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科研机构
上海药物研究所 [45]
内容类型
期刊论文 [43]
会议论文 [2]
发表日期
2021 [3]
2020 [2]
2019 [3]
2018 [4]
2017 [1]
2016 [6]
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Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein
期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 页码: 11
作者:
Fan, Shijie
;
Yue, Liyan
;
Wan, Wei
;
Zhang, Yuanyuan
;
Zhang, Bidong
收藏
  |  
浏览/下载:81/0
  |  
提交时间:2021/12/16
covalent modification
probes
proteome
LC3
post-translational modification
Activating Adenosine Monophosphate-Activated Protein Kinase Mediates Fibroblast Growth Factor 1 Protection From Nonalcoholic Fatty Liver Disease in Mice
期刊论文
HEPATOLOGY, 2021, 卷号: 73, 期号: 6, 页码: 2206-2222
作者:
Lin, Qian
;
Huang, Zhifeng
;
Cai, Genxiang
;
Fan, Xia
;
Yan, Xiaoqing
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2021/08/17
From Design to Clinic: Engineered Nanobiomaterials for Immune Normalization Therapy of Cancer
期刊论文
ADVANCED MATERIALS, 2021, 页码: 37
作者:
Saeed, Madiha
;
Chen, Fangming
;
Ye, Jiayi
;
Shi, Yang
;
Lammers, Twan
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2021/08/17
clinical translation
nanobiomaterials
nanovaccines
normalization cancer immunotherapy
primary and adaptive resistance
tumor immune microenvironment
Anti-PD-L1 mediating tumor-targeted codelivery of liposomal irinotecan/JQ1 for chemo-immunotherapy
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 8
作者:
He, Zhi-di
;
Zhang, Meng
;
Wang, Yong-hui
;
He, Yang
;
Wang, Hai-rui
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2021/05/24
tumor-targeted delivery
immunogenic cell death
PD-1
PD-L1 blockade
tumor immune microenvironment
irinotecan
JQ1
immune checkpoint
Allosteric Regulation of Hsp90 alpha's Activity by Small Molecules Targeting the Middle Domain of the Chaperone
期刊论文
ISCIENCE, 2020, 卷号: 23, 期号: 2, 页码: 46
作者:
Zhou, Chen
;
Zhang, Chi
;
Zhu, Hongwen
;
Liu, Zhijun
;
Su, Haixia
收藏
  |  
浏览/下载:146/0
  |  
提交时间:2020/07/01
USP9X stabilizes BRCA1 and confers resistance to DNA-damaging agents in human cancer cells
期刊论文
CANCER MEDICINE, 2019, 卷号: 8, 期号: 15, 页码: 6730-6740
作者:
Lu, Qin
;
Zhang, Fang-Lin
;
Lu, Da-Yun
;
Shao, Zhi-Ming
;
Li, Da-Qiang
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2020/07/01
BRCA1
breast cancer
deubiquitinase
PARP inhibitor
USP9X
Inhibition of G9a by a small molecule inhibitor, UNC0642, induces apoptosis of human bladder cancer cells
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 8, 页码: 1076-1084
作者:
Cao, Yue-peng
;
Sun, Jing-ya
;
Li, Mei-qian
;
Dong, Yu
;
Zhang, Yuan-heng
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  |  
浏览/下载:18/0
  |  
提交时间:2020/07/01
human urinary bladder cancer
G9a
UNC0642
apoptosis
inhibitionofg9abyasmallmoleculeinhibitorunc0642inducesapoptosisofhumanbladdercancercells
期刊论文
actapharmacologicasinica, 2019, 卷号: 40, 期号: 8, 页码: 1076
作者:
Cao Yuepeng
;
Sun Jingya
;
Li Meiqian
;
Dong Yu
;
Zhang Yuanheng
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2020/07/01
METHYLATION
BIX-01294
PROLIFERATION
SURVIVAL
EHMT2
P53
human urinary bladder cancer
G9a
UNC0642
apoptosis
Sphk2 RNAi nanoparticles suppress tumor growth via downregulating cancer cell derived exosomal microRNA
期刊论文
JOURNAL OF CONTROLLED RELEASE, 2018, 卷号: 286, 页码: 348-357
作者:
Liang, Jinying
;
Zhang, Xinxin
;
He, Shufang
;
Miao, Yunqiu
;
Wu, Na
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2019/01/08
Exosomal miRNA
Sphk2
siRNA silencing
Nanoparticle
HCC therapy
Development of a high-throughput fluorescence polarization assay for the discovery of EZH2-EED interaction inhibitors
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 2, 页码: 302-310
作者:
Zhu, Mao-rong
;
Du, Dao-hai
;
Hu, Jun-chi
;
Li, Lian-chun
;
Liu, Jing-qiu
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2019/01/08
PRC2
EZH2
EED
protein-protein interaction
fluorescence polarization
high-throughput screening
apomorphine hydrochloride
oxyphenbutazone
nifedipine
ergonovine maleate
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