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浏览/检索结果: 共10条，第1-10条 帮助 限定条件 发表日期：2019    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Small molecule IVQ, as a prodrug of gluconeogenesis inhibitor QVO, efficiently ameliorates glucose homeostasis in type 2 diabetic mice 期刊论文 ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 9, 页码: 1193-1204 作者:  Zhou, Ting-ting;  Zhao, Tong;  Ma, Fei;  Zhang, Yi-nan;  Jiang, Jing 收藏  |  浏览/下载：27/0  |  提交时间：2020/07/01 type 2 diabetes mellitus  hepatic gluconeogenesis  AMPK signaling pathway  (E)-3-(2-(quinoline-4-yl)vinyl)-1H-indol-6-ol (QVO)  4-[2-(1H-indol-3-yl)vinyl]quinoline (IVQ)  prodrug   Cinerols, Nitrogenous Meroterpenoids from the Marine Sponge Dysidea cinerea 期刊论文 JOURNAL OF NATURAL PRODUCTS, 2019, 卷号: 82, 期号: 9, 页码: 2586-2593 作者:  Jiao, Wei-Hua;  Li, Jing;  Wang, Dan;  Zhang, Meng-Meng;  Liu, Li-Yun 收藏  |  浏览/下载：3/0  |  提交时间：2020/07/01 Frondoplysins A and B, Unprecedented Terpene-Alkaloid Bioconjugates from Dysidea frondosa 期刊论文 ORGANIC LETTERS, 2019, 卷号: 21, 期号: 16, 页码: 6190-6193 作者:  Jiao, Wei-Hua;  Li, Jing;  Zhang, Meng-Meng;  Cui, Jie;  Gui, Yu-Han 收藏  |  浏览/下载：2/0  |  提交时间：2020/07/01 Structure-Based Design of 5-Methylpyrimidopyridone Derivatives as New Wild-Type Sparing Inhibitors of the Epidermal Growth Factor Receptor Triple Mutant (EGFR(L858R/T790M/C797S)) 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 15, 页码: 7302-7308 作者:  Shen, Jiayi;  Zhang, Tao;  Zhu, Su-Jie;  Sun, Min;  Tong, Linjiang 收藏  |  浏览/下载：31/0  |  提交时间：2020/07/01 Discovery and Biological evaluation of pyrimido[4,5-d] pyrimidine-2,4(1H, 3H)-dione derivatives as potent Bruton's tyrosine kinase inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 15, 页码: 3390-3395 作者:  Diao, Yanyan;  Fang, Xiaoyu;  Song, Peiran;  Lai, Mengzhen;  Tong, Linjiang 收藏  |  浏览/下载：25/0  |  提交时间：2020/07/01 Bruton's tyrosine kinase  B-cell malignancies  Potent inhibitors  Structure-activity relationship  Cellular activities   Discovery of a novel third generation EGFR TKI and identification of its potential mechanism of resistance 期刊论文 CANCER RESEARCH, 2019, 卷号: 79, 期号: 13, 页码: 2 作者:  Zhang, Tao;  Qu, Rong;  Chen, Chengbin;  Tong, Linjiang;  Feng, Fang 收藏  |  浏览/下载：4/0  |  提交时间：2020/07/01 Discovery of Potent and Noncovalent Reversible EGFR Kinase Inhibitors of EGFR(L858R/T790M/C797S) 期刊论文 ACS MEDICINAL CHEMISTRY LETTERS, 2019, 卷号: 10, 期号: 6, 页码: 869-873 作者:  Li, Qiannan;  Zhang, Tao;  Li, Shiliang;  Tong, Linjiang;  Li, Junyu 收藏  |  浏览/下载：22/0  |  提交时间：2020/07/01 EGFR  mutant  inhibitor  C797S   Synthesis and Biological Evaluation of Oxopyrido[2,3-d] Pyrimidine-7-ones Derivatives as Covalent L85812/T790M Mutant Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors 期刊论文 LETTERS IN DRUG DESIGN & DISCOVERY, 2019, 卷号: 16, 期号: 8, 页码: 826-834 作者:  Niu, Ao;  Wang, Yang;  Yang, Yushe;  Wei, Jianhai;  Ding, Jian 收藏  |  浏览/下载：12/0  |  提交时间：2020/07/01 Non-small cell lung cancer  irreversible inhibitors  EGFR(T79014)( )mutant  anti-tumor  xenograft model  cell proliferation   c11anovelfibroblastgrowthfactorreceptor1fgfr1inhibitorsuppressesbreastcancermetastasisandangiogenesis 期刊论文 actapharmacologicasinica, 2019, 卷号: 40, 期号: 6, 页码: 823 作者:  Chen Zhuo;  Tong Linjiang;  Tang Baiyou;  Liu Hongyan;  Wang Xin 收藏  |  浏览/下载：5/0  |  提交时间：2020/07/01 SELECTIVE INHIBITOR  THERAPEUTIC TARGET  DISCOVERY  ACTIVATION  EXPRESSION  PATHWAY  POTENT  C11  FGFR1 inhibitor  antitumor  breast cancer  metastasis  angiogenesis   Phosphorylation of LIFR promotes prostate cancer progression by activating the AKT pathway 期刊论文 CANCER LETTERS, 2019, 卷号: 451, 页码: 110-121 作者:  Shao, Jialiang;  Zhu, Wencheng;  Ding, Yufeng;  Zhu, Hongwen;  Jing, Xiaoqian 收藏  |  浏览/下载：33/0  |  提交时间：2020/07/01 LIFR  Phosphorylation  Prostate cancer  AKT