Frondoplysins A and B, Unprecedented Terpene-Alkaloid Bioconjugates from Dysidea frondosa | |
Jiao, Wei-Hua1; Li, Jing1,2; Zhang, Meng-Meng3; Cui, Jie1; Gui, Yu-Han1; Zhang, Yun4; Li, Jing-Ya3; Liu, Ke-Chun4; Lin, Hou-Wen1 | |
刊名 | ORGANIC LETTERS |
2019-08-16 | |
卷号 | 21期号:16页码:6190-6193 |
ISSN号 | 1523-7060 |
DOI | 10.1021/acs.orglett.9b01754 |
通讯作者 | Lin, Hou-Wen(franklin67@126.com) |
英文摘要 | The chemical investigation of the marine sponge Dysidea frondosa discovered a pair of unprecedented bioconjugates that are composed of a meroterpene and an unusual psammaplysin alkaloid. The structures of frondoplysins A (1) and B (2) were characterized by analysis of HRMS and NMR data coupled with single-crystal X-ray diffraction. Frondoplysin A was found to be a potent inhibitor targeting protein-tyrosine phosphatase 1B (PTP1B) with an IC50 value of 0.39 mu M. |
资助项目 | National Key Research and Development Program of China[2018YFC0310901] ; National Natural Science Foundation of China[41576130] ; National Natural Science Foundation of China[U160S221] ; National Natural Science Foundation of China[81602982] ; National Natural Science Foundation of China[81703624] |
WOS关键词 | TYROSINE-PHOSPHATASE 1B ; INHIBITORY-ACTIVITY ; INSULIN SENSITIVITY ; ALPHA-GLUCOSIDASE ; PTP1B ; SESQUITERPENOIDS ; ACIDS |
WOS研究方向 | Chemistry |
语种 | 英语 |
出版者 | AMER CHEMICAL SOC |
WOS记录号 | WOS:000481979100003 |
内容类型 | 期刊论文 |
源URL | [http://119.78.100.183/handle/2S10ELR8/288561] |
专题 | 中国科学院上海药物研究所 |
通讯作者 | Lin, Hou-Wen |
作者单位 | 1.Shanghai Jiao Tong Univ, Sch Med, Ren Ji Hosp, State Key Lab Oncogene & Related Genes,Res Ctr Ma, Shanghai 200127, Peoples R China 2.Shanghai Acad Agr Sci, Biotech Res Inst, Shanghai Key Lab Agr Genet & Breeding, Shanghai 201106, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China 4.Qilu Univ Technol, Inst Biol, Jinan 250103, Shandong, Peoples R China |
推荐引用方式 GB/T 7714 | Jiao, Wei-Hua,Li, Jing,Zhang, Meng-Meng,et al. Frondoplysins A and B, Unprecedented Terpene-Alkaloid Bioconjugates from Dysidea frondosa[J]. ORGANIC LETTERS,2019,21(16):6190-6193. |
APA | Jiao, Wei-Hua.,Li, Jing.,Zhang, Meng-Meng.,Cui, Jie.,Gui, Yu-Han.,...&Lin, Hou-Wen.(2019).Frondoplysins A and B, Unprecedented Terpene-Alkaloid Bioconjugates from Dysidea frondosa.ORGANIC LETTERS,21(16),6190-6193. |
MLA | Jiao, Wei-Hua,et al."Frondoplysins A and B, Unprecedented Terpene-Alkaloid Bioconjugates from Dysidea frondosa".ORGANIC LETTERS 21.16(2019):6190-6193. |
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