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科研机构
上海药物研究所 [2]
中南大学 [2]
北京大学 [1]
化学研究所 [1]
武汉物理与数学研究所 [1]
高能物理研究所 [1]
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期刊论文 [12]
发表日期
2016 [12]
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Small molecule lx2343 ameliorates cognitive deficits in ad model mice by targeting both amyloid beta production and clearance
期刊论文
Acta pharmacologica sinica, 2016, 卷号: 37, 期号: 10, 页码: 1281-1297
作者:
Guo, Xiao-dan
;
Sun, Guang-long
;
Zhou, Ting-ting
;
Xu, Xin
;
Zhu, Zhi-yuan
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2019/05/09
Alzheimer's disease
N-(1,3-benzodioxol-5-yl)-2-[5-chloro-2-methoxy(phenylsulfonyl)anilino]acetamide (lx2343)
Streptozotocin
Amyloid beta
Pi3k
Autophagy
App/ps1 transgenic mice
Cognitive deficit
Bace1
Small molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both amyloid beta production and clearance
期刊论文
ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 10, 页码: 1281-1297
作者:
Guo, Xiao-dan
;
Sun, Guang-long
;
Zhou, Ting-ting
;
Xu, Xin
;
Zhu, Zhi-yuan
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
Alzheimer's disease
N-(1,3-benzodioxol-5-yl)-2-[5-chloro-2-methoxy(phenylsulfonyl)anilino]acetamide (LX2343)
streptozotocin
amyloid beta
BACE1
PI3K
autophagy
APP/PS1 transgenic mice
cognitive deficit
GENDER DIFFERENCES OF PERIPHERAL PLASMA AND LIVER METABOLIC PROFILING IN APP/PS1 TRANSGENIC AD MICE
期刊论文
NEUROSCIENCE, 2016, 卷号: 332, 页码: 160-169
作者:
Wu, Junfang
;
Fu, Bin
;
Lei, Hehua
;
Tang, Huiru
;
Wang, Yulan
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2016/11/04
Alzheimer's disease
gender difference
metabonomics
peripheral
liver extracts
fatty acids
Alzheimer's disease-associated mutations increase amyloid precursor protein resistance to gamma-secretase cleavage and the A beta 42/A beta 40 ratio
期刊论文
CELL DISCOVERY, 2016, 卷号: 2
作者:
Xu, Ting-Hai
;
Yan, Yan
;
Kang, Yanyong
;
Jiang, Yi
;
Melcher, Karsten
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/01/08
Alzheimer's disease
C99
gamma-secretase
familial Alzheimer disease (FAD)-linked mutations
epsilon-cleavage assay
Kinesin-1 inhibits the aggregation of amyloid-beta peptide as detected by fluorescence cross-correlation spectroscopy
期刊论文
FEBS LETTERS, 2016, 卷号: 590, 期号: 7, 页码: 1028-1037
作者:
Zheng, Yanpeng
;
Tian, Shijun
;
Peng, Xianglei
;
Yang, Jingfa
;
Fu, Yuanhui
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2017/01/23
Alzheimer's disease
amyloid beta
fluorescence cross-correlation spectroscopy
kinesin-1
Fluorescent turn-on determination of the activity of peptidases using peptide templated gold nanoclusters
期刊论文
Microchimica Acta, 2016, 卷号: 183, 期号: 2, 页码: 605-610
作者:
Luo, Junjun
;
Rasooly, Avraham
;
Wang, Liqiang
;
Zeng, Ke
;
Shen, Congcong
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/03
beta-Secretases
APP cleaving enzyme
BACE1
beta-amyloid precursor protein
Transmission electron microscopy
Fluorometry
BACE1 in the retina: a sensitive biomarker for monitoring early pathological changes in Alzheimer's disease
期刊论文
Neural Regeneration Research, 2016, 卷号: 11, 期号: 3, 页码: 447-453
作者:
Lan Li
;
Jia Luo
;
Dan Chen
;
Jian-bin Tong
;
Le-ping Zeng
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/03
nerve
regeneration
neurodegenerative
disease
Alzheimer’s
disease
RETINA
amyloid-β
β-site
amyloid
precursor
protein
cleaving
enzyme
APP/PS-1
transgenic
mouse
neural
regeneration
nerve regeneration neurodegenerative disease Alzheimer's disease retina amyloid-β β-site amyloid precursor protein cleaving enzyme 1 APP/PS-1 transgenic mouse neural regeneration
Yeast Two-Hybrid Screening for Proteins that Interact with the Extracellular Domain of Amyloid Precursor Protein
期刊论文
NEUROSCIENCE BULLETIN, 2016
Yu, You
;
Li, Yinan
;
Zhang, Yan
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2017/12/03
Amyloid precursor protein
Alzheimer&apos
Yeast two-hybrid screening
Cell death
Pelizaeus-Merzbacher disease
PELIZAEUS-MERZBACHER DISEASE
APP-BINDING
SURFACE
FLRT3
CELL
OUTGROWTH
ADHESION
NEURONS
SYSTEM
FE65
s disease
Spatial learning and memory impairments are associated with increased neuronal activity in 5XFAD mouse as measured by manganese-enhanced magnetic resonance imaging
期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 36, 页码: 57556
作者:
Nie, BB
;
Gu, LH
;
Wu, D
;
Tang, X
;
Nie BB(聂彬彬)
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2017/07/25
Alzheimer's disease
5XFAD mice
cognition
neuroimaging
manganese enhanced MRI
Pathology Section
Lost region in amyloid precursor protein (APP) through TALEN-mediated genome editing alters mitochondrial morphology
期刊论文
SCIENTIFIC REPORTS, 2016, 卷号: 6
作者:
Wang, Yajie
;
Wu, Fengyi
;
Pan, Haining
;
Zheng, Wenzhong
;
Feng, Chi
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/05
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