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科研机构
中南大学 [12]
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期刊论文 [12]
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2018 [1]
2017 [3]
2016 [3]
2015 [2]
2012 [2]
2010 [1]
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Inhibition of Rac1 ameliorates neuronal oxidative stress damage via reducing Bcl-2/Rac1 complex formation in mitochondria through PI3K/Akt/mTOR pathway
期刊论文
Experimental Neurology, 2018, 卷号: 300, 页码: 149-166
作者:
Pan, Yundan
;
Wang, Na
;
Xia, Pingping
;
Wang, E.
;
Guo, Qulian
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/03
Cerebral ischemia
Hyperglycemia
Oxidative stress
Rac1
Neuroprotection
Phosphatidylinositol 3-kinase (PI3K)
Metformin, beyond an insulin sensitizer, targeting heart and pancreatic β cells
期刊论文
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2017, 卷号: 1863, 期号: 8, 页码: 1984-1990
作者:
Yang, Xin
;
Xu, Zhipeng
;
Zhang, Chunlan
;
Cai, Zixin
;
Zhang, Jingjing*
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2019/12/03
A1c
glycated hemoglobin
AACE
American Association of Clinical Endocrinologists
ACC
acetyl-CoA carboxylase
ADA
American Diabetes Association
Akt/PKB
tyrosine kinase/protein kinase B
AMP
adenosine monophosphate
AMPK
adenosine monophosphate-activated protein
Ang II
angiotensin II
ATP
adenosine triphosphate
BAT
brown adipose tissue
CHOP
CEBP-homologous protein
CEBP
CCAAT enhancer binding protein
CoA
coenzyme A
DPP
Diabetes Prevention Program
EASD
European Association for the Study of Diabetes
eNOS
endothelial nitric oxide synthase
ER
endoplasmic reticulum
FDA
Food and Drug Administration
FFA
free fatty acid
FOXO1
forkhead box protein O1
G6P
glucose 6-phosphate
GDM
gestational diabetes mellitus
GIPR
glucose-dependent insulinotropic polypeptide receptor
GLP-1R
glucagon-like peptide-1 receptor
GLUT1
glucose transporter-1
GLUT4
glucose transporter type 4
GLUTs
glucose transporters
G6P
glucose 6-phosphate, glucose transporter-1
GPR40
G protein-coupled receptor 40
HbA1c
hemoglobin A1c
HGP
hepatic glucose production
HSL
hormone sensitive lipase
IL-6
interleukin 6
INS-1
insulinoma cells in rat
IR
insulin resistance
IRS-1
insulin receptor substrate 1
JNK
c-Jun. N-terminal kinase
Kir6.2
inwardly rectifying potassium/kalium channel
LDs
lipid droplets
LDL
low density lipoprotein
LV
left ventricular
MIN6 cells
mouse insulinoma cells
MAPK
mitogen-activated protein kinases
mPTP
mitochondrial permeability transition pore opening
mTOR
mammalian target of rapamycin
NADPH
nicotinamide adenine dinucleotide phosphate
NF-kappaB
nuclear factors-kappa B
NIT-1 cells
insulinoma cells
p70S6K
p70 ribosomal S6 kinase
PA
palmitic acid
NOS
NADPH oxidase
p38 MAPK
p38 mitogen-activated protein kinase
PA
palmitic acid
PCOS
polycystic ovary syndrome
PGC-1α
peroxisome proliferator-activated receptor-g coactivator-1α
PI3K
phosphatidylinositol 3-kinase
PKB
protein kinase B
PKC
protein kinase C
PPARα
peroxisome-proliferator activated receptor α
PTP
permeability transition pore
RCT
randomized controlled trial
RISK
reperfusion injury salvage kinase
ROS
reactive oxygen species
SERCA2
reticulum sarcoplasmic Ca2 +-ATPase
RISK
reperfusion injury salvage kinase
Smad3
mothers against decapentaplegic homolog 3
SRC-2
steroid receptor coactivator 2
T1DM
Type 1 diabetes mellitus
T2DM
Type 2 diabetes mellitus
TGFβ1
transforming growth factor β1
TLR4
Toll-like receptor
TNF-α
tumor necrosis factor α
TR4
testicular receptor 4
UKPDS
United Kingdom Prospective Diabetes Study
VLDL
very low density lipoprotein
Metformin
Pancreatic β Cells
Heart failure
Insulin sensitizer
The PI3K/Akt/mTOR pathway is involved in CVB3-induced autophagy of HeLa cells
期刊论文
International Journal of Molecular Medicine, 2017, 卷号: 40, 期号: 1, 页码: 182-192
作者:
Chang, Huan
;
Li, Xin
;
Cai, Qian
;
Li, Chunyun
;
Tian, Lang
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/12/03
autophagy
mammalian target of rapamycin
coxsackievirus B3
phosphatidylinositol 3-kinase
viral myocarditis
