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CORC

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Impurity Identification and Scale-Up of a Novel Glycopeptide Antibiotic 期刊论文
ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2021, 卷号: 25, 期号: 11, 页码: 2390-2402
作者:  Jiao, Shang;  Guan, Dongliang;  Xu, Lili;  Liu, Bo;  Shi, Weiwei
收藏  |  浏览/下载：19/0  |  提交时间：2022/01/18
Discovery and Development of a Potent, Selective, and Orally Bioavailable CHK1 Inhibitor Candidate: 5-((4-((3-Amino-3-methylbutyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)picolinonitrile 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 20, 页码: 15069-15090
作者:  Jin, Tingting;  Xu, Lei;  Wang, Peipei;  Hu, Xiaobei;  Zhang, Runyuan
收藏  |  浏览/下载：24/0  |  提交时间：2022/01/04
Identification of methyl (5-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinopyrrolo[2,1-f][1,2,4]triazin-2-yl)-4-(trifluoromethyl)pyridin-2-yl)carbamate (CYH33) as an orally bioavailable, highly potent, PI3K alpha inhibitor for the treatment of advanced solid tumors 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 209, 页码: 10
作者:  Xiang, Hao-Yue;  Wang, Xiang;  Chen, Yan-Hong;  Zhang, Xi;  Tan, Cun
收藏  |  浏览/下载：36/0  |  提交时间：2021/05/24
Substitution Effect of the Trifluoromethyl Group on the Bioactivity in Medicinal Chemistry: Statistical Analysis and Energy Calculations 期刊论文
JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2020, 卷号: 60, 期号: 12, 页码: 6242-6250
作者:  Abula, Amina;  Xu, Zhijian;  Zhu, Zhengdan;  Peng, Cheng;  Chen, Zhaoqiang
收藏  |  浏览/下载：26/0  |  提交时间：2021/05/24
Palladium-catalyzed fluoroacylation of (Hetero)arylboronic acid with fluorothioacetates at ambient temperature 期刊论文
TETRAHEDRON LETTERS, 2020, 卷号: 61, 期号: 16, 页码: 4
作者:  Yi, Xing;  Cao, Ya-Fang;  Wang, Xing;  Xu, Hui;  Ban, Shu-Rong
收藏  |  浏览/下载：26/0  |  提交时间：2020/07/01
Synthesis of Aryl Propionamide Scaffold Containing a Pentafluorosulfanyl Moiety as SARMs 期刊论文
MOLECULES, 2019, 卷号: 24, 期号: 23, 页码: 13
作者:  Shao, Pingxuan;  Zhou, Yan;  Yang, Dehua;  Wang, Ming-Wei;  Lu, Wei
收藏  |  浏览/下载：4/0  |  提交时间：2020/07/01
A Small-Molecule Compound Selectively Activates K2P Channel TASK-3 by Acting at Two Distant Clusters of Residues 期刊论文
MOLECULAR PHARMACOLOGY, 2019, 卷号: 96, 期号: 1, 页码: 26-35
作者:  Tian, Fuyun;  Qiu, Yunguang;  Lan, Xi;  Li, Min;  Yang, Huaiyu
收藏  |  浏览/下载：18/0  |  提交时间：2020/07/01
Silver-mediated synthesis of novel 3-CF3/CN/phosphonate-substituted pyrazoles as pyrrolomycin analogues from 3-formylchromones and diazo compounds 期刊论文
ORGANIC CHEMISTRY FRONTIERS, 2019, 卷号: 6, 期号: 11, 页码: 1775-1779
作者:  Peng, Xiaofeng;  Zhang, Xiaofei;  Li, Shunyao;  Lu, Yunfu;  Lan, Lefu
收藏  |  浏览/下载：19/0  |  提交时间：2020/07/01
Palladium-Catalyzed Direct Approach to alpha-Trifluoromethyl Alcohols by Selective Hydroxylfluorination of gem-Difluoroalkenes 期刊论文
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2018, 期号: 36, 页码: 5007-5015
作者:  Zhang, Bin;  Zhang, Xiaofei;  Hao, Jian;  Yang, Chunhao
收藏  |  浏览/下载：26/0  |  提交时间：2019/01/08
Discovery of clinical candidate methyl (5-(6-((4(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinopyrrolo[2,1-f][1,2,4]triazin-2-yl)-4-(trifluoromethyl)pyridin-2-yl)carbamate (CYH33) : A highly potent and selective PI3K alpha inhibitor for the treatment of advanced solid tumors 期刊论文
CANCER RESEARCH, 2018, 卷号: 78, 期号: 13, 页码: 2
作者:  Xiang, Haoyue;  Wang, Xiang;  Chen, Yanhong;  Zhang, Xi;  Chen, Yi
收藏  |  浏览/下载：3/0  |  提交时间：2020/07/01

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