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科研机构
中南大学 [6]
内容类型
期刊论文 [6]
发表日期
2017 [1]
2016 [1]
2014 [1]
2012 [2]
2011 [1]
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专题:中南大学
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Metformin, beyond an insulin sensitizer, targeting heart and pancreatic β cells
期刊论文
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2017, 卷号: 1863, 期号: 8, 页码: 1984-1990
作者:
Yang, Xin
;
Xu, Zhipeng
;
Zhang, Chunlan
;
Cai, Zixin
;
Zhang, Jingjing*
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2019/12/03
A1c
glycated hemoglobin
AACE
American Association of Clinical Endocrinologists
ACC
acetyl-CoA carboxylase
ADA
American Diabetes Association
Akt/PKB
tyrosine kinase/protein kinase B
AMP
adenosine monophosphate
AMPK
adenosine monophosphate-activated protein
Ang II
angiotensin II
ATP
adenosine triphosphate
BAT
brown adipose tissue
CHOP
CEBP-homologous protein
CEBP
CCAAT enhancer binding protein
CoA
coenzyme A
DPP
Diabetes Prevention Program
EASD
European Association for the Study of Diabetes
eNOS
endothelial nitric oxide synthase
ER
endoplasmic reticulum
FDA
Food and Drug Administration
FFA
free fatty acid
FOXO1
forkhead box protein O1
G6P
glucose 6-phosphate
GDM
gestational diabetes mellitus
GIPR
glucose-dependent insulinotropic polypeptide receptor
GLP-1R
glucagon-like peptide-1 receptor
GLUT1
glucose transporter-1
GLUT4
glucose transporter type 4
GLUTs
glucose transporters
G6P
glucose 6-phosphate, glucose transporter-1
GPR40
G protein-coupled receptor 40
HbA1c
hemoglobin A1c
HGP
hepatic glucose production
HSL
hormone sensitive lipase
IL-6
interleukin 6
INS-1
insulinoma cells in rat
IR
insulin resistance
IRS-1
insulin receptor substrate 1
JNK
c-Jun. N-terminal kinase
Kir6.2
inwardly rectifying potassium/kalium channel
LDs
lipid droplets
LDL
low density lipoprotein
LV
left ventricular
MIN6 cells
mouse insulinoma cells
MAPK
mitogen-activated protein kinases
mPTP
mitochondrial permeability transition pore opening
mTOR
mammalian target of rapamycin
NADPH
nicotinamide adenine dinucleotide phosphate
NF-kappaB
nuclear factors-kappa B
NIT-1 cells
insulinoma cells
p70S6K
p70 ribosomal S6 kinase
PA
palmitic acid
NOS
NADPH oxidase
p38 MAPK
p38 mitogen-activated protein kinase
PA
palmitic acid
PCOS
polycystic ovary syndrome
PGC-1α
peroxisome proliferator-activated receptor-g coactivator-1α
PI3K
phosphatidylinositol 3-kinase
PKB
protein kinase B
PKC
protein kinase C
PPARα
peroxisome-proliferator activated receptor α
PTP
permeability transition pore
RCT
randomized controlled trial
RISK
reperfusion injury salvage kinase
ROS
reactive oxygen species
SERCA2
reticulum sarcoplasmic Ca2 +-ATPase
RISK
reperfusion injury salvage kinase
Smad3
mothers against decapentaplegic homolog 3
SRC-2
steroid receptor coactivator 2
T1DM
Type 1 diabetes mellitus
T2DM
Type 2 diabetes mellitus
TGFβ1
transforming growth factor β1
TLR4
Toll-like receptor
TNF-α
tumor necrosis factor α
TR4
testicular receptor 4
UKPDS
United Kingdom Prospective Diabetes Study
VLDL
very low density lipoprotein
Metformin
Pancreatic β Cells
Heart failure
Insulin sensitizer
Bridges between mitochondrial oxidative stress, ER stress and mTOR signaling in pancreatic β cells
期刊论文
Cellular Signalling, 2016, 卷号: 28, 期号: 8, 页码: 1099-1104
作者:
Wang, Jing
;
Yang, Xin
;
Zhang, Jingjing*
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/12/03
4E-BP1
4E binding protein
AMPK
AMP-activated protein kinase
ATF6
activating transcription factor 6
ATP
adenosine triphosphate
DEPTOR
DEP domain containing mTOR-interacting protein
CI
complexes I
CII
complex II
CIII
complex III
CIV
complex IV
CV
complex V
eIF2α
Eukaryotic Initiation Factor 2α
ER
Endoplasmic Reticulum
ERAD
ER-associated degradation
ERO1α
ER oxidoreductase 1 α
FoxO1
Forkhead box O1