Combination of metformin with chemotherapeutic drugs via different molecular mechanisms
期刊论文
Cancer Treatment Reviews, 2017, 卷号: 54, 页码: 24-33
作者:
Peng, Mei*
;
Darko, Kwame Oteng
;
Tao, Ting
;
Huang, Yanjun
;
Su, Qiongli
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/12/03
AIs
aromatase inhibitors
AMPK
Adenosine Monophosphate-Activated Protein Kinase
AR
androgen
ATM
Ataxia Telangiectasia Mutated
ATP
Adenosine Triphosphate
BCSS
breast cancer specific survival
CK-MB
Creatine Kinase-MB
CREB1
cAMP Response Element-Binding Protein 1
CSC
cancer stem cell
DFS
disease-free survival
DHFU
dihydrofluorouracil
DPD
dihydropyrimidine dehydrogenase
EpCAM
Epithelial Cell Adhesion Molecule
ER
estrogen
ERCC1
excision repair cross-complementary 1
ERK
extracellular signal-regulated kinases
EZH2
enhancer of zeste homolog 2
FdUMP
fluorodeoxyuridine monophosphate
FdUTP
fluorodeoxyuridine triphosphate
FHC
ferritin heavy chain
FUTP
fluorouridine triphosphate
HbA1C
hemoglobin A1c
HER
Human Epidermal Growth Factor Receptor
HIF-1α
hypoxia-inducible factor-1α
HK
hexokinase
IGF1R
insulin growth factor 1 receptor
LDH
lactate dehydrogenase
MDA
Muscular Dystrophy Association
MMP
Matrix Metallopeptidase
MRP1
multidrug resistance-associated protein 1
mTOR
mammalian target of rapamycin
MTX
methotrexate
NCCN
National Comprehensive Cancer Network
OS
overall survival
pCR
Pathologic Complete Response
PDGFR
platelet-derived growth factor receptors
PFS
progression-free survival
PKA
protein kinase A
PR
progesterone receptor
RFS
relapse-free survival
SOD
superoxide dismutase
TAM
tamoxifen
TCA
tricarboxlic acid
TS
thymidylate synthase
Combination
Mechanisms
Metformin
Chemotherapeutic drugs
Bridges between mitochondrial oxidative stress, ER stress and mTOR signaling in pancreatic β cells
期刊论文
Cellular Signalling, 2016, 卷号: 28, 期号: 8, 页码: 1099-1104
作者:
Wang, Jing
;
Yang, Xin
;
Zhang, Jingjing*
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/12/03
4E-BP1
4E binding protein
AMPK
AMP-activated protein kinase
ATF6
activating transcription factor 6
ATP
adenosine triphosphate
DEPTOR
DEP domain containing mTOR-interacting protein
CI
complexes I
CII
complex II
CIII
complex III
CIV
complex IV
CV
complex V
eIF2α
Eukaryotic Initiation Factor 2α
ER
Endoplasmic Reticulum
ERAD
ER-associated degradation
ERO1α
ER oxidoreductase 1 α
FoxO1
Forkhead box O1
GβL
G Protein β Subunit Like Protein
GRP78
78 kDa glucose-regulated protein precursor
GSIS
glucose-stimulated insulin secretion
IRE1
Inositol-requiring enzyme 1
IRS1
Insulin receptor substrate 1
IRS2
Insulin receptor substrate 2
mLST8
mammalian lethal with sec-13 protein 8
mSin1
the mammalian stress-activated MAP kinase-interaction protein 1
mtDNA
mitochondrial deoxyribonucleic acid
mTOR
mammalian TOR
mTORC1
mTOR complex 1
mTORC2
mTOR complex 2
NADPH oxidase
Nicotinamide adenine dinucleotide phosphate-oxidase
NOS
nitric oxide synthase
O2–·
superoxide anion
H2O2
hydrogen peroxide
OH·
hydroxyl radical
3O2
triplet-state molecular oxygen
OXPHOS
oxidative phosphorylation
CAT
catalase
GPx
glutathioneperoxidase
PERK
Protein kinase R-like endoplasmic reticulum kinase
PDI
ER protein disulfide isomerases
PI3K
the phosphoinositide3-kinase
PRAS40
40-kDa proline-rich Akt substrate
PRAS40
the 40-kDa proline-rich Akt substrate
PROTOR
the protein observed with RICTOR
RAPTOR
regulatory-associated protein of mTOR
RICTOR
The rapamycin-insensitive companion of mTOR
REDD1
DNA damage response 1
RNS
reactive nitrogen species
ROS
reactive oxygen species
RNS
reactive nitrogen species
S6K
S6 kinase
SOD
superoxidedismutase
T1DM
Type 1 diabetes mellitus
T2DM
Type 2 diabetes mellitus
TOR
the target of rapamycin
TSC2
Tuberous sclerosis 2
UPR
unfolded protein response
Mitochondrial oxidative stress
ER stress
mTOR
Pancreatic β cells
Renoprotective approaches and strategies in acute kidney injury
期刊论文
Pharmacology and Therapeutics, 2016, 卷号: 163, 页码: 58-73
作者:
Yang, Yuan
;
Song, Meifang
;
Liu, Yu
;
Liu, Hong
;
Sun, Lin
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/12/03
