dcz0801anovelcompoundinducescellapoptosisandcellcyclearrestviamapkpathwayinmultiplemyeloma

doi:10.1093/abbs/gmz033

	dcz0801anovelcompoundinducescellapoptosisandcellcyclearrestviamapkpathwayinmultiplemyeloma
	Zhang Ting 1; Li Bo 2; Feng Qilin 1; Xu Zhijian 2; Huang Cheng 1; Wu Huiqun 1; Chen Zhangbo 1; Hu Liangning 1; Gao Lu 1; Liu Peng 2
刊名	actabiochimicaetbiophysicasinica
	2019
卷号	51 期号:5 页码:517
关键词	IN-VITRO PTEROSTILBENE CANCER PROLIFERATION P38 ACTIVATION INDUCTION SURVIVAL ERK1/2 DCZ0801 multiple myeloma apoptosis cell cycle MAPK
ISSN号	1672-9145
DOI	10.1093/abbs/gmz033
英文摘要	Multiple myeloma (MM) is a refractory malignant hematological malignancy, and many therapeutic strategies have been developed to cure patients with MM. DCZ0801 is a compound that consists of oxophenamide and pterostilbene. The role of these compounds in hematological cancers such as MM has yet to be studied. In this study, we explored the potential mechanism of DCZ0801 action, its anti-tumor activity both in vitro and in vivo on MM. This study was carried out via cell cycle proliferation assay, apoptotic analysis, western blot analysis, and examination of xenotransplantation model of tumors. The in vitro studies revealed that DCZ0801 could inhibit cell proliferation and induce apoptosis by regulating both caspase-dependent and mitogen-activated protein kinase signaling pathways, inducing S-phase arrest of the cell cycle related to downregulation of CDK2, cyclin-A2, and CDC25A protein expression. The in vivo studies showed that DCZ0801 could significantly reduce the size of the tumors in nude mice. Our results demonstrated that DCZ0801 may emerge as the new therapeutic option for the patient with MM.
资助项目	[National Natural Science Foundation of China] ; [National Science & Technology Major Project 'Key New Drug Creation and Manufacturing Program', China]
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/288161]
专题	中国科学院上海药物研究所
作者单位	1.上海市第十人民医院 2.中国科学院上海药物研究所
推荐引用方式 GB/T 7714	Zhang Ting,Li Bo,Feng Qilin,et al. dcz0801anovelcompoundinducescellapoptosisandcellcyclearrestviamapkpathwayinmultiplemyeloma[J]. actabiochimicaetbiophysicasinica,2019,51(5):517.
APA	Zhang Ting.,Li Bo.,Feng Qilin.,Xu Zhijian.,Huang Cheng.,...&Zhu Weiliang.(2019).dcz0801anovelcompoundinducescellapoptosisandcellcyclearrestviamapkpathwayinmultiplemyeloma.actabiochimicaetbiophysicasinica,51(5),517.
MLA	Zhang Ting,et al."dcz0801anovelcompoundinducescellapoptosisandcellcyclearrestviamapkpathwayinmultiplemyeloma".actabiochimicaetbiophysicasinica 51.5(2019):517.