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科研机构
上海药物研究所 [22]
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期刊论文 [22]
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2021 [2]
2020 [1]
2019 [1]
2018 [2]
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Exploring biological basis of Syndrome differentiation in coronary heart disease patients with two distinct Syndromes by integrated multi-omics and network pharmacology strategy
期刊论文
Chinese Medicine, 2021, 卷号: 16, 期号: 1
作者:
Wu,Gaosong
;
Zhao,Jing
;
Zhao,Jing
;
Song,Nixue
;
Zheng,Ningning
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2021/12/01
Coronary heart disease
Syndrome differentiation
Traditional Chinese Medicine
Proteomics
Metabolomics
Network pharmacology
Structural basis of ketamine action on human NMDA receptors
期刊论文
NATURE, 2021, 卷号: 596, 期号: 7871, 页码: 301-+
作者:
Zhang, Youyi
;
Ye, Fei
;
Zhang, Tongtong
;
Lv, Shiyun
;
Zhou, Liping
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2021/11/04
Antiepileptic geissoschizine methyl ether is an inhibitor of multiple neuronal channels
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 9
作者:
Xie, Zhu-qing
;
Tian, Xiao-ting
;
Zheng, Yue-ming
;
Zhan, Li
;
Chen, Xue-qin
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2020/07/01
geissoschizine methyl ether
Uncaria rhynchophyll
antiepileptic drug
hippocampal neurons
action potential
nicotinic acetylcholine receptors
voltage-gated ion channels
mouse seizure model
Metabolic characterization of diabetic retinopathy: An H-1-NMR-based metabolomic approach using human aqueous humor
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2019, 卷号: 174, 页码: 414-421
作者:
Jin, Huiyi
;
Zhu, Bijun
;
Liu, Xia
;
Jin, Jing
;
Zou, Haidong
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2020/07/01
Metabolomics
NMR analysis
Aqueous humor
Diabetic retinopathy
Metabolite-metabolite correlation
Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors
期刊论文
Cell reports, 2018, 卷号: 25, 期号: 13, 页码: 3582-3590.e4
作者:
Zhang, Jin-Bao
;
Chang, Shenghai
;
Xu, Pan
;
Miao, Miao
;
Wu, Hangjun
收藏
  |  
浏览/下载:118/0
  |  
提交时间:2019/01/08
The involvement of Nrf2 antioxidant signalling pathway in the protection of monocrotaline-induced hepatic sinusoidal obstruction syndrome in rats by (+)-catechin hydrate
期刊论文
Free radical research, 2018, 卷号: 52, 期号: 4, 页码: 402-414
作者:
Jing, Xiaoqi
;
Zhang, Jiaqi
;
Huang, Zhenlin
;
Sheng, Yuchen
;
Ji, Lili
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/01/08
Metabolomics study on the antitumor effect of marine natural compound flexibilide in HCT-116 colon cancer cell line
期刊论文
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2016, 卷号: 1014, 页码: 17-23
作者:
Gao, Dan
;
Wang, Yini
;
Xie, Weiyi
;
Yang, Ti
;
Jiang, Yuyang
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
Metabolomics
UPLC/Q-TOF MS
Flexibilide
HCT-116 cells
Action mechanism
Metabolism by conjugation appears to confer resistance to paracetamol (acetaminophen) hepatotoxicity in the cynomolgus monkey
期刊论文
XENOBIOTICA, 2015, 卷号: 45, 期号: 3, 页码: 270-277
作者:
Yu, Hong
;
Barrass, Nigel
;
Gales, Sonya
;
Lenz, Eva
;
Parry, Tony
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2019/01/08
Cynomolgus monkeys
detoxification by glucuronidation
paracetamol toxicity
Positive allosteric modulators to peptide GPCRs: a promising class of drugs
期刊论文
ACTA PHARMACOLOGICA SINICA, 2013, 卷号: 34, 期号: 7, 页码: 880-885
作者:
Bartfai, Tamas
;
Wang, Ming-wei
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
neuropeptide
galanin
GPCR
allosteric mudulation
CYM2503
anticonvulsant
drug screening
Novel glycine-dependent inactivation of NMDA receptors in cultured hippocampal neurons
期刊论文
NEUROSCIENCE BULLETIN, 2012, 卷号: 28, 期号: 5, 页码: 550
作者:
Zhang YunFeng
;
Li Xia
;
Peng LiangLiang
;
Wang GuoHua
;
Ke KaiFu
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2020/12/24
MOLECULAR DETERMINANTS
INTERNALIZATION
MODULATION
CHANNELS
SUBUNIT
glycine
N-methyl-D-aspartate receptors
calcium imaging
NMDA-NR1 subunit
hippocampal neurons
inactivation
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