ACTH
Adrenocorticotropic hormone
AIF
Apoptosis inducing factor
AKI
Acute kidney injury
BMSC
Bone marrow derived stem cells
CIN
Contrast-induced nephropathy
COMP-Ang1
Cartilage oligomeric matrix protein-angiopoietin-1
CysLT1R
Cysteinyl leukotriene-1 receptor
DMARD
Disease-modifying antirheumatic drugs
eNOS
Endothelial nitric oxide synthase
eEPCs
Endothelial progenitor cells
HDAC
Histone deacetylase
HSPC
Hematopoietic stem and progenitor cells
IRI
Ischemia–reperfusion injury
ICAM-1
Intercellular adhesion molecule-1
JNK
c-Jun N-terminal kinase
KIF3B
Kinesin family member 3B
KIM-1
Kidney injury molecule 1
MAPK
Mitogen-activated protein kinase
MCP-1
Monocyte chemotactic protein-1
α-MSH
Alpha-melanocyte-stimulating hormone
MFG-E8
Milk fat globule-epidermal growth factor-factor VIII
MPT
Mitochondrial permeability transition
MSCs
Mesenchymal stem cells
NGAL
Neutrophil gelatinase-associated lipocalin
MDM2
Murine double minute-2
MMP-2
Matrix metallopeptidase 2
mTOR
Mammalian target of rapamycin
PI3K
Phosphatidylinositol-3 kinase
PACAP
Pituitary adenylate cyclase activating polypeptide
RAAS
Renin–angiotensin–aldosterone system
RANTES
Regulated upon activation normal T-cell expressed and secreted
RIP1
Receptor-interacting protein 1
TNF-α
Tumor necrosis factor-alpha
TWEAK
TNF-like weak inducer of apoptosis
VDRA
Vitamin D receptor agonist
Acute kidney injury
Kidney protection
Kidney repair
Renoprotection
Ischemia–reperfusion
Nephrotoxicity
Huperzine A Alleviates Oxidative Glutamate Toxicity in Hippocampal HT22 Cells via Activating BDNF/TrkB-Dependent PI3K/Akt/mTOR Signaling Pathway
期刊论文
Cellular and Molecular Neurobiology, 2016, 卷号: 36, 期号: 6, 页码: 915-925
作者:
Mao, Xiao-Yuan*
;
Zhou, Hong-Hao
;
Li, Xi
;
Liu, Zhao-Qian*
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/12/03
Huperzine A
Oxidative glutamate toxicity
HT22 cells
Brain-derived neurotrophic factor
Phosphatidylinositol 3 kinase
Apoptosis
Reciprocal regulation of cilia and autophagy via the MTOR and proteasome pathways
期刊论文
Autophagy, 2015, 卷号: 11, 期号: 4, 页码: 607-616
作者:
Wang, Shixuan
;
Livingston, Man J.
;
Su, Yunchao
;
Dong, Zheng*
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/12/03
3-MA, 3-methyladenine
70kDa, polypeptide 1
ANKS6, ankyrin repeat and sterile alpha motif domain containing 6
ATG/atg, autophagy-related
Ac-TUBA, acetylated-tubulin alpha
Baf, bafilomycin A1
CF, confluence
CQ, chloroquine
DAPI, 4'-6-diamidino-2-phenylindole
FBS, fetal bovine serum
HK2, human kidney proximal tubular cells
IFT, intraflagellar transport
KAP3, kinesin family-associated protein 3
KD, knockdown
KIF3A/3B, kinesin family member 3A/3B
KO, knockout
LTA, lotus tetragonolobus agglutinin
MAP1LC3B/LC3B, microtubule-associated protein 1 light chain 3 beta
MEF, mouse embryonic fibroblast
MTOR
MTOR, mechanistic target of rapamycin
OFD1, oral-ficial-digital syndrome 1
PBS, phosphate-buffered saline
PKD, polycystic kidney disease
RKRB, Krebs-Henseleit saline containing 25 mM NaHCO3
RPS6KB1, ribosomal protein S6 kinase
Rapa, rapamycin
SD, standard deviation
autophagy
cilia
polycystic kidney disease
proteasome
Interleukin-1β plays a role in the pathogenesis of mesial temporal lobe epilepsy through the PI3K/Akt/mTOR signaling pathway in hippocampal neurons
期刊论文
Journal of Neuroimmunology, 2015, 卷号: 282, 页码: 110-117
作者:
Xiao, Zhaohua
;
Peng, Jing
;
Yang, Lifen
;
Kong, Huimin
;
Yin, Fei*
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2019/12/03
Epilepsy
Hippocampus
Inflammation
Interleukin-1beta
MTLE
Neuron
Phosphatidylino-sitol 3-kinase
mTOR
p70S6K
Leptin regulates proliferation and apoptosis of colorectal carcinoma through PI3K/Akt/mTOR signalling pathway
期刊论文
Journal of Biosciences, 2012, 卷号: 37, 期号: 1, 页码: 91-101
作者:
Di Wang
;
Jian Chen
;
Hui Chen
;
Zhi Duan
;
Qimei Xu
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/03
Colorectal carcinoma
HCT-116
leptin
mammalian target of rapamycin (mTOR)
phosphatidylinositol 3-kinase PI3K
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