GβL
G Protein β Subunit Like Protein
GRP78
78 kDa glucose-regulated protein precursor
GSIS
glucose-stimulated insulin secretion
IRE1
Inositol-requiring enzyme 1
IRS1
Insulin receptor substrate 1
IRS2
Insulin receptor substrate 2
mLST8
mammalian lethal with sec-13 protein 8
mSin1
the mammalian stress-activated MAP kinase-interaction protein 1
mtDNA
mitochondrial deoxyribonucleic acid
mTOR
mammalian TOR
mTORC1
mTOR complex 1
mTORC2
mTOR complex 2
NADPH oxidase
Nicotinamide adenine dinucleotide phosphate-oxidase
NOS
nitric oxide synthase
O2–·
superoxide anion
H2O2
hydrogen peroxide
OH·
hydroxyl radical
3O2
triplet-state molecular oxygen
OXPHOS
oxidative phosphorylation
CAT
catalase
GPx
glutathioneperoxidase
PERK
Protein kinase R-like endoplasmic reticulum kinase
PDI
ER protein disulfide isomerases
PI3K
the phosphoinositide3-kinase
PRAS40
40-kDa proline-rich Akt substrate
PRAS40
the 40-kDa proline-rich Akt substrate
PROTOR
the protein observed with RICTOR
RAPTOR
regulatory-associated protein of mTOR
RICTOR
The rapamycin-insensitive companion of mTOR
REDD1
DNA damage response 1
RNS
reactive nitrogen species
ROS
reactive oxygen species
RNS
reactive nitrogen species
S6K
S6 kinase
SOD
superoxidedismutase
T1DM
Type 1 diabetes mellitus
T2DM
Type 2 diabetes mellitus
TOR
the target of rapamycin
TSC2
Tuberous sclerosis 2
UPR
unfolded protein response
Mitochondrial oxidative stress
ER stress
mTOR
Pancreatic β cells
Increased expression of IRS-1 is associated with lymph node metastasis in nasopharyngeal carcinoma
期刊论文
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2014, 卷号: 7, 期号: 9, 页码: 6117-6124
作者:
Luo, Jiadi
;
Wen, Qiuyuan
;
Li, Jiao
;
Xu, Lina
;
Chu, Shuzhou
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/03
Insulin receptor substrate (IRS)
biomarker
insulin receptor substrate 1 (IRS-1)
metastasis
nasopharyngeal carcinoma (NPC)
Downregulation of IRS-1 promotes metastasis of head and neck squamous cell carcinoma
期刊论文
Oncology Reports, 2012, 卷号: 28, 期号: 2, 页码: 659-667
作者:
Luo, Xuan
;
Fan, Songqing
;
Huang, Wenbin
;
Zhai, Sulan
;
Ma, Zhuo
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/03
insulin receptor substrate 1
head and neck squamous cell carcinoma
metastasis
E-cadherin
miR-9
hsa-miR-96 up-regulates MAP4K1 and IRS1 and may function as a promising diagnostic marker in human bladder urothelial carcinomas
期刊论文
Molecular Medicine Reports, 2012, 卷号: 5, 期号: 1, 页码: 260-265
作者:
Wang, Yi
;
Luo, Hongmei
;
Li, Yangle
;
Chen, Tieding
;
Wu, Shengpeng
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/03
hsa-miR-96
diagnostic marker
MAP4K1
insulin receptor substrate 1
Inhibition of ceramide synthesis reverses endothelial dysfunction and atherosclerosis in streptozotocin-induced diabetic rats
期刊论文
Diabetes Research and Clinical Practice, 2011, 卷号: 93, 期号: 1, 页码: 77-85
作者:
Li Chun
;
Zhou Junlin
;
Wang Aimin
;
Li Niansheng
;
Chen Benmei
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/03
DC group
diabetic control group
NC group
normal control group
MTD group
myriocin treated diabetic group
SPT
serine palmitoyl-CoA transferase
EDVD
endothelium-dependent vasodilation
EC
endotheliocyte
IRS
insulin receptor substrate
PI3K
phosphatidylinositol 3-kinase
AKT/PKB
protein kinase B
eNOS
endothelial nitric oxide synthase
NO
nitric oxide
TNF-a
tumor necrosis factor α
HUVECs
human umbilical vein endothelial cells
Homa-IR
homeostasis model assessment-insulin resistance
HbA1c
glycated hemoglobin A1c
TG
triglyeride
TC
total cholesterol
LDL
low density lipoprotein
HDL
high density lipoprotein
ALT
alanine aminotransferase
AST
aspartate aminotransferase
FBS
fasting blood sugar
PBS
postprandial blood sugar
Qod
quaque (other) die
Ceramide
EDVD
eNOS
Atherosclerosis
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