From Design to Clinic: Engineered Nanobiomaterials for Immune Normalization Therapy of Cancer

doi:10.1002/adma.202008094

	From Design to Clinic: Engineered Nanobiomaterials for Immune Normalization Therapy of Cancer
	Saeed, Madiha 1,2; Chen, Fangming 1,2; Ye, Jiayi 1,2; Shi, Yang 3,4; Lammers, Twan 3,4; De Geest, Bruno G.5,6; Xu, Zhi Ping 7; Yu, Haijun 1,2
刊名	ADVANCED MATERIALS
	2021-05-28
页码	37
关键词	clinical translation nanobiomaterials nanovaccines normalization cancer immunotherapy primary and adaptive resistance tumor immune microenvironment
ISSN号	0935-9648
DOI	10.1002/adma.202008094
通讯作者	Yu, Haijun(hjyu@simm.ac.cn)
英文摘要	The tumor immune microenvironment (TIME) is comprised of a complex milieu that contributes to stunting antitumor immune responses by restricting T cells to accumulate in the vicinity of the tumor. Nanomedicine-based strategies are being proposed as a salvage effort to reinvigorate antitumor immunity. Various strategies, however, often fail to unleash the antitumor immune response because of the paucity of appropriate therapeutic targets in the complex TIME, invigorating a fervor of investigation into mechanisms underlying the TIME to resist nanomedicines. In this review article, effective nano/biomaterial-based delivery and TIME normalization approaches that promote T cell-mediated antitumor immune response will be discussed, with a focus on emerging preclinical and clinical strategies for immune normalization. Based on currently available evidence, it seems as if the ultimate success of cancer immunotherapy and nanomedicine hinges on the capacity to normalize the TIME. Here, how nanomedicines target immunosuppressive cells and signaling pathways to broaden the impact of cancer immunotherapy are explored. Acquisition of the urgently needed knowledge of nanomedicine-mediated immune normalization will guide researchers and scientists towards clinical applications of cancer immunotherapy.
资助项目	National Natural Science Foundation of China[32050410287] ; National Natural Science Foundation of China[51873228] ; CAS President's International Fellowship Initiative Program[2019PB0023] ; International Cooperation Project of Science and Technology Commission of Shanghai Municipality[20430711800] ; Youth Innovation Promotion Association of CAS[2014218] ; Open Fund of the State Key Laboratory of Drug Research[SIMM2004KF-04]
WOS关键词	TUMOR-ASSOCIATED MACROPHAGES ; IMMUNOGENIC CELL-DEATH ; HEMATOPOIETIC STEM-CELLS ; SMALL INTERFERING RNA ; EXTRACELLULAR-MATRIX ; CHECKPOINT BLOCKADE ; ANTIANGIOGENIC THERAPY ; VESSEL NORMALIZATION ; IN-VIVO ; NANOPARTICLES
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000655690600001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/297205]
专题	中国科学院上海药物研究所
通讯作者	Yu, Haijun
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, 501 Haike Rd, Shanghai 201203, Peoples R China 3.Rhein Westfal TH Aachen, Dept Nanomed & Theranost, Inst Expt Mol Imaging, Fac Med,Uniklin RWTH Aachen, D-52074 Aachen, Germany 4.Rhein Westfal TH Aachen, Fac Med, Helmholtz Inst Biomed Engn, D-52074 Aachen, Germany 5.Univ Ghent, Dept Pharmaceut, B-9000 Ghent, Belgium 6.Univ Ghent, Canc Res Inst Ghent CRIG, B-9000 Ghent, Belgium 7.Univ Queensland, Australian Inst Bioengn & Nanotechnol, St Lucia, Qld 4072, Australia
推荐引用方式 GB/T 7714	Saeed, Madiha,Chen, Fangming,Ye, Jiayi,et al. From Design to Clinic: Engineered Nanobiomaterials for Immune Normalization Therapy of Cancer[J]. ADVANCED MATERIALS,2021:37.
APA	Saeed, Madiha.,Chen, Fangming.,Ye, Jiayi.,Shi, Yang.,Lammers, Twan.,...&Yu, Haijun.(2021).From Design to Clinic: Engineered Nanobiomaterials for Immune Normalization Therapy of Cancer.ADVANCED MATERIALS,37.
MLA	Saeed, Madiha,et al."From Design to Clinic: Engineered Nanobiomaterials for Immune Normalization Therapy of Cancer".ADVANCED MATERIALS (2021):37.