policresulenanovelns2bns3proteaseinhibitoreffectivelyinhibitsthereplicationofdenv2virusinbhk21cells

doi:10.1038/aps.2015.56

	policresulenanovelns2bns3proteaseinhibitoreffectivelyinhibitsthereplicationofdenv2virusinbhk21cells
	Wu Dengwei 1; Mao Fei 2; Ye Yan 3; Li Jian 2; Xu Chuanlian 1; Luo Xiaomin 3; Chen Jing 3; Shen Xu 3
刊名	actapharmacologicasinica
	2015
卷号	36 期号:9 页码:1126
关键词	SMALL-MOLECULE INHIBITORS STRUCTURE-BASED DISCOVERY DRUG-LIKE MOLECULES DENGUE VIRUS SERINE-PROTEASE NS3 PROTEASE PEPTIDE INHIBITORS NS2B-NS3 PROTEASE ACCURATE DOCKING IN-VITRO Dengue virus antiviral drug NS2B/NS3 protease policresulen molecular docking molecular modeling
ISSN号	1671-4083
DOI	10.1038/aps.2015.56
英文摘要	Aim: Dengue is a severe epidemic disease caused by dengue virus (DENV) infection, for which no effective treatment is available. The protease complex, consisting of nonstructural protein 3 (NS3) and its cofactor NS2B, plays a pivotal role in the replication of DENV, thus may be a potential target for anti-DENV drugs. Here, we report a novel inhibitor of DENV2 NS2B/NS3 protease and its antiviral action.
资助项目	[National Natural Science Foundation of China]
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/282969]
专题	中国科学院上海药物研究所
作者单位	1.浙江理工大学 2.华东理工大学 3.中国科学院上海药物研究所
推荐引用方式 GB/T 7714	Wu Dengwei,Mao Fei,Ye Yan,et al. policresulenanovelns2bns3proteaseinhibitoreffectivelyinhibitsthereplicationofdenv2virusinbhk21cells[J]. actapharmacologicasinica,2015,36(9):1126.
APA	Wu Dengwei.,Mao Fei.,Ye Yan.,Li Jian.,Xu Chuanlian.,...&Shen Xu.(2015).policresulenanovelns2bns3proteaseinhibitoreffectivelyinhibitsthereplicationofdenv2virusinbhk21cells.actapharmacologicasinica,36(9),1126.
MLA	Wu Dengwei,et al."policresulenanovelns2bns3proteaseinhibitoreffectivelyinhibitsthereplicationofdenv2virusinbhk21cells".actapharmacologicasinica 36.9(2015):1126.