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Early Detection of Lung Cancer Using DNA Promoter Hypermethylation in Plasma and Sputum 期刊论文
Clinical Cancer Research, 2017, 卷号: 23, 期号: 8, 页码: 1998-2005
作者:  Hulbert, Alicia;  Jusue-Torres, Ignacio;  Stark, Alejandro;  Chen, Chen;  Rodgers, Kristen
收藏  |  浏览/下载：2/0  |  提交时间：2019/12/03
Down-regulation of TCF21 by hypermethylation induces cell proliferation, migration and invasion in colorectal cancer 期刊论文
Biochemical and Biophysical Research Communications, 2016, 卷号: 469, 期号: 3, 页码: 430-436
作者:  Dai, Youyi;  Duan, Huaxin;  Duan, Chaojun;  Zhou, Rongrong;  He, Yuxiang
收藏  |  浏览/下载：3/0  |  提交时间：2019/12/03
Hypermethylation-Associated Silencing of miR-125a and miR-125b: A Potential Marker in Colorectal Cancer 期刊论文
Disease markers, 2015, 卷号: 2015, 页码: 345080
作者:  Chen, Hui*;  Xu, Zhiying
收藏  |  浏览/下载：1/0  |  提交时间：2019/12/03
Clinicopathological significance and potential drug target of CDH1 in breast cancer: a meta-analysis and literature review 期刊论文
Drug Design, Development and Therapy, 2015, 卷号: 9, 页码: 5277-5285
作者:  Huang, Ruixue;  Ding, Ping;  Yang, Fei*
收藏  |  浏览/下载：15/0  |  提交时间：2019/12/03
CDH1  as a tumor suppressor gene  contributes sporadic breast cancer (BC) progression. However  the association between CDH1 hypermethylation and BC  and its clinicopathological significance remains unclear. We conducted a meta-analysis to investigate the relationship between the CDH1 methylation profile and the major clinicopathological features. A detailed literature was searched through the electronic databases PubMed  Web of Science™  and EMBASE™ for related research publications. The data were extracted and assessed by two reviewers independently. Odds ratios (ORs) with corresponding confidence intervals (CIs) were calculated and summarized respectively. The frequency of CDH1 methylation was significantly higher in invasive ductal carcinoma than in normal breast tissues (OR =5.83  95% CI 3.76–9.03  P<0.00001). CDH1 hypermethylation was significantly higher in estrogen receptor (ER)-negative BC than in ER-positive BC (OR =0.62  95% CI 0.43–0.87  P=0.007). In addition  we found that the CDH1 was significantly methylated in HER2-negative BC than in HER2-positive BC (OR =0.26  95% CI 0.15–0.44  P<0.00001). However  CDH1 methylation frequency was not associated with progesterone receptor (PR) status  or with grades  stages  or lymph node metastasis of BC patients. Our results indicate that CDH1 hypermethylation is a potential novel drug target for developing personalized therapy. CDH1 hypermethylation is strongly associated with ER-negative and HER2-negative BC  respectively  suggesting CDH1 methylation status could contribute to the development of novel therapeutic approaches for the treatment of ER-negative or HER2-negative BC with aggressive tumor biology.  
DNA methylation of hMLH1 correlates with the clinical response to cisplatin after a surgical resection in Non-small cell lung cancer 期刊论文
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2015, 卷号: 8, 期号: 5, 页码: 5457-5463
作者:  Wu, Fang;  Lu, Min;  Qu, Lu;  Li, Dai-Qiang;  Hu, Chun-Hong*
收藏  |  浏览/下载：4/0  |  提交时间：2019/12/03
Epigenetic repression of Kruppel-like factor 4 through Dnmt1 contributes to EMT in renal fibrosis. 期刊论文
International Journal of Molecular Medicine, 2015, 卷号: 35, 期号: 6, 页码: 1596-1602
作者:  Xiao, Xiangcheng;  Tang, Wenbin;  Yuan, Qiongjing;  Peng, Ling;  Yu, Pingping*
收藏  |  浏览/下载：3/0  |  提交时间：2019/12/03
Hypermethylation of the TGF-β target, ABCA1 is associated with poor prognosis in ovarian cancer patients 期刊论文
Clinical Epigenetics, 2015, 卷号: 7, 期号: 1, 页码: 1
作者:  Chou, Jian-Liang;  Huang, Rui-Lan;  Shay, Jacqueline;  Chen, Lin-Yu;  Lin, Sheng-Jie
收藏  |  浏览/下载：4/0  |  提交时间：2019/12/03
Promoter hypermethylation along with LOH, but not mutation, contributes to inactivation of DLC‐1 in nasopharyngeal carcinoma 期刊论文
Molecular Carcinogenesis, 2014, 卷号: 53, 期号: 11, 页码: 858-870
作者:  Feng, Xiangling r;  Ren, Caiping*;  Zhou, Wen;  Liu, Weidong;  Zeng, Liang
收藏  |  浏览/下载：1/0  |  提交时间：2019/12/03
Hypermethylation of DDAH2 promoter contributes to the dysfunction of endothelial progenitor cells in coronary artery disease patients 期刊论文
Journal of Translational Medicine, 2014, 卷号: 12, 期号: 1, 页码: 170
作者:  Niu, Pan-Pan;  Cao, Yu;  Gong, Ting;  Guo, Jin-Hui;  Zhang, Bi-Kui*
收藏  |  浏览/下载：7/0  |  提交时间：2019/12/03
Association of genetic variants in and promoter hypermethylation of CDH1 with gastric cancer: a meta-analysis. 期刊论文
Medicine (United States), 2014, 卷号: 93, 期号: 19, 页码: e107
作者:  Jing, Huiquan*;  Dai, Fei;  Zhao, Chuntao;  Yang, Juan;  Li, Lizhuo
收藏  |  浏览/下载：4/0  |  提交时间：2019/12/03

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