Antitumor, Antiviral, and Anti-Inflammatory Efficacy of Essential Oils from Atractylodes macrocephala Koidz. Produced with Different Processing Methods

doi:10.3390/molecules24162956

	Antitumor, Antiviral, and Anti-Inflammatory Efficacy of Essential Oils from Atractylodes macrocephala Koidz. Produced with Different Processing Methods
	Gu, Sihao 2; Li, Ling 2; Huang, Hai 1; Wang, Bing 2,3; Zhang, Tong 2
刊名	MOLECULES
	2019-08-01
卷号	24 期号:16 页码:14
关键词	Atractylodes macrocephala Koidz essential oils atractylone processing methods GC MS pharmacodynamic effect
DOI	10.3390/molecules24162956
通讯作者	Wang, Bing(bwang@simm.ac.cn) ; Zhang, Tong(zhangtdmj@hotmail.com)
英文摘要	Atractylodes macrocephala Koidz. has been used as an invigorating spleen drug for eliminating dampness and phlegm in China. According to recent researches, different processing methods may affect the drug efficacy, so we collected A. macrocephala from the Zhejiang Province, produced with different processing methods, crude A. macrocephala (CA) and bran-processed A. macrocephala (BA), then analyzed its essential oils (EOs) by GC/MS. The results showed 34 components representing 98.44% of the total EOs of CA were identified, and 46 components representing 98.02% of the total EOs of BA were identified. Atractylone is the main component in A. macrocephala. Compared with CA, BA has 46 detected compounds, 28 of which were identical, and 6 undetected compounds. Pharmacodynamic results revealed that the EOs of CA and atractylone exhibited more effective anticancer activity in HepG2, MCG803, and HCT-116 cells than the EOs of BA; while the EOs of BA exhibited simple antiviral effect on viruses H3N2, both the EOs and atractylone show anti-inflammatory activity by inhibiting the lipopolysaccharide (LPS)-induced nitric oxide (NO) production in ANA-1 cells.
资助项目	National Natural Science Foundation of China[2017ZX09201010-014-014] ; Shanghai China Medicine Development Three-Year Action Plan[ZY3-CCXX-3-4001] ; Foundation of the Shanghai Science and Technology Commission[17401902300]
WOS关键词	PERFORMANCE LIQUID-CHROMATOGRAPHY ; CHEMICAL-COMPOSITION ; ATRACTYLENOLIDE-I ; VOLATILE COMPOUNDS ; TIGHT JUNCTIONS ; EXTRACTION ; PHASE ; CONSTITUENTS ; COMPONENTS ; RHIZOMA
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	MDPI
WOS记录号	WOS:000482998900009
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/288779]
专题	中国科学院上海药物研究所
通讯作者	Wang, Bing; Zhang, Tong
作者单位	1.Fudan Univ, Sch Pharm, Expt Teaching Ctr Pharmaceut Sci, 826 Zhang Heng Rd, Shanghai 201203, Peoples R China 2.Shanghai Univ Tradit Chinese Med, Sch Pharm, Expt Ctr Teaching & Learning, 1200 Cai Lun Rd, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Materia Med, Ctr Pharmaceut Res, 501 Hai Ke Rd, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Gu, Sihao,Li, Ling,Huang, Hai,et al. Antitumor, Antiviral, and Anti-Inflammatory Efficacy of Essential Oils from Atractylodes macrocephala Koidz. Produced with Different Processing Methods[J]. MOLECULES,2019,24(16):14.
APA	Gu, Sihao,Li, Ling,Huang, Hai,Wang, Bing,&Zhang, Tong.(2019).Antitumor, Antiviral, and Anti-Inflammatory Efficacy of Essential Oils from Atractylodes macrocephala Koidz. Produced with Different Processing Methods.MOLECULES,24(16),14.
MLA	Gu, Sihao,et al."Antitumor, Antiviral, and Anti-Inflammatory Efficacy of Essential Oils from Atractylodes macrocephala Koidz. Produced with Different Processing Methods".MOLECULES 24.16(2019):14.