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科研机构
上海药物研究所 [39]
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期刊论文 [39]
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2021 [2]
2020 [3]
2018 [4]
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内容类型:期刊论文
专题:上海药物研究所
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Structural optimization and biological evaluation for novel artemisinin derivatives against liver and ovarian cancers
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 211, 页码: 13
作者:
Zhou, Yu
;
Li, Xiaoguang
;
Chen, Kerong
;
Ba, Qian
;
Zhang, Xu
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2021/06/11
Structural optimization
Lead compound
Artemisinin derivatives
Cancer
Structural optimization and biological evaluation for novel artemisinin derivatives against liver and ovarian cancers
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 211, 页码: 13
作者:
Zhou, Yu
;
Li, Xiaoguang
;
Chen, Kerong
;
Ba, Qian
;
Zhang, Xu
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2021/05/24
Structural optimization
Lead compound
Artemisinin derivatives
Cancer
Anti-proliferative cassane-type diterpenoids from the seeds of Caesalpinia minax
期刊论文
NATURAL PRODUCT RESEARCH, 2020, 页码: 10
作者:
Xu, Yunshao
;
Shi, Wei
;
Feng, Lu
;
Cao, Jun
;
Feng, Zheling
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2021/05/24
Caesalpinia minax
Fabaceae
cassane diterpenoids
cytotoxic activity
An antibody-drug conjugate targeting a GSTA glycosite-signature epitope of MUC1 expressed by non-small cell lung cancer
期刊论文
CANCER MEDICINE, 2020, 页码: 12
作者:
Pan, Deng
;
Tang, Yubo
;
Tong, Jiao
;
Xie, Chengmei
;
Chen, Jiaxi
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  |  
浏览/下载:21/0
  |  
提交时间:2020/12/24
Phase I dose-escalation and expansion study of PARP inhibitor, fluzoparib (SHR3162), in patients with advanced solid tumors
期刊论文
CHINESE JOURNAL OF CANCER RESEARCH, 2020, 卷号: 32, 期号: 3, 页码: 370-+
作者:
Li, Huiping
;
Liu, Rongrui
;
Shao, Bin
;
Ran, Ran
;
Song, Guohong
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2020/12/24
Phase I
PARP inhibitor (fluzoparib)
solid tumor
pharmacokinetics
safety
antitumor activity
Immune modulation of a lipid-soluble extract of Pinellia pedatisecta Schott in the tumor microenvironment of an HPV+ tumor-burdened mouse model
期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2018, 卷号: 225, 页码: 103-115
作者:
Huang, Haixia
;
Zhang, Mingxing
;
Yao, Sheng
;
Zhang, Meng
;
Peng, Jing
收藏
  |  
浏览/下载:72/0
  |  
提交时间:2019/01/08
Pinellia pedatisecta extract (PE)
Cervical cancer
HPV+ tumor
TC-1 cell line
Helper T (Th) cellular immunity
Current Strategies and Applications for Precision Drug Design
期刊论文
FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9
作者:
Wang, Chen
;
Xu, Pan
;
Zhang, Luyu
;
Huang, Jing
;
Zhu, Kongkai
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  |  
浏览/下载:48/0
  |  
提交时间:2019/01/08
precision medicine
precision drug design
computational modeling
deep learning
antibody-drug conjugates
ligand-targeted conjugates
Epitopes of MUC1 Tandem Repeats in Cancer as Revealed by Antibody Crystallography: Toward Glycopeptide Signature-Guided Therapy
期刊论文
MOLECULES, 2018, 卷号: 23, 期号: 6
作者:
Zhou, Dapeng
;
Xu, Lan
;
Huang, Wei
;
Tonn, Torsten
收藏
  |  
浏览/下载:72/0
  |  
提交时间:2019/01/08
MUC1
tandem repeat
antibodies
glycopeptide
co-crystal
Identification and Characterizations of Novel, Selective Histone Methyltransferase SET7 Inhibitors by Scaffold Hopping- and 2D-Molecular Fingerprint-Based Similarity Search
期刊论文
MOLECULES, 2018, 卷号: 23, 期号: 3
作者:
Ding, Hong
;
Lu, Wen Chao
;
Hu, Jun Chi
;
Liu, Yu-Chih
;
Zhang, Chen Hua
收藏
  |  
浏览/下载:52/0
  |  
提交时间:2019/01/08
SET7
inhibitor
similarity search
ligand-based drug design
chemical biology probe
Dihydroartemisinin selectively inhibits PDGFR alpha-positive ovarian cancer growth and metastasis through inducing degradation of PDGFR alpha protein
期刊论文
CELL DISCOVERY, 2017, 卷号: 3
作者:
Li, Xiaoguang
;
Ba, Qian
;
Liu, Yanling
;
Yue, Qingxi
;
Chen, Peizhan
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2019/01/08
Dihydroartemisinin
Epithelial-mesenchymal transition
metastasis
ovarian cancer
PDGFR alpha
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