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科研机构
上海药物研究所 [14]
内容类型
期刊论文 [14]
发表日期
2021 [2]
2020 [2]
2019 [1]
2018 [2]
2015 [1]
2014 [2]
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Triptolide analog LLDT-8 ameliorates psoriasis-like dermatitis in BALB/c mice via suppressing the IL-36 alpha signaling pathway
期刊论文
PHARMACOLOGICAL RESEARCH, 2021, 卷号: 169, 页码: 11
作者:
Qi, Qing
;
Li, Qian
;
Zhu, Hongwen
;
Lu, Huimin
;
Yang, Xiaoqian
收藏
  |  
浏览/下载:71/0
  |  
提交时间:2021/08/17
Triptolide
LLDT-8
Psoriasis
IL-36 alpha
IL-36 alpha pathway
Inflammation
Design, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 211, 页码: 20
作者:
Zhang, Rui
;
Li, Heng
;
Zhang, Xianglei
;
Li, Jian
;
Su, Haixia
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2021/05/24
PDE4 inhibitors
Tetrahydroisoquinoline
Antipsoriasis
DC591017, a phosphodiesterase-4 (PDE4) inhibitor with robust anti-inflammation through regulating PKA-CREB signaling
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2020, 卷号: 177, 页码: 15
作者:
Li, Heng
;
Li, Jian
;
Zhang, Xianglei
;
Feng, Chunlan
;
Fan, Chen
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2020/12/24
DC591017
PDE4
Inflammation
Macrophages
Dendritic cells
Psoriasis
DC591017, a phosphodiesterase-4 (PDE4) inhibitor with robust anti-inflammation through regulating PKA-CREB signaling
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2020, 卷号: 177, 页码: 15
作者:
Li, Heng
;
Li, Jian
;
Zhang, Xianglei
;
Feng, Chunlan
;
Fan, Chen
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2020/12/24
DC591017
PDE4
Inflammation
Macrophages
Dendritic cells
Psoriasis
DZ2002 ameliorates fibrosis, inflammation, and vasculopathy in experimental systemic sclerosis models
期刊论文
ARTHRITIS RESEARCH & THERAPY, 2019, 卷号: 21, 期号: 1, 页码: 15
作者:
Zhang, Zongwang
;
Wu, Yanwei
;
Wu, Bing
;
Qi, Qing
;
Li, Heng
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/07/01
Systemic sclerosis
SAHH inhibitor
Fibrosis
Inflammation
Vasculopathy
TGF-beta
The proteomic study of serially passaged human skin fibroblast cells uncovers down-regulation of the chromosome condensin complex proteins involved in replicative senescence
期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 卷号: 505, 期号: 4, 页码: 1112-1120
作者:
Meng, Qian
;
Gao, Jing
;
Zhu, Hongwen
;
He, Han
;
Lu, Zhi
收藏
  |  
浏览/下载:100/0
  |  
提交时间:2019/01/08
Proteomics
Replicative senescence
Human skin fibroblast cells
SMC2
SMC4
Topical administration of reversible SAHH inhibitor ameliorates imiquimod-induced psoriasis-like skin lesions in mice via suppression of TNF-alpha/IFN-gamma-induced inflammatory response in keratinocytes and T cell-derived IL-17
期刊论文
PHARMACOLOGICAL RESEARCH, 2018, 卷号: 129, 页码: 443-452
作者:
Lin, Ze-Min
;
Ma, Meng
;
Li, Heng
;
Qi, Qing
;
Liu, Yu-Ting
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2019/01/08
Reversible S-adenosyl-L-homocysteine
hydrolase inhibitor
Keratinocyte
Inflammation
Interleukin-17
Imiquimod
Psoriasis
Microneedle-assisted dendritic cell-targeted nanoparticles for transcutaneous DNA immunization
期刊论文
POLYMER CHEMISTRY, 2015, 卷号: 6, 期号: 3, 页码: 373-379
作者:
Hu, Ying
;
Xu, Beihua
;
Xu, Jiaojiao
;
Shou, Dan
;
Liu, Ergang
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/01/08
Comprehensive profiling of lysine acetylome in Staphylococcus aureus
期刊论文
SCIENCE CHINA-CHEMISTRY, 2014, 卷号: 57, 期号: 5, 页码: 732-738
作者:
Zhang Yi
;
Wu ZhiXiang
;
Wan XueLian
;
Liu Ping
;
Zhang JiBao
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
proteomics
post-translational modification
acetylation
Staphylococcus aureus
comprehensiveprofilingoflysineacetylomeinstaphylococcusaureus
期刊论文
sciencechinachemistry, 2014, 卷号: 57, 期号: 5, 页码: 732
作者:
Zhang Yi
;
Wu Zhixiang
;
Wan Xuelian
;
Liu Ping
;
Zhang Jibao
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2020/07/01
LARGE GENE LISTS
CHROMATIN MODIFICATIONS
METABOLIC ENZYMES
ESCHERICHIA-COLI
ACETYLATION
IDENTIFICATION
PROTEINS
DATABASE
REVEALS
proteomics
post-translational modification
acetylation
Staphylococcus aureus
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