GPR91, a critical signaling mechanism in modulating pathophysiologic processes in chronic illnesses

doi:10.1096/fj.202001037R

	GPR91, a critical signaling mechanism in modulating pathophysiologic processes in chronic illnesses
	Li, Xinyi 2; Xie, Li 2; Qu, Xiangli 1,6; Zhao, Bangyi 3; Fu, Wei 3; Wu, Beili 1,6; Wu, Jian 2,4,5
刊名	FASEB JOURNAL
	2020-08-19
页码	15
关键词	G protein-coupled receptor innate immunity metabolic regulation succinate SUCNR1
ISSN号	0892-6638
DOI	10.1096/fj.202001037R
通讯作者	Wu, Beili(beiliwu@simm.ac.cn) ; Wu, Jian(jian.wu@fudan.edu.cn)
英文摘要	Succinate receptor GPR91 is one of G protein-coupled receptors (GPCRs), and is expressed in a variety of cell types and tissues. Succinate is its natural ligand, and its activation represents that an intrinsic metabolic intermediate exerts a regulatory role on many critical life processes involving pathophysiologic mechanisms, such as innate immunity, inflammation, tissue repair, and oncogenesis. With the illustration of 3-dimensional crystal structure of the receptor and discovery of its antagonists, it is possible to dissect the succinate-GPR91-G protein signaling pathways in different cell types under pathophysiological conditions. Deep understanding of the GPR91-ligand binding mode with various agonists and antagonists would aid in elucidating the molecular basis of a spectrum of chronic illnesses, such as hypertension, diabetes, and their renal and retina complications, metabolic-associated fatty liver diseases, such as nonalcoholic steatohepatitis and its fibrotic progression, inflammatory bowel diseases (Crohn's disease and ulcerative colitis), age-related macular degeneration, rheumatoid arthritis, and progressive behaviors of malignancies. With better delineation of critical regulatory role of the succinate-GPR91 axis in these illnesses, therapeutic intervention may be developed by specifically targeting this signaling pathway with small molecular antagonists or other strategies.
资助项目	National Natural Science Foundation of China[81572356] ; National Natural Science Foundation of China[81871997] ; National Natural Science Foundation of China[31825010] ; National Key R&D Program of China[2016YFE0107400] ; Shanghai Commission of Science and Technology[16140903700]
WOS关键词	SUCCINATE RECEPTOR GPR91 ; PROTEIN-COUPLED RECEPTORS ; CELLS ; ACTIVATION ; DISCOVERY ; LEADS ; GPCRS ; DYSFUNCTION ; NANOBODIES ; FUMARATE
WOS研究方向	Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology
语种	英语
出版者	WILEY
WOS记录号	WOS:000567542800001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/291589]
专题	中国科学院上海药物研究所
通讯作者	Wu, Beili; Wu, Jian
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, 555 Zhuchongzhi Rd, Shanghai 201203, Peoples R China 2.Fudan Univ, Sch Basic Med Sci, MOE NHC CAMS Key Lab Med Mol Virol, Dept Med Microbiol, Shanghai, Peoples R China 3.Fudan Univ, Sch Pharm, Dept Med Chem, Shanghai, Peoples R China 4.Fudan Univ, Zhongshan Hosp, Dept Gastroenterol & Hepatol, Shanghai, Peoples R China 5.Fudan Univ, Shanghai Med Coll, Shanghai Inst Liver Dis, Shanghai, Peoples R China 6.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Li, Xinyi,Xie, Li,Qu, Xiangli,et al. GPR91, a critical signaling mechanism in modulating pathophysiologic processes in chronic illnesses[J]. FASEB JOURNAL,2020:15.
APA	Li, Xinyi.,Xie, Li.,Qu, Xiangli.,Zhao, Bangyi.,Fu, Wei.,...&Wu, Jian.(2020).GPR91, a critical signaling mechanism in modulating pathophysiologic processes in chronic illnesses.FASEB JOURNAL,15.
MLA	Li, Xinyi,et al."GPR91, a critical signaling mechanism in modulating pathophysiologic processes in chronic illnesses".FASEB JOURNAL (2020):15.