Anti-proliferative cassane-type diterpenoids from the seeds of Caesalpinia minax

doi:10.1080/14786419.2020.1853729

	Anti-proliferative cassane-type diterpenoids from the seeds of Caesalpinia minax
	Xu, Yunshao 1; Shi, Wei 1; Feng, Lu 2,3; Cao, Jun 1; Feng, Zheling 1; Zhang, Qingwen 1; Lu, Jinjian 1; Ye, Yang 2,3,4; Lin, Ligen 1
刊名	NATURAL PRODUCT RESEARCH
	2020-11-22
页码	10
关键词	Caesalpinia minax Fabaceae cassane diterpenoids cytotoxic activity
ISSN号	1478-6419
DOI	10.1080/14786419.2020.1853729
通讯作者	Lin, Ligen(ligenl@um.edu.mo)
英文摘要	The seeds of Caesalpinia minax Hance have shown anti-tumor potential, while the chemical principle is still unknown. In a search for anti-tumor compounds, six new cassane-type diterpenoids, 12-demethylcaesalpin G (1), caesalpinolide H (2), 12-demethylcaesalpin H (3), caesalpinolide J (4), 12-O-ethyl neocaesalpin B (5), and 3-deacetyldecapetpene B (6), were isolated from the seeds of C. minax Hance, along with fifteen known analogues. The structures of the new compounds were established by means of spectroscopic techniques (NMR, HRESIMS and IR). The absolute configurations of the new compounds were determined by their ECD spectra. All of the new compounds were tested for their anti-proliferative activity against human lung cancer A549 cells, breast cancer MCF-7 cells, and ovarian cancer HEY cells. The results indicated that only compound 6 displayed moderate cytotoxicity against three cancer cell lines. Thus, the opening of furan ring in cassane-type diterpenoids might enhance the cytotoxic activity.
资助项目	University of Macau[MYRG2017-00109-ICMS] ; University of Macau[MYRG2018-00037ICMS] ; National Natural Science Foundation of China[81872754] ; Key-Area Research and Development Program of Guangdong Province, China[2020B1111110003] ; Open Research Fund of Chengdu University of Traditional Chinese Medicine Key Laboratory of Systematic Research of Distinctive Chinese Medicine Resources in Southwest China[2020GZ2011011]
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
出版者	TAYLOR & FRANCIS LTD
WOS记录号	WOS:000596647100001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/296187]
专题	中国科学院上海药物研究所
通讯作者	Lin, Ligen
作者单位	1.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, Shanghai, Peoples R China 4.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Xu, Yunshao,Shi, Wei,Feng, Lu,et al. Anti-proliferative cassane-type diterpenoids from the seeds of Caesalpinia minax[J]. NATURAL PRODUCT RESEARCH,2020:10.
APA	Xu, Yunshao.,Shi, Wei.,Feng, Lu.,Cao, Jun.,Feng, Zheling.,...&Lin, Ligen.(2020).Anti-proliferative cassane-type diterpenoids from the seeds of Caesalpinia minax.NATURAL PRODUCT RESEARCH,10.
MLA	Xu, Yunshao,et al."Anti-proliferative cassane-type diterpenoids from the seeds of Caesalpinia minax".NATURAL PRODUCT RESEARCH (2020):10.