收藏  |  浏览/下载：43/0  |  提交时间：2020/12/24 Exosome membrane  Cucurbitacin B  Paclitaxel  Breast cancer metastasis  Programmable bioactivation   SAF-189s, a potent new-generation ROS1 inhibitor, is active against crizotinib-resistant ROS1 mutant-driven tumors 期刊论文 ACTA PHARMACOLOGICA SINICA, 2020, 页码: 7 作者:  Xia, Zong-jun;  Ji, Yin-chun;  Sun, De-qiao;  Peng, Xia;  Gao, Ying-lei 收藏  |  浏览/下载：78/0  |  提交时间：2020/12/21 ROS1 kinase  ROS1 inhibitor  SAF-189s  lorlatinib  crizotinib resistance  G2032R mutant  NSCLC   GPR91, a critical signaling mechanism in modulating pathophysiologic processes in chronic illnesses 期刊论文 FASEB JOURNAL, 2020, 页码: 15 作者:  Li, Xinyi;  Xie, Li;  Qu, Xiangli;  Zhao, Bangyi;  Fu, Wei 收藏  |  浏览/下载：26/0  |  提交时间：2020/12/24 G protein-coupled receptor  innate immunity  metabolic regulation  succinate  SUCNR1   Identification and characterization of isocitrate dehydrogenase 1 (IDH1) as a functional target of marine natural product grincamycin B 期刊论文 ACTA PHARMACOLOGICA SINICA, 2020, 页码: 13 作者:  Wang, Zheng;  Li, Zeng-xia;  Zhao, Wen-cao;  Huang, Hong-bo;  Wang, Jia-qi 收藏  |  浏览/下载：83/0  |  提交时间：2020/12/24 grincamycin B  marine natural product  isocitrate dehydrogenase 1  apoptosis  ER stress  intracellular ROS  Zebrafish embryos  hematological malignancies   Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients 期刊论文 ACTA PHARMACOLOGICA SINICA, 2020, 页码: 11 作者:  Su, Hai-xia;  Yao, Sheng;  Zhao, Wen-feng;  Li, Min-jun;  Liu, Jia 收藏  |  浏览/下载：115/0  |  提交时间：2020/12/24 SARS-CoV-2  3CL protease  traditional Chinese medicines  Shuanghuanglian oral liquid  baicalin  baicalein   Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease 期刊论文 SCIENCE, 2020, 卷号: 368, 期号: 6497, 页码: 1331-+ 作者:  Dai, Wenhao;  Zhang, Bing;  Jiang, Xia-Ming;  Su, Haixia;  Li, Jian 收藏  |  浏览/下载：30/0  |  提交时间：2020/12/24 Repurposing antimycotic ciclopirox olamine as a promising anti-ischemic stroke agent 期刊论文 ACTA PHARMACEUTICA SINICA B, 2020, 卷号: 10, 期号: 3, 页码: 434-446 作者:  Feng, Hongxuan;  Hu, Linghao;  Zhu, Hongwen;  Tao, Lingxue;  Wu, Lei 收藏  |  浏览/下载：28/0  |  提交时间：2020/07/01 Blood-brain barrier  Brain ischemia  Cell cycle  Inflammation  Neuroprotection   Structural basis of ligand recognition and self-activation of orphan GPR52 期刊论文 NATURE, 2020, 页码: 21 作者:  Lin, Xi;  Li, Mingyue;  Wang, Niandong;  Wu, Yiran;  Luo, Zhipu 收藏  |  浏览/下载：178/0  |  提交时间：2020/07/01 Development of Novel N-hydroxypyridone Derivatives as Potential Anti-Ischemic Stroke Agents 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 3, 页码: 1051-1067 作者:  Hu, Linghao;  Feng, Hongxuan;  Zhang, Hongguang;  Yu, Songda;  Zhao, Qinyuan 收藏  |  浏览/下载：30/0  |  提交时间：2020/07/01