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科研机构
上海药物研究所 [13]
内容类型
期刊论文 [13]
发表日期
2018 [1]
2017 [1]
2016 [2]
2015 [2]
2014 [3]
2013 [2]
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Inhibition of dengue viral infection by diasarone-I is associated with 2'O methyltransferase of NS5
期刊论文
EUROPEAN JOURNAL OF PHARMACOLOGY, 2018, 卷号: 821, 页码: 11-20
作者:
Yao, Xingang
;
Ling, Yun
;
Guo, Songxin
;
He, Shijun
;
Wang, Jinan
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2019/01/08
DENV2
Acorus tatarinowii Schott
Diasarone-I
2'O
methyltransferase
The Second-generation of Highly Potent Hepatitis C Virus (HCV) NS3/4A Protease Inhibitors: Evolutionary Design Based on Tailor-made Amino Acids, Synthesis and Major Features of Bio-activity
期刊论文
CURRENT PHARMACEUTICAL DESIGN, 2017, 卷号: 23, 期号: 30, 页码: 4493-4554
作者:
Wang, Shuni
;
Wang, Yibing
;
Wang, Jiang
;
Sato, Tatsunori
;
Izawa, Kunisuke
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2019/01/08
Hepatitis C virus (HCV)
pandemic
direct-acting antiviral agents (DAAs)
NS3/4A protease inhibitor
tailor-made amino acids
structure-activity relationship (SAR)
asymmetric synthesis
ring-closing metathesis (RCM)
Tailor-Made alpha-Amino Acids in the Pharmaceutical Industry: Synthetic Approaches to (1R,2S)-1-Amino-2-vinylcyclopropane-1-carboxylic Acid (Vinyl-ACCA)
期刊论文
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2016, 期号: 16, 页码: 2757-2774
作者:
Sato, Tatsunori
;
Izawa, Kunisuke
;
Luis Acena, Jose
;
Liu, Hong
;
Soloshonok, Vadim A.
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
Asymmetric synthesis
Amino acids
Medicinal chemistry
Drug design
Antiviral agents
Advanced asymmetric synthesis of (1R,2S)-1-amino-2-vinylcyclopropanecarboxylic acid by alkylation/cyclization of newly designed axially chiral Ni(II) complex of glycine Schiff base
期刊论文
AMINO ACIDS, 2016, 卷号: 48, 期号: 4, 页码: 973-986
作者:
Kawashima, Aki
;
Shu, Shuangjie
;
Takeda, Ryosuke
;
Kawamura, Akie
;
Sato, Tatsunori
收藏
  |  
浏览/下载:95/0
  |  
提交时间:2019/01/08
Anti-viral (HCV) activity
Asymmetric synthesis
Amino acids
Chirality
Schiff bases
Policresulen, a novel NS2B/NS3 protease inhibitor, effectively inhibits the replication of DENV2 virus in BHK-21 cells
期刊论文
ACTA PHARMACOLOGICA SINICA, 2015, 卷号: 36, 期号: 9, 页码: 1126-1136
作者:
Wu, Deng-wei
;
Mao, Fei
;
Ye, Yan
;
Li, Jian
;
Xu, Chuan-lian
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/01/08
Dengue virus
antiviral drug
NS2B/NS3 protease
policresulen
molecular docking
molecular modeling
policresulenanovelns2bns3proteaseinhibitoreffectivelyinhibitsthereplicationofdenv2virusinbhk21cells
期刊论文
actapharmacologicasinica, 2015, 卷号: 36, 期号: 9, 页码: 1126
作者:
Wu Dengwei
;
Mao Fei
;
Ye Yan
;
Li Jian
;
Xu Chuanlian
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2020/07/01
SMALL-MOLECULE INHIBITORS
STRUCTURE-BASED DISCOVERY
DRUG-LIKE MOLECULES
DENGUE VIRUS
SERINE-PROTEASE
NS3 PROTEASE
PEPTIDE INHIBITORS
NS2B-NS3 PROTEASE
ACCURATE DOCKING
IN-VITRO
Dengue virus
antiviral drug
NS2B/NS3 protease
policresulen
molecular docking
molecular modeling
Identification of novel thiadiazoloacrylamide analogues as inhibitors of dengue-2 virus NS2B/NS3 protease
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 卷号: 22, 期号: 22, 页码: 6344-6352
作者:
Liu, Hailong
;
Wu, Ruoming
;
Sun, Yanyan
;
Ye, Yan
;
Chen, Jing
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
Thiadiazo
Dengue virus
NS2B/NS3
Discovering novel anti-HCV compounds with inhibitory activities toward HCV NS3/4A protease
期刊论文
ACTA PHARMACOLOGICA SINICA, 2014, 卷号: 35, 期号: 8, 页码: 1074-1081
作者:
Yu, Ye
;
Jing, Jing-feng
;
Tong, Xian-kun
;
He, Pei-lan
;
Li, Yuan-chao
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
hepatitis C virus
NS3/4A protease
secreted embryonic alkaline phosphatase (Seap)
2,4-diaminoquinazoline
carboxamide
telaprevir
discoveringnovelantihcvcompoundswithinhibitoryactivitiestowardhcvns34aprotease
期刊论文
actapharmacologicasinica, 2014, 卷号: 35, 期号: 8, 页码: 1074
作者:
Yu Ye
;
Jing Jingfeng
;
Tong Xiankun
;
He Peilan
;
Li Yuanchao
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2020/07/01
HEPATITIS-C VIRUS
PLUS RIBAVIRIN
REPLICATION
TELAPREVIR
POTENT
EPIDEMIOLOGY
BOCEPREVIR
hepatitis C virus
NS3/4A protease
secreted embryonic alkaline phosphatase (Seap)
2,4-diaminoquinazoline
carboxamide
telaprevir
Identification of Novel Small Molecules as Inhibitors of Hepatitis C Virus by Structure-Based Virtual Screening
期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2013, 卷号: 14, 期号: 11, 页码: 22845-22856
作者:
Li, Jing
;
Liu, Xian
;
Li, Shanshan
;
Wang, Yulan
;
Zhou, Nannan
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/01/08
hepatitis C virus (HCV)
NS3
NS4A serine protease
structure-based drug design (SBDD)
virtual screening
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