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科研机构
上海药物研究所 [42]
内容类型
期刊论文 [41]
会议论文 [1]
发表日期
2021 [2]
2020 [7]
2019 [2]
2018 [2]
2017 [3]
2016 [1]
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Absorption, distribution, metabolism, and excretion of [C-14]NBP (3-n-butylphthalide) in rats
期刊论文
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2021, 卷号: 1181, 页码: 9
作者:
Tian, Junjun
;
Lei, Peng
;
He, Yifei
;
Zhang, Ning
;
Ge, Xinyu
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2021/11/04
3-n-butylphthalide (NBP)
[C-14]NBP
Pharmacokinetics
Tissue distribution
Metabolism
Mass balance
Anti-nociceptive, anti-inflammatory and anti-arthritic activities of pregnane glycosides from the root bark of Periploca sepium Bunge
期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2021, 卷号: 265, 页码: 12
作者:
Lin, Ze-min
;
Liu, Yu-ting
;
Huang, Yue-teng
;
Yang, Xiao-qian
;
Zhu, Feng-hua
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2021/05/24
Periploca sepium Bunge
Pregnane glycosides
Anti-nociceptive activity
Anti-inflammatory activity
Anti-arthritic activity
Inflammatory arthritis
Clinical application of pyrrole-hemoglobin adducts as a biomarker of pyrrolizidine alkaloid exposure in humans
期刊论文
ARCHIVES OF TOXICOLOGY, 2020, 页码: 7
作者:
Ma, Jiang
;
Zhang, Wei
;
He, Yisheng
;
Zhu, Lin
;
Zhang, Chunyuan
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2020/12/24
Pyrrolizidine alkaloids
Liver injury
Diagnostic biomarkers
Pyrrole-hemoglobin adducts
Pyrrole-plasma protein adducts
Pharmacokinetics and tissue distribution of remdesivir and its metabolites nucleotide monophosphate, nucleotide triphosphate, and nucleoside in mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 6
作者:
Hu, Wen-juan
;
Chang, Lu
;
Yang, Ying
;
Wang, Xin
;
Xie, Yuan-chao
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2020/12/21
remdesivir
pharmacokinetics
tissue distribution
nucleotide monophosphate
nucleotide triphosphate
nucleoside
Simultaneous determination of sutetinib and its active metabolite sutetinibN-oxide in human plasma by liquid chromatography-tandem mass spectrometry: Evaluation of plasma stability
期刊论文
BIOMEDICAL CHROMATOGRAPHY, 2020, 页码: 9
作者:
Qiu, Yanan
;
Tang, Chongzhuang
;
Li, Ranran
;
Cao, Sumin
;
Zhang, Yuqiang
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2020/12/24
LC-MS
MS
N-oxide
stability
sutetinib
DGAT1 inhibitors protect pancreatic beta-cells from palmitic acid-induced apoptosis
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 8
作者:
Huang, Jun-shang
;
Guo, Bin-bin
;
Wang, Gai-hong
;
Zeng, Li-min
;
Hu, You-hong
收藏
  |  
浏览/下载:57/0
  |  
提交时间:2020/12/24
type 2 diabetes
DGAT1 inhibitors
pancreatic beta-cells
apoptosis
ER stress
inflammation
A proton-coupled organic cation antiporter is involved in the blood-brain barrier transport of Aconitum alkaloids
期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2020, 卷号: 252, 页码: 9
作者:
Cong, Jiaojiao
;
Ruan, Yiling
;
Lyu, Qinglin
;
Qin, Xiaohui
;
Qi, Xinming
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/07/01
Aconitum alkaloids
Blood-brain barrier
Proton-coupled organic cation antiporter
hCMEC/D3 cells
Drug transport
The Nonclinical Pharmacokinetics and Prediction of Human Pharmacokinetics of SPH3127, a Novel Direct Renin Inhibitor
期刊论文
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2020, 卷号: 45, 期号: 1, 页码: 15-26
作者:
Zhang, Leduo
;
Mao, Yu
;
Gao, Zhiwei
;
Chen, Xiaoyan
;
Li, Xin
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2020/07/01
Preparation and evaluation of PEGylated asiatic acid nanostructured lipid carriers on anti-fibrosis effects
期刊论文
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2020, 卷号: 46, 期号: 1, 页码: 57-69
作者:
Chen, Xiaoxiao
;
Zhang, Yawen
;
Zhao, Pengfei
;
Chen, Yan
;
Zhou, Yunli
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2020/07/01
Asiatic acid
PEGylated nanostructured lipid carriers
anti-liver fibrosis
liver targeting strategy
pharmacokinetics
Cancer Cell Membrane-Camouflaged Nanorods with Endoplasmic Reticulum Targeting for Improved Antitumor Therapy
期刊论文
ACS APPLIED MATERIALS & INTERFACES, 2019, 卷号: 11, 期号: 50, 页码: 46614-46625
作者:
Zhang, Wei
;
Yu, Miaorong
;
Xi, Ziyue
;
Nie, Di
;
Dai, Zhuo
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2020/07/01
rod shape
endoplasmic reticulum-tatgeted
cancer cell membrane coating
intracellular trafficking
pancreatic tumor delivery
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