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科研机构
上海药物研究所 [14]
内容类型
期刊论文 [14]
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2021 [1]
2019 [2]
2017 [2]
2016 [2]
2015 [2]
2014 [1]
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Anti-DLBCL efficacy of DCZ0825 in vitro and in vivo: involvement of the PI3K-AKT-mTOR/JNK pathway
期刊论文
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2021, 卷号: 53, 期号: 5, 页码: 575-583
作者:
Hu, Ke
;
Li, Bo
;
Ma, Ruye
;
Yi, Hongfei
;
Xu, Zhijian
收藏
  |  
浏览/下载:69/0
  |  
提交时间:2021/06/11
caspase
cell proliferation
cell cycle arrest
diffuse large B-cell lymphoma
PI3K-AKT-mTOR/JNK pathway
DCZ0801, a novel compound, induces cell apoptosis and cell cycle arrest via MAPK pathway in multiple myeloma
期刊论文
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2019, 卷号: 51, 期号: 5, 页码: 517-523
作者:
Zhang, Ting
;
Li, Bo
;
Feng, Qilin
;
Xu, Zhijian
;
Huang, Cheng
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2020/07/01
DCZ0801
multiple myeloma
apoptosis
cell cycle
MAPK
dcz0801anovelcompoundinducescellapoptosisandcellcyclearrestviamapkpathwayinmultiplemyeloma
期刊论文
actabiochimicaetbiophysicasinica, 2019, 卷号: 51, 期号: 5, 页码: 517
作者:
Zhang Ting
;
Li Bo
;
Feng Qilin
;
Xu Zhijian
;
Huang Cheng
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/07/01
IN-VITRO
PTEROSTILBENE
CANCER
PROLIFERATION
P38
ACTIVATION
INDUCTION
SURVIVAL
ERK1/2
DCZ0801
multiple myeloma
apoptosis
cell cycle
MAPK
Dissociative role for dorsal hippocampus in mediating heroin self-administration and relapse through CDK5 and RhoB signaling revealed by proteomic analysis
期刊论文
ADDICTION BIOLOGY, 2017, 卷号: 22, 期号: 6, 页码: 1731-1742
作者:
Chen, Zhong-Guo
;
Liu, Xing
;
Wang, Weisheng
;
Geng, Fan
;
Gao, Jing
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2019/01/08
CDK5
dorsal hippocampus
heroin self-administration
label-free proteomic analysis
RhoB
the centrifugal proteomic reactor
Development of Selective Cyclin-Dependent Kinase 4 Inhibitors for Antineoplastic Therapies
期刊论文
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2017, 卷号: 17, 期号: 5, 页码: 646-657
作者:
Guan, Haixing
;
Du, Yongli
;
Han, Weiwei
;
Shen, Jingkang
;
Li, Qunyi
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/01/08
Anti-cancer agents
cell cycle
clinical trials
cyclin-dependent kinases 4
selective inhibitors
structure activity relationship (SAR)
An Update on Poly(ADP-ribose)polymerase-1 (PARP-1) Inhibitors: Opportunities and Challenges in Cancer Therapy
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 59, 期号: 21, 页码: 9575-9598
作者:
Wang, Ying-Qing
;
Wang, Ping-Yuan
;
Wang, Yu-Ting
;
Yang, Guang-Fu
;
Zhang, Ao
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
Molecular regulation of apoptotic machinery and lipid metabolism by mTORC1/mTORC2 dual inhibitors in preclinical models of HER2+/PIK3CAmut breast cancer
期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 41, 页码: 67071-67086
作者:
Qian, Jianchang
;
Chen, Yaqing
;
Meng, Tao
;
Ma, Lanping
;
Meng, Lanfang
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2019/01/08
mTOR kinase inhibitor
mTORC2
apoptosis
lipid metabolism
A new arylbenzofuran derivative functions as an anti-tumour agent by inducing DNA damage and inhibiting PARP activity
期刊论文
SCIENTIFIC REPORTS, 2015, 卷号: 5
作者:
Chen, Hongbo
;
Zeng, Xiaobin
;
Gao, Chunmei
;
Ming, Pinghong
;
Zhang, Jianping
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/01/08
A beta regulation-based multitarget strategy for drug discovery against Alzheimer's disease
期刊论文
REVIEWS IN THE NEUROSCIENCES, 2015, 卷号: 26, 期号: 1, 页码: 13-30
作者:
Guo, Xiaodan
;
Jiang, Wei
;
Li, Chenjing
;
Zhu, Zhiyuan
;
Shen, Xu
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/01/08
acetyl cholinesterase
Alzheimer's disease
autophagy
beta-amyloid
ER stress
lifespan
multitarget
oxidative stress
secretase
tau protein
CAMK1 Phosphoinositide Signal-Mediated Protein Sorting and Transport Network in Human Hepatocellular Carcinoma (HCC) by Biocomputation
期刊论文
CELL BIOCHEMISTRY AND BIOPHYSICS, 2014, 卷号: 70, 期号: 2, 页码: 1011-1016
作者:
Wang, Lin
;
Huang, Juxiang
;
Jiang, Minghu
;
Chen, Qingchun
;
Jiang, Zhenfu
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2019/01/08
CAMK1
Human hepatocellular carcinoma (HCC)
Phosphoinositide signal-mediated protein sorting and transport network
Biocomputation
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