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科研机构
上海药物研究所 [23]
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期刊论文 [23]
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2021 [2]
2020 [2]
2019 [2]
2018 [3]
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Novel tetrahydrobenzo[b]thiophen-2-yl)urea derivatives as novel alpha-glucosidase inhibitors: Synthesis, kinetics study, molecular docking, and in vivo anti-hyperglycemic evaluation
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 115, 页码: 17
作者:
Xie, Hong-Xu
;
Zhang, Juan
;
Li, Yue
;
Zhang, Jin-He
;
Liu, Shan-Kui
收藏
  |  
浏览/下载:69/0
  |  
提交时间:2021/11/04
Tetrahydrobenzo[b]thiophen-2-yl)urea
alpha-Glucosidase inhibitors
Non-competitive inhibitor
Molecular docking
Anti-hyperglycaemic activity
Type 2 diabetes
Identification of novel anti-inflammatory Nur77 modulators by virtual screening
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 112, 页码: 7
作者:
Ding, Xiaoyu
;
Zhao, Zijie
;
Wu, Yue
;
Zhang, Hao
;
Chen, Kaixian
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2021/08/17
Nur77
Binding site evaluation
Virtual Screening
Inflammation
23,24-Dihydrocucurbitacin B promotes lipid clearance by dual transcriptional regulation of LDLR and PCSK9
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 卷号: 41, 期号: 3, 页码: 327-335
作者:
Li, Hui-hui
;
Li, Jun
;
Zhang, Xian-jing
;
Li, Jiao-meng
;
Xi, Cong
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2020/07/01
23,24-dihydrocucurbitacin B
lipid-lowering agent
LDLR
PCSK9
HNF1 alpha
SREBP2
2324dihydrocucurbitacinbpromoteslipidclearancebydualtranscriptionalregulationofldlrandpcsk9
期刊论文
actapharmacologicasinica, 2020, 卷号: 41, 期号: 3, 页码: 327
作者:
Li Huihui
;
Li Jun
;
Zhang Xianjing
;
Li Jiaomeng
;
Xi Cong
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2020/07/01
23
24-dihydrocucurbitacin B
lipid-lowering agent
LDLR
PCSK9
HNF1α
SREBP2
Antitumor, Antiviral, and Anti-Inflammatory Efficacy of Essential Oils from Atractylodes macrocephala Koidz. Produced with Different Processing Methods
期刊论文
MOLECULES, 2019, 卷号: 24, 期号: 16, 页码: 14
作者:
Gu, Sihao
;
Li, Ling
;
Huang, Hai
;
Wang, Bing
;
Zhang, Tong
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2020/07/01
Atractylodes macrocephala Koidz
essential oils
atractylone
processing methods
GC
MS
pharmacodynamic effect
Design, synthesis, and biological evaluation of novel phenol ether derivatives as non-covalent proteasome inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 161, 页码: 543-558
作者:
Yu, Jianjun
;
Xu, Lei
;
Hong, Duidui
;
Zhang, Xiaotuan
;
Liu, Jieyu
收藏
  |  
浏览/下载:71/0
  |  
提交时间:2019/01/08
Proteasome inhibitor
Non-covalent
Non-peptide
Phenol ether
Solid cancers
Isocryptolepine, an indoloquinoline alkaloid from Cryptolepis sanguinolenta promotes LDL uptake in HepG2 cells
期刊论文
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, 2018, 卷号: 28, 期号: 6, 页码: 654-657
作者:
Aggrey, Mike Okweesi
;
Li, Hui-Hui
;
Wang, Wen-Qiong
;
Song, Weibin
;
Wang, Yiping
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2019/01/08
Antihyperlipidemia
Atherosclerosis
Dil-LDL uptake
HepG2 cells
lsocryptolepine
SAR
Indole alkaloid from Nauclea latifolia promotes LDL uptake in HepG2 cells by inhibiting PCSK9
期刊论文
Phytomedicine, 2018
作者:
Aggrey, Mike Okweesi
;
Li, Hui-Hui
;
Wang, Wen-Qiong
;
Wang, Yiping
;
Xuan, Li-Jiang
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2019/03/13
Anti-hyperlipidemia
Nauclea Latifolia
Pcsk9
Sar
Indoloquinolizidine Alkaloids
Halimane-type diterpenoids from Vitex rotundifolia and their anti-hyperlipidemia activities
期刊论文
PHYTOCHEMISTRY, 2018, 卷号: 146, 页码: 56-62
作者:
Wang, Wen-qiong
;
Yin, Yan-peng
;
Jun, Li
;
Xuan, Li-jiang
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/01/08
Vitex rotundifolia (verbenaceae)
Diterpenoids
Anti-hyperlipidemia
Marine natural product des-O-methyllasiodiplodin effectively lowers the blood glucose level in db/db mice via ameliorating inflammation
期刊论文
ACTA PHARMACOLOGICA SINICA, 2013, 卷号: 34, 期号: 10, 页码: 1325-1336
作者:
Zhou, Rong
;
Lin, Zhong-hui
;
Jiang, Cheng-shi
;
Gong, Jing-xu
;
Chen, Li-li
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
des-O-methyllasiodiplodin
diabetes
db/db mice
pro-inflammatory cytokine
ROS
mineralocorticoid receptor
aldosterone
blood glucose
glycosylated hemoglobin (HbA1c)
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